Current situation and progress of microperimeter biofeedback training and its application in macular diseases_Chinese Journal of Ocular Fundus Diseases

Authors：

Liang Dongqing , Liu Yuyan ,  Han Quanhong

Tianjin Eye Hospital, Tianjin Key Laboratory of Ophthalmology and Visual Science, Tianjin Eye Institute, Tianjin 300000, China;
Liang Dongqing, is working at East Ophthalmology Department of Suzhou Municipal Hospital, Suzhou 215000, China;

Corresponding author：

Han Quanhong, Email: Hanquanhong126@126.com

Keywords：

Visual fields; Feedback, physiological; Review

DOI：

10.3760/cma.j.cn511434-20190521-00180

Video：

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When macular diseases involves the fovea, patients' central vision is significantly reduced. A central dark spot appears in the visual field, and their visual function indicators, such as reading speed and fixation stability, are significantly impaired, which seriously affects the patients' quality of life. The human body's response to the damage of the fovea region is a spontaneous adaptation strategy adopted by the brain. The brain will select the paracentral region as the pseudo fovea to serve as the fixation site of the eye, however, the development of patient's own residual vision is not maximized by this adaptation behavior. In recent years, through continuous research, it has been discovered that the automatic eye position recognition and automatic eye tracking system in the microperimeter can accurately detect specific retinal sites, combined with the biofeedback training mode, and can combine fundus examination with biofeedback training. It can help patients with age-related macular degeneration, pathological myopia macular degeneration, Stargardt's disease, macular hole and other macular diseases to choose the best retinal site as an eye movement benchmark, maximize the patient's residual vision and improve the patient's visual function.

Citation： Liang Dongqing, Liu Yuyan, Han Quanhong. Current situation and progress of microperimeter biofeedback training and its application in macular diseases. Chinese Journal of Ocular Fundus Diseases, 2020, 36(10): 817-820. doi: 10.3760/cma.j.cn511434-20190521-00180 Copy

1.	Mitchell P, Liew G, Gopinath B, et al. Age-related macular degeneration[J]. Lancet, 2018, 392(10153): 1147-1159. DOI: 10.1016/S0140-6736(18)31550-2.
2.	Kumar A, Chawla R, Kumawat D, et al. Insight into high myopia and the macula[J]. Indian J Ophthalmol, 2017, 65(2): 85-91. DOI: 10.4103/ijo.IJO_863_16.
3.	Tsang SH, Sharma T. Stargardt disease[J]. Adv Exp Med Biol, 2018, 1085: 139-151. DOI: 10.1007/978-3-319-95046-4_27.
4.	Samoylov AN, Khaibrakhmanov TR, Fazleeva GA, et al. Idiopathic macular hole: history and status quo review[J]. Vestn Oftalmol, 2017, 133(6): 131-137. DOI: 10.17116/oftalma20171336131-137.
5.	Vingolo EM, Napolitano G, Fragiotta S. Microperimetric biofeedback training: fundamentals, strategies and perspectives[J]. Front Biosci (Schol Ed), 2018, 10: 48-64. DOI: 10.2741/s500.
6.	Dario G, Contestabile MT, Pacella E, et al. An instrument for biofeedback applied to vision[J]. Appl Psychophysiol Biofeedback, 2005, 30(4): 389-395. DOI: 10.1007/s10484-005-8424-1.
7.	Cassels NK, John MW, Margrain TH, et al. The use of microperimetry in assessing visual function in age-related macular degeneration[J]. Surv Ophthalmol, 2018, 63(1): 40-55. DOI: 10.1016/j.survophthal.2017.05.007.
8.	Wang JW, Jie CH, Tao YJ, et al. Macular integrity assessment to determine the association between macular microstructure and functional parameters in diabetic macular edema[J]. Int J Ophthalmol, 2018, 11(7): 1185-1191. DOI: 10.18240/ijo.2018.07.18.
9.	Cheung SH, Legge GE. Functional and cortical adaptations to central vision loss[J]. Visual Neuroscience, 2005, 22(2): 187-201. DOI: 10.1017/S0952523805222071.
10.	Morales MU, Saker S, Mehta RL, et al. Preferred retinal locus profile during prolonged fixation attempts[J]. Can J Ophthalmol, 2013, 48(5): 368-374. DOI: 10.1016/j.jcjo.2013.05.022.
11.	Markowitz SN, Sophia VR. Microperimetry and clinical practice: an evidence-based review[J]. Can J Ophthalmol, 2013, 48(5): 350-357. DOI: 10.1016/j.jcjo.2012.03.004.
12.	Tarita-Nistor L, González EG, Markowitz SN, et al. Plasticity of fixation in patients with central vision loss[J]. Vis Neurosci, 2009, 26(5-6): 487-494. DOI: 10.1017/S0952523809990265.
13.	Chiang WY, Lee JJ, Chen YH, et al. Fixation behavior in macular dystrophy assessed by microperimetry[J]. Graefe’s Arch Clin Exp Ophthalmol, 2018, 256(8): 1403-1410. DOI: 10.1007/s00417-018-4006-9.
14.	Mandelcorn MS, Podbielski DW, Mandelcorn ED. Fixation stability as a goal in the treatment of macular disease[J]. Can J Ophthalmol, 2013, 48(5): 364-367. DOI: 10.1016/j.jcjo.2013.05.006.
15.	Molina-Martín A, Pérez-Cambrodí RJ, Piñero DP. Current clinical application of microperimetry: a review[J]. Semin Ophthalmol, 2018, 33(5): 620-628. DOI: 10.1080/08820538.2017.1375125.
16.	Timberlake GT, Sharma MK, Grose SA, et al. Retinal location of the preferred retinal locus relative to the fovea in scanning laser ophthalmoscope images[J]. Optom Vis Sci, 2005, 82(3): 177-185. DOI: 10.1097/01.opx.0000156311.49058.c8.
17.	Wong EN, Mackey DA, Morgan WH, et al. Inter-device comparison of retinal sensitivity measurements: the CenterVue MAIA and the Nidek MP-1[J]. Clin Exp Ophthalmol, 2016, 44(1): 15-23. DOI: 10.1111/ceo.12629.
18.	Hernández-Zimbrón LF, Zamora-Alvarado R, Ochoa-De La Paz L, et al. Age-related macular degeneration: new paradigms for treatment and management of AMD[J/OL]. Oxid Med Cell Longev, 2018, 2018: 8374647[2018-02-01]. https://pubmed.ncbi.nlm.nih.gov/29484106/. DOI: 10.1155/2018/8374647.
19.	Hanout M, Horan N, Do DV. Introduction to microperimetry and its use in analysis of geographic atrophy in age-related macular degeneration[J]. Curr Opin Ophthalmol, 2015, 26(3): 149-156. DOI: 10.1097/ICU.0000000000000153.
20.	Vingolo EM, Cavarretta S, Domanico D, et al. Microperimetric biofeedback in AMD patients[J]. Appl Psychophysiol Biofeedback, 2007, 32(3): 185-189. DOI: 10.1007/s10484-007-9038-6.
21.	Barboni MTS, Récsán Z, Szepessy Z, et al. Preliminary findings on the optimization of visual performance in patients with age-related macular degeneration using biofeedback training[J]. Appl Psychophysiol Biofeedback, 2019, 44(1): 61-70. DOI: 10.1007/s10484-018-9423-3.
22.	Ramírez Estudillo JA, León Higuera MI, Rojas Juárez S, et al. Visual rehabilitation via microperimetry in patients with geographic atrophy: a pilot study[J/OL]. Int J Retina Vitreous, 2017, 3: 21[2017-05-22]. https://pubmed.ncbi.nlm.nih.gov/28536656/. DOI: 10.1186/s40942-017-0071-1.
23.	李娟娟, 张书林, 黎铧, 等. Stargardt病不同阶段荧光素眼底血管造影的临床观察[J]. 中华实验眼科杂志, 2013, 31(1): 17-18. DOI: 10.3760/cma.j.issn.2095-0160.2013.01.004.Li JJ, Zhang SL, Li H, et al. Clinical observation of fundus fluorescein angiography in different stages of Stargardt disease[J]. Chin J Exp Ophthalmol, 2013, 31(1): 17-18. DOI: 10.3760/cma.j.issn.2095-0160.2013.01.004.
24.	Verdina T, Giacomelli G, Sodi A, et al. Biofeedback rehabilitation of eccentric fixation in patients with Stargardt disease[J]. Eur J Ophthalmol, 23(5): 723-731. DOI: 10.5301/ejo.5000291.
25.	Scuderi G, Verboschi F, Domanico D, et al. Fixation improvement through biofeedback rehabilitation in Stargardt disease[J/OL]. Case Rep Med, 2016, 2016: 4264829[2016-04-24]. https://pubmed.ncbi.nlm.nih.gov/27212950/. DOI: 10.1155/2016/4264829.
26.	Yokoi T, Ohno-Matsui K. Diagnosis and treatment of myopic maculopathy[J]. Asia Pac J Ophthalmol (Phila), 2018, 7(6): 415-421. DOI: 10.22608/APO.2018290.
27.	Vingolo EM, Salvatore S, Domanico D, et al. Visual rehabilitation in patients with myopic maculopathy: our experience[J]. Can J Ophthalmol, 2013, 48(5): 438-442. DOI: 10.1016/j.jcjo.2013.08.004.
28.	Pacella E, Pacella F, Mazzeo F, et al. Effectiveness of vision rehabilitation treatment through MP-1 microperimeter in patients with visual loss due to macular disease[J]. Clin Ter, 2012, 163(6): 423-428.
29.	Parravano M, Giansanti F, Eandi CM, et al. Vitrectomy for idiopathic macular hole[J/OL]. Cochrane Database Syst Rev, 2015(5): CD009080[2015-05-12]. https://pubmed.ncbi.nlm.nih.gov/25965055/. DOI: 10.1002/14651858.CD009080.pub2.
30.	Ueda-Consolvo T, Mitsuya O, Yumiko H, et al. Microperimetric biofeedback training improved visual acuity after successful macular hole surgery[J/OL]. J Ophthalmol, 2015, 2015: 572942[2015-12-13]. https://pubmed.ncbi.nlm.nih.gov/26783452/. DOI: 10.1155/2015/572942.

1. Mitchell P, Liew G, Gopinath B, et al. Age-related macular degeneration[J]. Lancet, 2018, 392(10153): 1147-1159. DOI: 10.1016/S0140-6736(18)31550-2.
2. Kumar A, Chawla R, Kumawat D, et al. Insight into high myopia and the macula[J]. Indian J Ophthalmol, 2017, 65(2): 85-91. DOI: 10.4103/ijo.IJO_863_16.
3. Tsang SH, Sharma T. Stargardt disease[J]. Adv Exp Med Biol, 2018, 1085: 139-151. DOI: 10.1007/978-3-319-95046-4_27.
4. Samoylov AN, Khaibrakhmanov TR, Fazleeva GA, et al. Idiopathic macular hole: history and status quo review[J]. Vestn Oftalmol, 2017, 133(6): 131-137. DOI: 10.17116/oftalma20171336131-137.
5. Vingolo EM, Napolitano G, Fragiotta S. Microperimetric biofeedback training: fundamentals, strategies and perspectives[J]. Front Biosci (Schol Ed), 2018, 10: 48-64. DOI: 10.2741/s500.
6. Dario G, Contestabile MT, Pacella E, et al. An instrument for biofeedback applied to vision[J]. Appl Psychophysiol Biofeedback, 2005, 30(4): 389-395. DOI: 10.1007/s10484-005-8424-1.
7. Cassels NK, John MW, Margrain TH, et al. The use of microperimetry in assessing visual function in age-related macular degeneration[J]. Surv Ophthalmol, 2018, 63(1): 40-55. DOI: 10.1016/j.survophthal.2017.05.007.
8. Wang JW, Jie CH, Tao YJ, et al. Macular integrity assessment to determine the association between macular microstructure and functional parameters in diabetic macular edema[J]. Int J Ophthalmol, 2018, 11(7): 1185-1191. DOI: 10.18240/ijo.2018.07.18.
9. Cheung SH, Legge GE. Functional and cortical adaptations to central vision loss[J]. Visual Neuroscience, 2005, 22(2): 187-201. DOI: 10.1017/S0952523805222071.
10. Morales MU, Saker S, Mehta RL, et al. Preferred retinal locus profile during prolonged fixation attempts[J]. Can J Ophthalmol, 2013, 48(5): 368-374. DOI: 10.1016/j.jcjo.2013.05.022.
11. Markowitz SN, Sophia VR. Microperimetry and clinical practice: an evidence-based review[J]. Can J Ophthalmol, 2013, 48(5): 350-357. DOI: 10.1016/j.jcjo.2012.03.004.
12. Tarita-Nistor L, González EG, Markowitz SN, et al. Plasticity of fixation in patients with central vision loss[J]. Vis Neurosci, 2009, 26(5-6): 487-494. DOI: 10.1017/S0952523809990265.
13. Chiang WY, Lee JJ, Chen YH, et al. Fixation behavior in macular dystrophy assessed by microperimetry[J]. Graefe’s Arch Clin Exp Ophthalmol, 2018, 256(8): 1403-1410. DOI: 10.1007/s00417-018-4006-9.
14. Mandelcorn MS, Podbielski DW, Mandelcorn ED. Fixation stability as a goal in the treatment of macular disease[J]. Can J Ophthalmol, 2013, 48(5): 364-367. DOI: 10.1016/j.jcjo.2013.05.006.
15. Molina-Martín A, Pérez-Cambrodí RJ, Piñero DP. Current clinical application of microperimetry: a review[J]. Semin Ophthalmol, 2018, 33(5): 620-628. DOI: 10.1080/08820538.2017.1375125.
16. Timberlake GT, Sharma MK, Grose SA, et al. Retinal location of the preferred retinal locus relative to the fovea in scanning laser ophthalmoscope images[J]. Optom Vis Sci, 2005, 82(3): 177-185. DOI: 10.1097/01.opx.0000156311.49058.c8.
17. Wong EN, Mackey DA, Morgan WH, et al. Inter-device comparison of retinal sensitivity measurements: the CenterVue MAIA and the Nidek MP-1[J]. Clin Exp Ophthalmol, 2016, 44(1): 15-23. DOI: 10.1111/ceo.12629.
18. Hernández-Zimbrón LF, Zamora-Alvarado R, Ochoa-De La Paz L, et al. Age-related macular degeneration: new paradigms for treatment and management of AMD[J/OL]. Oxid Med Cell Longev, 2018, 2018: 8374647[2018-02-01]. https://pubmed.ncbi.nlm.nih.gov/29484106/. DOI: 10.1155/2018/8374647.
19. Hanout M, Horan N, Do DV. Introduction to microperimetry and its use in analysis of geographic atrophy in age-related macular degeneration[J]. Curr Opin Ophthalmol, 2015, 26(3): 149-156. DOI: 10.1097/ICU.0000000000000153.
20. Vingolo EM, Cavarretta S, Domanico D, et al. Microperimetric biofeedback in AMD patients[J]. Appl Psychophysiol Biofeedback, 2007, 32(3): 185-189. DOI: 10.1007/s10484-007-9038-6.
21. Barboni MTS, Récsán Z, Szepessy Z, et al. Preliminary findings on the optimization of visual performance in patients with age-related macular degeneration using biofeedback training[J]. Appl Psychophysiol Biofeedback, 2019, 44(1): 61-70. DOI: 10.1007/s10484-018-9423-3.
22. Ramírez Estudillo JA, León Higuera MI, Rojas Juárez S, et al. Visual rehabilitation via microperimetry in patients with geographic atrophy: a pilot study[J/OL]. Int J Retina Vitreous, 2017, 3: 21[2017-05-22]. https://pubmed.ncbi.nlm.nih.gov/28536656/. DOI: 10.1186/s40942-017-0071-1.
23. 李娟娟, 张书林, 黎铧, 等. Stargardt病不同阶段荧光素眼底血管造影的临床观察[J]. 中华实验眼科杂志, 2013, 31(1): 17-18. DOI: 10.3760/cma.j.issn.2095-0160.2013.01.004.Li JJ, Zhang SL, Li H, et al. Clinical observation of fundus fluorescein angiography in different stages of Stargardt disease[J]. Chin J Exp Ophthalmol, 2013, 31(1): 17-18. DOI: 10.3760/cma.j.issn.2095-0160.2013.01.004.
24. Verdina T, Giacomelli G, Sodi A, et al. Biofeedback rehabilitation of eccentric fixation in patients with Stargardt disease[J]. Eur J Ophthalmol, 23(5): 723-731. DOI: 10.5301/ejo.5000291.
25. Scuderi G, Verboschi F, Domanico D, et al. Fixation improvement through biofeedback rehabilitation in Stargardt disease[J/OL]. Case Rep Med, 2016, 2016: 4264829[2016-04-24]. https://pubmed.ncbi.nlm.nih.gov/27212950/. DOI: 10.1155/2016/4264829.
26. Yokoi T, Ohno-Matsui K. Diagnosis and treatment of myopic maculopathy[J]. Asia Pac J Ophthalmol (Phila), 2018, 7(6): 415-421. DOI: 10.22608/APO.2018290.
27. Vingolo EM, Salvatore S, Domanico D, et al. Visual rehabilitation in patients with myopic maculopathy: our experience[J]. Can J Ophthalmol, 2013, 48(5): 438-442. DOI: 10.1016/j.jcjo.2013.08.004.
28. Pacella E, Pacella F, Mazzeo F, et al. Effectiveness of vision rehabilitation treatment through MP-1 microperimeter in patients with visual loss due to macular disease[J]. Clin Ter, 2012, 163(6): 423-428.
29. Parravano M, Giansanti F, Eandi CM, et al. Vitrectomy for idiopathic macular hole[J/OL]. Cochrane Database Syst Rev, 2015(5): CD009080[2015-05-12]. https://pubmed.ncbi.nlm.nih.gov/25965055/. DOI: 10.1002/14651858.CD009080.pub2.
30. Ueda-Consolvo T, Mitsuya O, Yumiko H, et al. Microperimetric biofeedback training improved visual acuity after successful macular hole surgery[J/OL]. J Ophthalmol, 2015, 2015: 572942[2015-12-13]. https://pubmed.ncbi.nlm.nih.gov/26783452/. DOI: 10.1155/2015/572942.

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