Synchronous Double Primary Lung Cancer: One Case Report and Literature Review_Chinese Journal of Respiratory and Critical Care Medicine

Authors：

LiZhao ¹ , SongMin ² ,  JiangLuning ¹ , SuNa ²

1. Affiliated Hospital of Jining Medical University, Jining, Shandong, 272067, China;
2. ;

Corresponding author：

JiangLuning, Email: w13001786181@126.com

Keywords：

Bronchoscope; Double primary lung cancer; Squamous cell carcinoma; Small cell lung carcinoma

DOI：

10.7507/1671-6205.2016136

Video：

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Objective To improve the knowledge of double primary lung cancer. Methods A case of synchronous double primary lung cancers, who was diagnosed by bronchoscopic examination and immunohistochemical staining in our department in 2012, was analyzed retrospectively. The literatures were review with "double primary, lung cancer, squamous cell carcinoma, small cell lung carcinoma" as the research terms in Wanfang, CNKI and PubMed database. Results A 76-year-old male patient complained of intermittent cough, chest pain and wheezing over half a month. Chest computer tomography showed masslike lesion with high density in hilum of right lung. The patient received bronchoscopic examination, the pathological and immunohistochemical findings was squamous cell carcinoma and small cell lung carcinoma. The imaging manifestations and bronchoscopy findings were consistent with pathologic diagnosis. A total of 7 pieces of literature were retrived in above-mentioned databases. Seven patients had long smoke history and 6 were male. Four patients complained about couph and sputum, and 1 patient had chest pain. CT showed masses in the lung or hilus with or without stenosis and obliteration of the bronchus. Five patients were proven by bronchoscopy and biopsy. Conclusion Double primary lung cancer has characteristics in radiologic features and bronchoscopy performance, so can be early diagnosed by bronchoscopy and histopathology.

Citation： LiZhao, SongMin, JiangLuning, SuNa. Synchronous Double Primary Lung Cancer: One Case Report and Literature Review. Chinese Journal of Respiratory and Critical Care Medicine, 2016, 15(6): 597-602. doi: 10.7507/1671-6205.2016136 Copy

1.	Griffioen GH, Lagerwaard FJ, Haasbeek CJ, et al. Treatment of multiple primary lung cancers using stereotactic radiotherapy, either with or without surgery. Radiother Oncol, 2013, 107:403-408.
2.	Gazdar AF, Minnat JD. Multifocal lung cancers-clonality vs field cencerization and does it matter? J Natl Cancer Inst, 2009, 101:541-543.
3.	李月越, 吴继华, 王瑞娟, 等.肺小细胞癌混合肺鳞癌1例.临床肺科志, 2012, 17:1740.
4.	林晓, 林其昌, 黄东煜, 等.多原发性肺癌1例报告并文献复习.国际呼吸杂志, 2013, 33:157-159.
5.	Liu XD, Qu Y, Lu SS. Synchronous double primary lung cancer:a report of three cases. Chin J Cancer Res, 2014, 26:E17-E21.
6.	Gogakos AS, Paliouras D, Rallis T, et al. Double primary non-small cell lung cancer with synchronous small cell lung cancer N2 nodes:a case report. Ann Transl Med, 2015, 3:157.
7.	李乐, 张晨媛, 祖金池, 等.同时、同侧、异叶双原发肺癌1例.中华保健医学杂志, 2015, 17:57-58.
8.	刘冬梅, 李栋, 孙文逵, 等.同时性双原发肺癌1例.临床肿瘤学杂志, 2015, 20:572-574.
9.	吴波, 丁笑笑, 徐红燕, 等.双原发肺癌多发转移一例报告.新医学, 2016, 47:412-416.
10.	Dai L, Yang HL, Yan WP, et al. The equivalent efficacy of multiple operations for multiple primary lung cancer and a single operation for single primary lung cancer. J Thorac Dis, 2016, 8:855-861.
11.	Takao M, Watanabe F, Shimamoto A, et al. Analyses of multiple primary lung cancers recent trend. Kyobu Geka, 2002, 55:15-19.
12.	王国凤, 来茂德, 陈培辉.多原发性肺癌与支气管肺泡上皮异型增生关系的研究.浙江大学学报(医学版), 2005, 34:427-431.
13.	Tanvetyanon T, Finley DJ, Fabian T, et al. Prognostic factors for survival after complete resections of synchronous lung cancers in multiple lobes:pooled analysis based on individual patient data. Ann Oncol, 2013, 24:889-894.
14.	蒋丹, 徐香玖, 黄刚.中央型肺小细胞癌和鳞癌的鉴别诊断:MSCT征象对照及其回归分析.实用放射学杂志, 2008, 24:173-175.
15.	张高峰, 先正元, 陈华.40例小细胞肺癌的螺旋CT表现.医学影像学杂志, 2008, 18:603-605.
16.	Travis WD. Update on small cell carcinoma and its differentiation from squamous cell carcinoma and other non-small cell carcinomas. Mod Pathol, 2012, 25:S18-S30.
17.	陈克终, 王迅, 杨帆, 等.不同影像学表现的多原发肺癌的临床特点及诊疗效果分析.中华外科杂志, 2015, 53:731-736.
18.	Nicholson SA, Beasley MB, Brambilla E, et al. Small cell lung carcinoma (SCLC):a clinicopathologic study of 100 cases with surgical specimens. Am J Surg Pathol, 2002, 26:1184-1197.
19.	McElvaney G, Miller RR, Muller NL, et al. Multicentricity of adenocarcinoma of the lung. Chest, 1989, 95:151-154.
20.	李红方, 梁冰锋, 王辰生, 等.肺小细胞癌和鳞状细胞癌患者ASHl及独立生长因子-1的表达与预后的相关性.中华结核和呼吸杂志, 2012, 35:534-536.
21.	李丽华, 史健.肿瘤微环境与肺癌相关性研究进展.中国肿瘤杂志, 2015, 24:501-504.
22.	Ishikawa Y, Nakayama H, Ito H, et al. Surgical treatment for synchronous primary lung adenocarcinomas. Ann Thorac Surg, 2014, 98:1983-1988.
23.	Ye C, Wang J, Li W, et al. Novel strategy for synchronous multiple primary lung cancer displaying unique molecular profiles. Ann Thorac Surg, 2016, 101:e45-47.
24.	Takahashi E, Koshiishi H, Sakaniwa N, et al. Photodynamic therapy for multiple central type lung cancer--a case report. Gan to Kagaku Ryoho, 2014, 41:2042-2043.
25.	Simone CB 2nd, Cengel KA. Photodynamic therapy for lung cancer and malignant pleural mesothelioma. Semin Oncol, 2014, 41:820-830.

1. Griffioen GH, Lagerwaard FJ, Haasbeek CJ, et al. Treatment of multiple primary lung cancers using stereotactic radiotherapy, either with or without surgery. Radiother Oncol, 2013, 107:403-408.
2. Gazdar AF, Minnat JD. Multifocal lung cancers-clonality vs field cencerization and does it matter? J Natl Cancer Inst, 2009, 101:541-543.
3. 李月越, 吴继华, 王瑞娟, 等.肺小细胞癌混合肺鳞癌1例.临床肺科志, 2012, 17:1740.
4. 林晓, 林其昌, 黄东煜, 等.多原发性肺癌1例报告并文献复习.国际呼吸杂志, 2013, 33:157-159.
5. Liu XD, Qu Y, Lu SS. Synchronous double primary lung cancer:a report of three cases. Chin J Cancer Res, 2014, 26:E17-E21.
6. Gogakos AS, Paliouras D, Rallis T, et al. Double primary non-small cell lung cancer with synchronous small cell lung cancer N2 nodes:a case report. Ann Transl Med, 2015, 3:157.
7. 李乐, 张晨媛, 祖金池, 等.同时、同侧、异叶双原发肺癌1例.中华保健医学杂志, 2015, 17:57-58.
8. 刘冬梅, 李栋, 孙文逵, 等.同时性双原发肺癌1例.临床肿瘤学杂志, 2015, 20:572-574.
9. 吴波, 丁笑笑, 徐红燕, 等.双原发肺癌多发转移一例报告.新医学, 2016, 47:412-416.
10. Dai L, Yang HL, Yan WP, et al. The equivalent efficacy of multiple operations for multiple primary lung cancer and a single operation for single primary lung cancer. J Thorac Dis, 2016, 8:855-861.
11. Takao M, Watanabe F, Shimamoto A, et al. Analyses of multiple primary lung cancers recent trend. Kyobu Geka, 2002, 55:15-19.
12. 王国凤, 来茂德, 陈培辉.多原发性肺癌与支气管肺泡上皮异型增生关系的研究.浙江大学学报(医学版), 2005, 34:427-431.
13. Tanvetyanon T, Finley DJ, Fabian T, et al. Prognostic factors for survival after complete resections of synchronous lung cancers in multiple lobes:pooled analysis based on individual patient data. Ann Oncol, 2013, 24:889-894.
14. 蒋丹, 徐香玖, 黄刚.中央型肺小细胞癌和鳞癌的鉴别诊断:MSCT征象对照及其回归分析.实用放射学杂志, 2008, 24:173-175.
15. 张高峰, 先正元, 陈华.40例小细胞肺癌的螺旋CT表现.医学影像学杂志, 2008, 18:603-605.
16. Travis WD. Update on small cell carcinoma and its differentiation from squamous cell carcinoma and other non-small cell carcinomas. Mod Pathol, 2012, 25:S18-S30.
17. 陈克终, 王迅, 杨帆, 等.不同影像学表现的多原发肺癌的临床特点及诊疗效果分析.中华外科杂志, 2015, 53:731-736.
18. Nicholson SA, Beasley MB, Brambilla E, et al. Small cell lung carcinoma (SCLC):a clinicopathologic study of 100 cases with surgical specimens. Am J Surg Pathol, 2002, 26:1184-1197.
19. McElvaney G, Miller RR, Muller NL, et al. Multicentricity of adenocarcinoma of the lung. Chest, 1989, 95:151-154.
20. 李红方, 梁冰锋, 王辰生, 等.肺小细胞癌和鳞状细胞癌患者ASHl及独立生长因子-1的表达与预后的相关性.中华结核和呼吸杂志, 2012, 35:534-536.
21. 李丽华, 史健.肿瘤微环境与肺癌相关性研究进展.中国肿瘤杂志, 2015, 24:501-504.
22. Ishikawa Y, Nakayama H, Ito H, et al. Surgical treatment for synchronous primary lung adenocarcinomas. Ann Thorac Surg, 2014, 98:1983-1988.
23. Ye C, Wang J, Li W, et al. Novel strategy for synchronous multiple primary lung cancer displaying unique molecular profiles. Ann Thorac Surg, 2016, 101:e45-47.
24. Takahashi E, Koshiishi H, Sakaniwa N, et al. Photodynamic therapy for multiple central type lung cancer--a case report. Gan to Kagaku Ryoho, 2014, 41:2042-2043.
25. Simone CB 2nd, Cengel KA. Photodynamic therapy for lung cancer and malignant pleural mesothelioma. Semin Oncol, 2014, 41:820-830.

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