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find Keyword "retinal pigment epithelium" 1 results
  • CHARACTERIZATION OF SEROTONERGIC, 5-HT2 RECEPTORS IN CULTURED RAT RETINAL PIGMENT EPITHELIAL CELLS

    The effects of various receptor agonists/antagonists on the accumulation of inositol phosphates(InsPs) in cultured rat retinal pigment epitheium (RPE) cells were analysed. The results showed that serotonin and the 5-HT2 agonists such as alpha;-methyl-serotonin, quipazine, and DOI (1-[2.5-dimethoxy-4-iodopheny1]-2-aminopropane) all stimulated InsPs accumulation in rat RPE cells. The serotonin-induced stimulation of InsPs was effectively blocked by ketanserin, a 5-HT2 antagonist, but also attenuated by the active phorbol ester PMA (4ft-phorbol 12-myristate 13-acetate), a potent protein kinase C activator.The data presented provide clear evidence for the presence of 5-HT2 receptors coupled to phosphoinositide metabolism on cultured rat RPE cells. (Chin J Ocul Fundus Dis,1994,10:80-83)

    Release date:2016-09-02 06:34 Export PDF Favorites Scan
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