Objective To review the application and research progress of transcutaneous oxygen pressure (TcPO2) in scar assessment. Methods The original articles about scar and TcPO2 were reviewed and analyzed. Results Hypoxia environment plays an important role in the progression of scar tissue. TcPO2 can accurately reflect the oxygen tension of scar tissue, which is of great significance in the assessment of scar maturity, the guidance of scar treatment, and the study of correlations between hypoxia and the progression of scar. Conclusion TcPO2 measurement is important in the study of scar evaluation, treatment, and correlation between hypoxia and scar formation.