Popularizing health knowledge scientifically and improving people’s health literacy level is one of the most economical and effective measures to improve people’s health level. In carrying out health science popularization work, public hospitals, as the main force of popular science, have some problems, such as lack of enthusiasm of medical staff, unfamiliarity with new means and laws of communication, too professional output and poor popularization effect. In recent years, West China Hospital of Sichuan University has taken the “West China Hospital Popular Medicine Readings” as the popular science brand, and through creating management mode, innovative creation mode, strengthening continuous training and system construction, it has formed a health science brand and explored a set of reproducible long-term mechanism for health science popularization. This article deeply analyzes the problems faced by public hospitals in developing health science popularization work, taking the work mode and achievements of West China Hospital as an example, and explores a new way for other public hospitals, especially small and medium-sized public hospitals, to develop health science popularization work.