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find Keyword "c-myc protein expression" 1 results
  • The Effects of Somatostatin Analog on the Apoptosis and the Expression of cmyc Protein of Hepatocellular Carcinoma Cell

    ObjectiveTo investigate the effects of somatostatin8 (SS8) on the apoptosis and the expression of cmyc protein of hepatocellular carcinoma cell SMMC7721. MethodsCultured in vitro, hepatocellular carcinoma cells SMMC7721 were incubated with SS8 (10 μg/ml). The apoptosis rate and expression of cmyc protein were detected by flow cytometry (FCM). ResultsSS8 can cause the spanonumber in S and G2/M phase and the auxonumber in G0/G1 phase of SMMC7721 cells . The apoptosis rate was 14.2% in the study group and 6.1% in the control group, and there was significant difference (P<0.05); The level of expressions of cmyc protein was 0.833±0.035 after action by SS8 for 24 h. Compared with control group, there was no significant difference in the study group(P>0.10).But after the cells were incubated with SS8 for 48,72,96,120,144 h, the level of expressions of cmyc protein was 0.818±0.04,0.721±0.029,0.669±0.026,0.648±0.045,0.642±0.028 respectively in the study group, and there was significant difference as compared with the control group (P<0.05). Conclusion The SS8 can induce the apoptosis and lower expression of cmyc protein of hepatocellular carcinoma cell SMMC7721.

    Release date:2016-08-28 04:47 Export PDF Favorites Scan
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