In order to satisfy demands of massive and heterogeneous tumor clinical data processing and the multi-center collaborative diagnosis and treatment for tumor diseases, a Tumor Data Interacted System (TDIS) was established based on grid platform, so that an implementing virtualization platform of tumor diagnosis service was realized, sharing tumor information in real time and carrying on standardized management. The system adopts Globus Toolkit 4.0 tools to build the open grid service framework and encapsulats data resources based on Web Services Resource Framework (WSRF). The system uses the middleware technology to provide unified access interface for heterogeneous data interaction, which could optimize interactive process with virtualized service to query and call tumor information resources flexibly. For massive amounts of heterogeneous tumor data, the federated stored and multiple authorized mode is selected as security services mechanism, real-time monitoring and balancing load. The system can cooperatively manage multi-center heterogeneous tumor data to realize the tumor patient data query, sharing and analysis, and compare and match resources in typical clinical database or clinical information database in other service node, thus it can assist doctors in consulting similar case and making up multidisciplinary treatment plan for tumors. Consequently, the system can improve efficiency of diagnosis and treatment for tumor, and promote the development of collaborative tumor diagnosis model.