ObjectiveTo investigate relationship between nod-like-receptor protein 3 (NLRP3) inflammasome and acute pancreatitis induced pancreas and extrapancreatic organs injury.MethodThe related literatures on the relationship between the nod-like-receptor protein 1 inflammasome (NLRP3 inflammasome) and the acute pancreatitis in recent years were reviewed.ResultsThe activation and regulation of NLRP3 inflammatory corpuscle are involved in the injury of various organs in acute pancreatitis. The more the activation of NLRP3 inflammatory corpuscle, the more severe the damage to the body. Through the regulation of the activation mechanism of NLRP3 inflammatory corpuscle, the activation of NLRP3 inflammatory corpuscle can be reduced, and finally the injury of various organs can be reduced.ConclusionThe activation of NLRP3 inflammatory corpuscle is involved in the process of acute pancreatitis, but it still needs to be verified by further clinical studies.