Expression and significance of SOX11 in retinoblastoma_Chinese Journal of Ocular Fundus Diseases

Authors：

 Song Haogang ¹ , Wang Le ¹ , Zhao Jun ²

1. Putian Eye Hospital of Huaxia Eye Hospital Group, Putian 351100, China;
2. Department of Dermatology, Heilongjiang Provincial Hospital, Harbin 150001, China;

Corresponding author：

Song Haogang, Email: songhaogang@outlook.com

Keywords：

Retinoblastoma/etiology; SOXC transcription factors; Genes

DOI：

10.3760/cma.j.cn511434-20190509-00175

Video：

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Objective To investigate the expression of transcription factor SOX11 in retinoblastoma (RB) and the relation with the genes and cellular pathways.Methods A public data set gse59983 containing the full mRNA expression profile of cancer tissues in 76 RB patients was downloaded from the GEO Database at the National Center for Biotechnology Information. According to the expression of 15 marker genes, these genes were divided into cell cycle marker genome (group 1, 26 patients), vertebral photoreceptor marker genome (group 2, 4 patients) and rod photoreceptor marker gene (group 3, 46 patients). R2 bioinformatics platform (http://r2.amc.NL) was used to analyze the gse59983 public data set. The SOX11 expression in cancer tissues of patients in 3 groups were observed and the SOX11-related genes were identified. According to the gene correlation, the clustering heat map was drawn, and the related genes and pathways of SOX11 were preliminarily analyzed by Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis tool and Gene Annotation (GO) analysis method.Results SOX11 expression in cancer tissues of patients in group 1 was significantly higher than that of groups 2 and 3 (P＜0.001). SOX11 expression in cancer tissues of patients in group 3 was significantly higher than that in group 2 (P＜0.001). A total of 4524 genes significantly related to SOX11 expression were detected. Among them, there were 2139 positively correlated genes and 2385 negatively correlated genes. SOX11 and the 16 genes with the strongest correlation were screened and the clustering heat map was drawn. The clustering form of SOX11 and SOX11 significantly correlated genes was roughly the same as the original form. KEGG and GO analysis showed that SOX11 related genes were involved in regulating mitotic cell cycle, cell apoptosis, photoreceptor cell development, photoreceptor cell protection, etc.Conclusion The expression of SOX11 in RB is significantly different in different types or periods. Its expression is significantly correlated with genes involved in the regulation of cell cycle.

Citation： Song Haogang, Wang Le, Zhao Jun. Expression and significance of SOX11 in retinoblastoma. Chinese Journal of Ocular Fundus Diseases, 2020, 36(6): 430-434. doi: 10.3760/cma.j.cn511434-20190509-00175 Copy

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8.	Liu Z, Zhong Y, Chen YJ, et al. SOX11 regulates apoptosis and cell cycle in hepatocellular carcinoma via Wnt/β-catenin signaling pathway[J]. Biotechnol Appl Biochem, 2019, 66(2): 240-246. DOI: 10.1002/bab.1718.
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10.	Xu XY, Chang XJ, Li ZH, et al. Aberrant SOX11 promoter methylation is associated with poor prognosis in gastric cancer[J]. Cell Oncol (Dordr), 2015, 38(3): 183-194. DOI: 10.1007/s13402-015-0219-7.
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1. Guo L, Bai Y, Ji SZ, et al. MicroRNA-98 suppresses cell growth and invasion of retinoblastoma via targeting the IGF1R/k-Ras/Raf/MEK/ERK signaling pathway[J]. Int J Oncol, 2019, 54(3): 807-820. DOI: 10.3892/ijo.2019.4689.
2. Kooi IE, Mol BM, Moll AC, et al. Loss of photoreceptorness and gain of genomic alterations in retinoblastoma reveal tumor progression[J]. EBioMedicine, 2015, 2(7): 660-670. DOI: 10.1016/j.ebiom.2015.06.022.
3. McEvoy J, Flores-Otero J, Zhang JK, et al. Coexpression of normally incompatible developmental pathways in retinoblastoma genesis[J]. Cancer Cell, 2011, 20(2): 260-275. DOI: 10.1016/j.ccr.2011.07.005.
4. Kapatai G, Brundler MA, Jenkinson H, et al. Gene expression profiling identifies different sub-types of retinoblastoma[J]. Br J Cancer, 2013, 109(2): 512-525. DOI: 10.1038/bjc.2013.283.
5. Mohammad G, AlSharif HM, Siddiquei MM, et al. Rho-associated protein kinase-1 mediates the regulation of inflammatory markers in diabetic retina and in retinal müller cells[J]. Ann Clin Lab Sci, 2018, 48(2): 137-145.
6. Yang WJ, Wang YY, Yu Z, et al. SOX11 regulates the pro-apoptosis signal pathway and predicts a favorable prognosis of mantle cell lymphoma[J]. Int J Hematol, 2017, 106(2): 212-220. DOI: 10.1007/s12185-017-2236-y.
7. Teng Y, Fan YC, Mu NN, et al. Serum SOX11 promoter methylation is a novel biomarker for the diagnosis of Hepatitis B virus-related hepatocellular carcinoma[J]. Neoplasma, 2016, 63(3): 419-426. DOI: 10.4149/311_151029N552.
8. Liu Z, Zhong Y, Chen YJ, et al. SOX11 regulates apoptosis and cell cycle in hepatocellular carcinoma via Wnt/β-catenin signaling pathway[J]. Biotechnol Appl Biochem, 2019, 66(2): 240-246. DOI: 10.1002/bab.1718.
9. Zhang S, Li S, Gao JL. Promoter methylation status of the tumor suppressor gene SOX11 is associated with cell growth and invasion in nasopharyngeal carcinoma[J]. Cancer Cell Int, 2013, 13(1): 109. DOI: 10.1186/1475-2867-13-109.
10. Xu XY, Chang XJ, Li ZH, et al. Aberrant SOX11 promoter methylation is associated with poor prognosis in gastric cancer[J]. Cell Oncol (Dordr), 2015, 38(3): 183-194. DOI: 10.1007/s13402-015-0219-7.
11. Goyal B, Duncavage EJ, Martinez D, et al. Next-generation sequencing of salivary high-grade neuroendocrine carcinomas identifies alterations in RB1 and the mTOR pathway[J]. Exp Mol Pathol, 2014, 97(3): 572-578. DOI: 10.1016/j.yexmp.2014.10.011.

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