Objective To understand the impact of an infection risk control measures implemented in the non-clinical areas of a hospital on the visitors during the coronavirus disease 2019 (COVID-19) epidemic period, in an attempt to provide scientific evidence for the improvement and optimization of subsequent prevention and control measures. Methods The convenience sampling method was used to investigate and analyze all the personnel who came to the hospital for treatment or work on February 22, 2020. Collect the influence of the personnel coming to the hospital on the sense of security, medical behavior (work) and the acceptance of the measures arising from the implementation of infection control measures such as sub-regional management of people and vehicles, body temperature screening during admission, and sub-channel management of hospital visitors in the non-clinical areas of the hospital. ResultsA total of 1 098 patients/family members were included. 70.13% (770/1 098) of the patients/family members thought that visiting the hospital during the COVID-19 epidemic would make them feel uneasy; 90.26% (991/1 098) of the patients/family members could accept the body temperature screening during admission, 96.99% (1 065 / 1 098) of the patients/family members could accept the sub-regional management of people and vehicles, and 100.00% (1 098/1 098) of the patients/family members could accept the sub-channel management of hospital visitors in the non-clinical areas of the hospital; 71.22% (782/1 098) of the patients/family members thought that the peripheral prevention and control measures had increased the sense of security in medical treatment, and they would continue to choose this hospital for the next time if necessary. A total of 2 543 employees were included. 37.55% (955/2543) of the employees felt uneasy because they were afraid of being infected in the hospital; 93.12% (2 368/2 543) of the employees could accept the establishment of a dedicated channel for staff admission, 99.25% (2 524/2 543) of the employees could accept the temperature screening at the entrance of the dedicated channel, and 97.48% (2 479/2 543) of the employees could accept the subregional management measures. 82.54% (2 099/2 543) of the employees thought that the peripheral prevention and control measures would not affect their work. Conclusions Implementing a series of prevention and control measures in the non-clinical areas during the emergency response state can improve the sense of security of the patients, family members of the patients and employees who come to the hospital to some extent. In the future, measures such as strengthening publicity and education, improving facilities, perfecting the planning and design, providing the complete information, and strengthening supervision, can be taken to further optimize the risk control of infection in non-clinical areas and improve the acceptance of personnel coming to the hospital.