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find Keyword "cyclin E protein" 1 results
  • Expression and Significance of Cyclin E and p27kip1 in Gallbladder Carcinoma

    Objective To evaluate the expression of cyclin E and p27kip1 protein and their significance in gallbladder carcinoma. Methods SP immunohistochemistry was used to detect the expression of cyclin E and p27kip1 protein in 41 cases gallbladder carcinomas,15 cases chronic cholecystitis tissues. Results The positive rate of cyclin E in gallbladder carcinoma was 61.0%(25/41),which was significantly higher than that in chronic cholecystitis (20.0%,3/15),P<0.05; The expression of cyclin E positively correlated with tumor TNM staging (r=0.314,P<0.05). The positive rate of p27kip1 in gallbladder carcinoma was 53.7%(22/41),which was lower than that in chronic cholecystitis (100%). The positive rate of p27kip1 was decreased with the poor differentiation and progression of TNM staging. There was negative correlation between cyclin E and p27kip1 expression (r=-0.342,P<0.05). Conclusion The high expression of cyclin E and the decreased expression of p27kip1 result in abnomal regulation of cell cycle,which may be associated with gallbladder carcinogenesis and progression.

    Release date:2016-08-28 04:43 Export PDF Favorites Scan
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