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Interleukin10/interleukin6 and Nuclear FactorΚAppa B Activation in Acute Coronary Syndrome and Its Clinical Significance

摘要:目的：探讨急性冠脉综合征患者血清IL-10/IL-6平及NFκB活性变化。方法：采用ELISA法检测45例急性冠脉综合征（ACS）患者,20例稳定性心绞痛（SAP）患者,20例非冠心病为对照者血清IL-10、IL-6水平；同时细胞免疫组化测定各组外周血单个核细胞NF-κB活性。结果: ACS组血清IL-6/IL-10 比值及NF-κB活性均高于SAP组及对照组(ACS: 1.69 ±0.53,0.32± 0.12;SAP: 1.06 ± 0.38,0.13 ±0.07;对照组: 0.92 ± 0.41,0.11±0.09, 均P＜0.05)。结论：炎症介质及抗炎症介质分泌失衡在急性冠脉综合征中发挥了重要作用。Abstract: Objective: To evaluate the clinical value of Theratio IL6/IL10Interleukin10(IL10)/ interleukin6(IL6) and Nuclear factorκappa B activation in acute coronary syndrome. Methods: Serum level of IL10, IL6 were measured for 45 cases patients of acute coronary syndrome (ACS), 20 cases patients of stable angina pectoris (SAP) and 20 cases patients without Coronary heart diseas（CHD）as control group by means of Enzyme linked immune absorption assay, while NFκB Activation measured by cell immunohistochemical method In Peripheral blood monouclear cell. Results： The ratio IL6/IL10 and Nuclear factorκappa B activation were significantly higher in patients with ACS (169±053,032±012) than in those of SAP (106±038,013±007) and Control (092±041,011±009)(Plt;005). Conclusion：there was Inflammatory imbalance between IL10 and IL6 in ACS, Inflammatory effects is important to devope to acute coronary syndrome