Objective To analyze relevant literatures of three-dimensional (3D ) imaging in liver using bibiometric analysis, and to provide a current status and hotspot in this filed in future for liver surgeon. Methods The bibliographies of liver 3D imaging from November 2007 to November 2017 in the PubMed database were downloaded. The publication years, journals, the first authors, and the frequency of subject headings+subheadings were extracted by Bicomb 2.0 software. The subject headings+subheadings appeared more than 10 times were intercepted as high frequency ones, then created the high frequency subject headings+subheadings co-occurrence matrix. SPSS 22.0 software was applied for clustering analysis with this matrix to get the topic hotspot. Results A total of 269 literatures were screened out. The research in this field reached its peak in 2016. The core area of journals contained 12 journals. There were 6 authors published at least 3 relevant literatures. The number of high frequency subject headings+subheadings was 16. The research hotspot of liver 3D imaging was precise liver surgery. Conclusion Research hotspot of application of 3D imaging in liver is precise liver surgery in recent 10 years.