The macular vascular density and the area of foveal avascular zone in the follow eyes of monocular retinal vein occlusion patients_Chinese Journal of Ocular Fundus Diseases

Authors：

Fu Bibo ^1,2 , Chen Xiaoling ^1,2 ,  Ye Bo ³ , Huang Yinhua ³

1. Aier School of Ophthalmoloy, Central South University, Changsha 410015, China;
2. Changsha Aier Eye Hospital, Changsha 410015, China;
3. Nanchang Aier Eye Hospital, Nanchang 330026, China;

Corresponding author：

Ye Bo, Email: yebo814@126.com

Keywords：

Retinal vein occlusion; Regional blood flow; Tomographyoptical coherence

DOI：

10.3760/cma.j.cn511434-20190103-00004

Video：

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Objective To observe the macular vascular density and the area of foveal avascular zone (FAZ) in the follow eyes of monocular retinal vein occlusion (RVO) patients.Methods Retrospective case-control study. From May to November 2018, 78 follow eyes of 78 monocular RVO patients who were clinically diagnosed in Changsha Aier Eye Hospital were included in the study. Among them, 44 were male and 34 were female. The average age was 53.17±10.12 years. There were 42 patients with central retinal vein occlusion (CRVO group) and 36 patients with branch retinal vein occlusion (BRVO group). Forty-two eyes of 33 gender and age matched healthy volunteers were selected as the control group. Among them, 17 were male (22 eyes) and 16 were female (20 eyes), with the mean age of 53.48±10.84 years. OCT angiography was performed on all eyes in CRVO group, BRVO group and control group. The scanning region in the macular area was 6 mm×6 mm. Macular vascular density and FAZ area in the superficial and deep retinal capillary plexi were measured.Results The mean overall vascular density measured in the entire scan was lower in the CRVO group (t=－4.26, －4.93) and BRVO group (t=－4.79, －4.74) compared with the control group in both the superficial and deep capillary plexus (P＜0.05). The reduce degree of vascular density in the deep capillary plexus (CRVO group:5.51%, BRVO group:4.58%) was higher than that in the superficial plexus (CRVO group:4.13%, BRVO group:3.50%). In the CRVO group, the FAZ area decreased compared with the control group (t=－3.43, P＜0.05). There was no statistically significant difference in the area of FAZ between the BRVO group and the control group (t=－0.10, P＞0.05).Conclusions The macular vascular density in the follow eyes of monocular RVO patients is lower than that of normal healthy eyes. The reduce degree of vascular density in the deep capillary plexus is higher than that in the superficial plexus. Compared with normal healthy eyes, the FAZ area in the follow eyes of monocular CRVO patients decreased, while it did not change significantly in the follow eyes of monocular BRVO patients.

Citation： Fu Bibo, Chen Xiaoling, Ye Bo, Huang Yinhua. The macular vascular density and the area of foveal avascular zone in the follow eyes of monocular retinal vein occlusion patients. Chinese Journal of Ocular Fundus Diseases, 2020, 36(4): 285-288. doi: 10.3760/cma.j.cn511434-20190103-00004 Copy

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14.	Tsai G, Banaee T, Conti FF, et al. Optical coherence tomography angiography in eyes with retinal vein occlusion[J]. J Ophthalmic Vis Res, 2018, 13(3): 315-332. DOI: 10.4103/jovr.jovr_264_17.
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18.	Tan CS, Lim LW, Chow VS, et al. Optical coherence tomography angiography evaluation of the parafoveal vasculature and its relationship with ocular factors[J]. Invest Ophthalmol Vis Sci, 2016, 57(9): 224-234. DOI: 10.1167/iovs.15-18869.
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1. Kim MJ, Woo SJ, Park KH, et al. Retinal nerve fiber layer thickness is decreased in the fellow eyes of patients with unilateral retinal vein occlusion[J]. Ophthalmology, 2011, 118(4): 706-710. DOI: 10.1016/j.ophtha.2010.08.028.
2. Sakaue H, Katsumi O, Hirose T. Electroretinographic findings in fellow eyes of patients with central retinal vein occlusion[J]. Arch Ophthalmol, 1989, 107(10): 1459-1462. DOI: 10.1001/archopht.1989.01070020533033.
3. Jonas JB, Nangia V, Khare A, et al. Prevalence and associations of retinal vein occlusions: the Central India Eye and Medical Study[J]. Retina, 2013, 33(1): 152-159. DOI: 10.1097/IAE.0b013e318260246f.
4. Kashani AH, Chen CL, Gahm JK, et al. Optical coherence tomography angiography: a comprehensive review of current methods and clinical applications[J]. Prog Retin Eye Res, 2017, 60: 66-100. DOI: 10.1016/j.preteyeres.2017.07.002.
5. Adhi M, Filho MA, Louzada RN, et al. Retinal capillary network and foveal avascular zone in eyes with vein occlusion and fellow eyes analyzed with optical coherence tomography angiography[J]. Invest Ophthalmol Vis Sci, 2016, 57(9): 486-494. DOI: 10.1167/iovs.15-18907.
6. 李可嘉, 喻晓兵, 陈沁. 视网膜分支静脉阻塞患眼黄斑区血流密度及黄斑中心凹无血管区面积测量结果观察[J]. 中华眼底病杂志, 2018, 34(1): 17-20. DOI: 10.3760/cma.j.issn.1005-1015.2018.01.005.Li KJ, Yu XB, Chen Q. Observation of blood flow density in macular area and area of avascular area of macular fovea in patients with branch retinal vein occlusion[J]. Chin J Ocul Fundus Dis, 2018, 34(1): 17-20. DOI: 10.3760/cma.j.issn.1005-1015.2018.01.005.
7. 卢宁, 张承芬. 视网膜静脉阻塞[M]//张承芬. 眼底病学. 2版.北京: 人民卫生出版社, 2010: 237-243.Lu N, Zhang CF. Retinal vein occlusion[M]//Zhang CF. Diseases of ocular fundus. 2nd ed. Beijing: People's Medical Publishing House, 2010: 237-243.
8. Ip M, Hendrick A. Retinal vein occlusion review[J]. Asia Pac J Ophthalmol (Phila), 2018, 7(1): 40-45. DOI: 10.22608/APO.2017442.
9. MacDonald D. The ABCs of RVO: a review of retinal venous occlusion[J]. Clin Exp Optom, 2014, 97(4): 311-323. DOI: 10.1111/cxo.12120.
10. McIntosh RL, Rogers SL, Lim L, et al. Natural history of central retinal vein occlusion: an evidence-based systematic review[J]. Ophthalmology, 2010, 117(6): 1113-1123. DOI: 10.1016/j.ophtha.2010.01.060.
11. Lin CP, Lin FY, Huang PH, et al. Endothelial progenitor cell dysfunction in cardiovascular diseases: role of reactive oxygen species and inflammation[J/OL]. Biomed Res Int, 2013, 2013: 845037[2012-12-30]. https://doi.org/10.1155/2013/845037. DOI: 10.1155/2013/845037.
12. Mittal M, Siddiqui MR, Tran K, et al. Reactive oxygen species in inflammation and tissue injury[J]. Antioxid Redox Signal, 2014, 20(7): 1126-1167. DOI: 10.1089/ars.2012.5149.
13. Virdis A, Dell'Agnello U, Taddei S. Impact of inflammation on vascular disease in hypertension[J]. Maturitas, 2014, 78(3): 179-183. DOI: 10.1016/j.maturitas.2014.04.012.
14. Tsai G, Banaee T, Conti FF, et al. Optical coherence tomography angiography in eyes with retinal vein occlusion[J]. J Ophthalmic Vis Res, 2018, 13(3): 315-332. DOI: 10.4103/jovr.jovr_264_17.
15. de Carlo TE, Romano A, Waheed NK, et al. A review of optical coherence tomography angiography (OCTA)[J/OL]. Int J Retina Vitreous, 2015, 1: 5[2015-04-15]. https://journalretinavitreous.biomedcentral.com/articles/10.1186/s40942-015-0005-8. DOI:10.1186/s40942-015-0005-8.
16. Coscas F, Glacet-Bernard A, Miere A, et al. Optical coherence tomography angiography in retinal vein occlusion: evaluation of superficial and deep capillary plexa[J]. Am J Ophthalmol, 2016, 161: 160-171. DOI: 10.1016/j.ajo.2015.10.008.
17. Parodi MB, Visintin F, Della Rupe P, et al. Foveal avascular zone in macular branch retinal vein occlusion[J]. Int Ophthalmol, 1995, 19(1): 25-28. DOI: 10.1007/BF00156415.
18. Tan CS, Lim LW, Chow VS, et al. Optical coherence tomography angiography evaluation of the parafoveal vasculature and its relationship with ocular factors[J]. Invest Ophthalmol Vis Sci, 2016, 57(9): 224-234. DOI: 10.1167/iovs.15-18869.
19. Wons J, Pfau M, Wirth MA, et al. Optical coherence tomography angiography of the foveal avascular zone in retinal vein occlusion[J]. Ophthalmologica, 2016, 235(4): 195-202. DOI: 10.1159/000445482.

Chinese Journal of Ocular Fundus Diseases

The macular vascular density and the area of foveal avascular zone in the follow eyes of monocular retinal vein occlusion patients

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