Thiry wistar rats were used and divided in 2 groups. A segment of 6mm was excised in the sciatic nerve which were then bridged with chitin and skelal muscle. at 4,8,12 weeks after operation, In the chitin group a satisfactory regeneration of nerve fibers was evident with electrophysiologic and histologic examinations, and HRP retrogade labelling evaluation. The possible mechanism of enhancing nerve regeneration of chitin was also discussed.