Assessment of choroidal vascularity index in healthy eyes of different subfoveal choroidal areas on enhanced depth imaging optical coherence tomography_Chinese Journal of Ocular Fundus Diseases

Authors：

Guo Qihan ¹ , Li Shuang ² ,  Wang Kang ²

1. School of Clinical Medicine, Capital Medial University, Beijing 100069, China;
2. Department of Ophtalmology, Beijing Friendship Hospital Affiliated to Capital Medical University, Beijing 100050, China;

Corresponding author：

Wang Kang, Email: bmbn2000@163.com

Keywords：

Tomography, optical coherence; Healthy eyes; Choroidal vascularity index

DOI：

10.3760/cma.j.cn511434-20190903-00278

Video：

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Objective To observe the effect of spectral-domain OCT with different subfoveal choroidal areas on choroid vascular index (CVI) in normal healthy eyes.Methods Retrospective clinical study. From October 2017 to May 2018, 174 eyes of 87 healthy people who visited in the Ophthalmology Department of Beijing Friendship Hospital and had no eye abnormalities were included in the study. All patients received single line scan of macular fovea by enhanced depth imaging OCT. After binary processing of the collected choroidal images, CVI as the center radius of 750, 1500, 3000 and 4500 μm were calculated. Repeated measurement analysis of variance was performed for comparison of CVI between groups.Results The mean values of CVI in the 750, 1500, 3000 and 4500 μm groups were 0.681±0.003, 0.678±0.002, 0.677±0.002 and 0.676±0.002, respectively. The difference between the 750 μm group and the 4500 μm group was 0.005±0.002 (P=0.009). The other pairwise comparison results showed no statistically significant difference (P＞0.05).Conclusion The CVI is different in healthy eyes with the different distance from macular fovea.

Citation： Guo Qihan, Li Shuang, Wang Kang. Assessment of choroidal vascularity index in healthy eyes of different subfoveal choroidal areas on enhanced depth imaging optical coherence tomography. Chinese Journal of Ocular Fundus Diseases, 2020, 36(5): 366-369. doi: 10.3760/cma.j.cn511434-20190903-00278 Copy

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11.	Wang NK, Lai CC, Chu HY, et al. Classification of early dry-type myopic maculopathy with macular choroidal thickness[J]. Am J Ophthalmol, 2012, 153(4): 669-677. DOI: 10.1016/j.ajo.2011.08.039.
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14.	Campos A, Campos EJ, Martins J, et al. Viewing the choroid: where we stand, challenges and contradictions in diabetic retinopathy and diabetic macular oedema[J]. Acta Ophthalmol, 2017, 95(5): 446-459. DOI: 10.1111/aos.13210.
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16.	韩鹏飞, 倪宇馨, 李双农. 糖尿病脉络膜病变的临床研究进展[J]. 中国中医眼科杂志, 2015, 25(5): 377-380. DOI: 10.13444/j.cnki.zgzyykzz.2015.05.022.Han PF, Ni YX, Li SN. Clinical research advances of diabetic choroidopathy[J]. Chinese Journal of Chinese Ophthalmology, 2015, 25(5): 377-380. DOI: 10.13444/j.cnki.zgzyykzz.2015.05.022.
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1. Alm A, Bill A. Ocular and optic nerve blood flow at normal and increased intraocular pressures in monkeys (Macaca irus): a study with radioactively labelled microspheres including flow determinations in brain and some other tissues[J]. Exp Eye Res, 1973, 15(1): 15-29. DOI: 10.1016/0014-4835(73)90185-1.
2. Wei X, Sonoda S, Mishra C, et al. Comparison of choroidal vascularity markers on optical coherence tomography using two-image binarization techniques[J]. Invest Ophthalmol Vis Sci, 2018, 59(3): 1206-1211. DOI: 10.1167/iovs.17-22720.
3. 王薇, 李爽, 李红阳, 等. 急性中心性浆液性脉络膜视网膜病变患者脉络膜血管指数及中心凹下脉络膜厚度测量分析[J]. 中华眼底病杂志, 2019, 35(4): 353-357. DOI: 10.3760/cma.j.issn.1005-1015.2019.04.008.Wang W, Li S, Li HY, et al. Measurement and analysis of choroidal vascularity index and subfoveal choroidal thickness in central serous chorioretinopathy[J]. Chin J Ocul Fundus Dis, 2019, 35(4): 353-357. DOI: 10.3760/cma.j.issn.1005-1015.2019.04.008.
4. 孙晓丽, 丛春霞, 李立, 等. 光相干断层扫描血管成像与传统多模式眼底成像对渗出型老年性黄斑变性脉络膜新生血管诊断与活动性判断的对比观察[J]. 中华眼底病杂志, 2017, 33(1): 10-14. DOI: 10.3760/cma.j.issn.1005-1015.2017.01.0044.Sun XL, Cong CX, Li L, et al. Optical coherence tomography angiography and traditional multimodal fundus imaging in the diagnosis and activity evaluation of choroidal neovascularization in exudative age-related macular degeneration[J]. Chin J Ocul Fundus Dis, 2017, 33(1): 10-14. DOI: 10.3760/cma.j.issn.1005-1015.2017.01.0044.
5. 郎需强, 王康, 李爽, 等. 脉络膜血管指数在视网膜中央静脉阻塞治疗预后评估中价值初步分析[J]. 临床眼科杂志, 2019, 27(4): 298-303. DOI: 10.3969/j.issn.1006-8422.Lang XQ, Wang K, Li S, et al. A pilot study of choroidal vascularity index as a predictor for treatment outcomes in central retinal vein occlu-sion[J]. J Clin Ophthalmol, 2019, 27(4): 298-303. DOI: 10.3969/j.issn.1006-8422.
6. Agrawal R, Gupta P, Tan KA, et al. Choroidal vascularity index as a measure of vascular status of the choroid: measurements in healthy eyes from a population-based study[J/OL]. Sci Rep, 2016, 6: 21090[2016-02-12]. https://www.nature.com/articles/srep21090. DOI: 10.1038/srep21090.
7. Hayreh SS. Posterior ciliary artery circulation in health and disease: the Weisenfeld lecture[J]. Invest Ophthalmol Vis Sci, 2004, 45(3): 749-757. DOI: 10.1167/iovs.03-0469.
8. Sonoda S, Sakamoto T, Yamashita T, et al. Luminal and stromal areas of choroid determined by binarization method of optical coherence tomographic images[J]. Am J Ophthalmol, 2015, 159(6): 1123-1131. DOI: 10.1016/j.ajo.2015.03.005.
9. 刘然, 晏颖, 陈晓. 颈内动脉狭窄患者的脉络膜厚度和脉管指数的改变[J]. 国际眼科杂志, 2020, 20(3): 533-536. DOI: 10.3980/j.issn.1672-5123.Liu R, Yan Y, Chen X. Changes of choroidal thickness and vascular index in patients with internal carotid artery stenosis[J]. Int Eye Sci, 2020, 20(3): 533-536. DOI: 10.3980/j.issn.1672-5123.
10. Agrawal R, Wei X, Goud A, et al. Influence of scanning area on choroidal vascularity index measurement using optical coherence tomography[J]. Acta Ophthalmol, 2017, 95(8): 770-775. DOI: 10.1111/aos.13442.
11. Wang NK, Lai CC, Chu HY, et al. Classification of early dry-type myopic maculopathy with macular choroidal thickness[J]. Am J Ophthalmol, 2012, 153(4): 669-677. DOI: 10.1016/j.ajo.2011.08.039.
12. Tan CS, Ngo WK, Cheong KX. Comparison of choroidal thicknesses using swept source and spectral domain optical coherence tomography in diseased and normal eyes[J]. Br J Ophthalmol, 2015, 99(3): 354-358. DOI: 10.1136/bjo.79.1.1.
13. Unsal E, Eltutar K, Zirtiloğlu S, et al. Choroidal thickness in patients with diabetic retinopathy[J]. Clin Ophthalmol, 2014, 8: 637-642. DOI: 10.2147/OPTH.S59395.
14. Campos A, Campos EJ, Martins J, et al. Viewing the choroid: where we stand, challenges and contradictions in diabetic retinopathy and diabetic macular oedema[J]. Acta Ophthalmol, 2017, 95(5): 446-459. DOI: 10.1111/aos.13210.
15. Wallman J, Nickla DL. The multifunctional choroid[J]. Prog Retin Eye Res, 2010, 29(2): 144-168. DOI: 10.1016/j.preteyeres.2009.12.002.
16. 韩鹏飞, 倪宇馨, 李双农. 糖尿病脉络膜病变的临床研究进展[J]. 中国中医眼科杂志, 2015, 25(5): 377-380. DOI: 10.13444/j.cnki.zgzyykzz.2015.05.022.Han PF, Ni YX, Li SN. Clinical research advances of diabetic choroidopathy[J]. Chinese Journal of Chinese Ophthalmology, 2015, 25(5): 377-380. DOI: 10.13444/j.cnki.zgzyykzz.2015.05.022.
17. Schindelin J, Arganda-Carreras I, Frise E, et al. Fiji: an open-source platform for biological-image analysis[J]. Nat Methods, 2012, 9(7): 676-682. DOI: 10.1038/nmeth.2019.
18. Xin W, Shozo S, Chitaranjan M, et al. Comparison of choroidal vascularity markers on optical coherence tomography using two-image binarization techniques[J]. Invest Opthalmol Vis Sci, 2018, 59(3): 1206-1211. DOI: 10.1038/eye.2013.78.

Chinese Journal of Ocular Fundus Diseases

Assessment of choroidal vascularity index in healthy eyes of different subfoveal choroidal areas on enhanced depth imaging optical coherence tomography

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