Medical engineering interdisciplinary aims to integrate medicine, engineering science and other disciplines and to carry out scientific research and application in a collaborative manner. At present, the demand for medical engineering interdisciplinary in the field of medical laboratory technology is increasing, which also puts forward new requirements for the “Clinical Microbiology Laboratory Technology”. This article elaborates on the necessity and existing problems of the medical engineering interdisciplinary, reports on the overall ideas of the curriculum reform of “Clinical Microbiology Laboratory Technology” at West China School of Medicine of Sichuan University based on the medical engineering interdisciplinary, and specifically elaborates on the reform practices in three aspects: teaching philosophy, teaching content and methods, and teacher optimization, as well as the preliminary achievements obtained, so as to provide new ideas for the curriculum reform of the “Clinical Microbiology Laboratory Technology”.