Quantitive analysis of the choriocapillaris flow density and choroidal vessel volume of acute and chronic central serous chorioretinopathy_Chinese Journal of Ocular Fundus Diseases

Authors：

Zhang Yifan , Gao Yuzhu , Xu Hanyue ,  Zhang Ming

Department of Ophthalmology, West China Hospital, Sichuan University, Chengdu 610041, China;

Corresponding author：

Zhang Ming, Email: mingzhangscu@163.com

Keywords：

Central serous chorioretinopathy; Tomography, optical coherence; Regional blood flow; Choriocapillaris; Choroidal vessel volume

DOI：

10.3760/cma.j.cn511434-20210119-00037

Video：

Export PDF Favorites Scan Get Citation

Abstract Full text Figures/Tables Video References Cited by

Objective To compare the choriocapillaris flow density and choroidal vessel volume (CVV) of acute and chronic central serous chorioretinopathy (CSC).Methods A cross-sectional observational clinical study. A total of 64 eyes of 64 patients (CSC group) diagnosed with CSC at Department of Ophthalmology of West China Hospital of Sichuan University from May 2019 to October 2020, and a total of 64 eyes of 64 age and gender matched healthy volunteers (control group) during the same period were included in this study. In the CSC group, there were 34 patients with acute CSC (acute CSC group) and 30 patients with chronic CSC (chronic CSC group). There was no significant difference in age (t=－0.041) and sex composition ratio (χ²=0.191) between CSC group and control group (P＞0.05). There were statistically significant differences in age (t=－1.872) and sex composition ratio (χ²=8.778) between acute CSC group and chronic CSC group (P＜0.05). Swept source optical coherence tomography angiography (SS-OCTA) was performed using VG200D. The scanning mode was 512×512 and scannig range was 12 mm × 12 mm. The choriocapillaris flow density of the 3 mm, 6 mm, 12 mm circular area and 1-3 mm ring, 3-6 mm ring, and 6-12 mm ring, and the CVV of the of the 3 mm, 6 mm, 12 mm circular area was automatically generated by the built-in software (v1.28.6). The age, choriocapillaris flow density and CVV were compared between two groups using independent sample t test.Results Compared with the control group, the choriocapillaris flow density decreased in the CSC group, and there were statistically significant differences in the 3 mm, 6 mm circular area (t=－7.210, －4.040; P＜0.001). There were statistically significant differences between CSC group and control group in the 3 mm, 6 mm, 12 mm circular area (t=1.460, 12.270, 11.250; P＜0.05). Compared with the acute CSC group, the choriocapillaris flow density decreased in the chronic CSC group, and there were statistically significant differences (P＜0.05) in the 3 mm, 6 mm circular area (t=3.230, 2.330), the total and four quadrants of 1-3 mm ring (t=2.780, 2.060, 2.140, 2.620, 3.770), the superior quadrants of the 3-6 mm ring (t=2.550), and the superior and temporal of 6-12 mm ring (t=3.070, 2.610). There was no significant difference of CVV in the 3 mm, 6 mm and 12 mm circular area between the acute CSC group and the chronic CSC group (t=0.250, 0.070, －0.110; P＞0.05).Conclusion Compared with acute CSC, chronic CSC exhibits significant decreased choriocapillaris flow density and no change in CVV.

Citation： Zhang Yifan, Gao Yuzhu, Xu Hanyue, Zhang Ming. Quantitive analysis of the choriocapillaris flow density and choroidal vessel volume of acute and chronic central serous chorioretinopathy. Chinese Journal of Ocular Fundus Diseases, 2021, 37(2): 122-126. doi: 10.3760/cma.j.cn511434-20210119-00037 Copy

1.	Gass JD. Pathogenesis of disciform detachment of the neuroepithelium[J]. Am J Ophthalmol, 1967, 63(3): Suppl: 1-139.
2.	Yannuzzi LA, Shakin JL, Fisher YL, et al. Peripheral retinal detachments and retinal pigment epithelial atrophic tracts secondary to central serous pigment epitheliopathy[J]. Retina, 2012, 32 Suppl 1: 1554-1572. DOI: 10.1097/iae.0b013e3182434da4.
3.	Warrow DJ, Hoang QV, Freund KB. Pachychoroid pigment epitheliopathy[J]. Retina, 2013, 33(8): 1659-1672. DOI: 10.1097/IAE.0b013e3182953df4.
4.	Lim LS, Cheung G, Lee SY. Comparison of spectral domain and swept-source optical coherence tomography in pathological myopia[J]. Eye(Lond), 2014, 28(4): 488-491. DOI: 10.1038/eye.2013.308.
5.	Copete S, Flores-Moreno I, Montero JA, et al. Direct comparison of spectral-domain and swept-source OCT in the measurement of choroidal thickness in normal eyes[J]. Br J Ophthalmol, 2014, 98(3): 334-338. DOI: 10.1136/bjophthalmol-2013-303904.
6.	Lavinsky D, Palanker D. Nondamaging photothermal therapy for the retina: initial clinical experience with chronic central serous retinopathy[J]. Retina, 2015, 35(2): 213-222. DOI: 10.1097/IAE.0000000000000340.
7.	Lotery A, Sivaprasad S, O'Connell A, et al. Eplerenone for chronic central serous chorioretinopathy in patients with active, previously untreated disease for more than 4 months (VICI): a randomised, double-blind, placebo-controlled trial[J]. Lancet, 2020, 395(10220): 294-303. DOI: 10.1016/S0140-6736(19)32981-2.
8.	李加青, 丁小燕, 曾婧, 等. 慢性中心性浆液性脉络膜视网膜病变患者双眼脉络膜厚度频域光相干断层扫描检查分析[J]. 中华眼底病杂志, 2012, 28(4): 325-328. DOI: 10.3760/cma.j.issn.1005-1015.2012.04.003.Li JQ, Ding XY, Zeng J, et al. Choroidal thickness of chronic central serous chorioretinopathy with spectral-domain optical coherence tomography[J]. Chin J Ocul Fundus Dis, 2012, 28(4): 325-328. DOI: 10.3760/cma.j.issn.1005-1015.2012.04.003.
9.	Yang J, Wang E, Yuan M, et al. Three-dimensional choroidal vascularity index in acute central serous chorioretinopathy using swept-source optical coherence tomography[J]. Graefe's Arch Clin Exp Ophthalmol, 2020, 258(2): 241-247. DOI: 10.1007/s00417-019-04524-7.
10.	Tan CS, Ngo WK, Cheong KX. Comparison of choroidal thicknesses using swept source and spectral domain optical coherence tomography in diseased and normal eyes[J]. Br J Ophthalmol, 2015, 99(3): 354-358. DOI: 10.1136/bjophthalmol-2014-305331.
11.	Ohayon A, Sacconi R, Semoun O, et al. Choroidal neovascular area and vessel density comparison between two swept-source optical coherence tomography angiography devices[J]. Retina, 2020, 40(3): 521-528. DOI: 10.1097/IAE.0000000000002430.
12.	Coulombre AJ. Experimental embryology of the vertebrate eye[J]. Invest Ophthalmol, 1965, 4: 411-419.
13.	Rochepeau C, Kodjikian L, Garcia MA, et al. Optical coherence tomography angiography quantitative assessment of choriocapillaris blood flow in central serous chorioretinopathy[J]. Am J Ophthalmol, 2018, 194: 26-34. DOI: 10.1016/j.ajo.2018.07.004.
14.	刘珏君, 陈长征, 徐奕爽, 等. 慢性中心性浆液性脉络膜视网膜病变患眼光动力疗法治疗前后脉络膜毛细血管变化特点[J]. 中华眼底病杂志, 2019, 35(4): 358-363. DOI: 10.3760/cma.j.issn.1005-1015.2019.04.009.Liu JJ, Chen CZ, Xu YS, et al. The changes of choriocapillaris blood flow in chronic central serous chorioretinopathy before and after photodynamic therapy[J]. Chin J Ocul Fundus Dis, 2019, 35(4): 358-363. DOI: 10.3760/cma.j.issn.1005-1015.2019.04.009.
15.	Ma DJ, Park UC, Kim ET, et al. Choroidal vascularity changes in idiopathic central serous chorioretinopathy after half-fluence photodynamic therapy[J/OL]. PLoS One, 2018, 13(8): e0202930[2018-08-27]. http://europepmc.org/article/MED/30148858. DOI: 10.1371/journal.pone.0202930.

1. Gass JD. Pathogenesis of disciform detachment of the neuroepithelium[J]. Am J Ophthalmol, 1967, 63(3): Suppl: 1-139.
2. Yannuzzi LA, Shakin JL, Fisher YL, et al. Peripheral retinal detachments and retinal pigment epithelial atrophic tracts secondary to central serous pigment epitheliopathy[J]. Retina, 2012, 32 Suppl 1: 1554-1572. DOI: 10.1097/iae.0b013e3182434da4.
3. Warrow DJ, Hoang QV, Freund KB. Pachychoroid pigment epitheliopathy[J]. Retina, 2013, 33(8): 1659-1672. DOI: 10.1097/IAE.0b013e3182953df4.
4. Lim LS, Cheung G, Lee SY. Comparison of spectral domain and swept-source optical coherence tomography in pathological myopia[J]. Eye(Lond), 2014, 28(4): 488-491. DOI: 10.1038/eye.2013.308.
5. Copete S, Flores-Moreno I, Montero JA, et al. Direct comparison of spectral-domain and swept-source OCT in the measurement of choroidal thickness in normal eyes[J]. Br J Ophthalmol, 2014, 98(3): 334-338. DOI: 10.1136/bjophthalmol-2013-303904.
6. Lavinsky D, Palanker D. Nondamaging photothermal therapy for the retina: initial clinical experience with chronic central serous retinopathy[J]. Retina, 2015, 35(2): 213-222. DOI: 10.1097/IAE.0000000000000340.
7. Lotery A, Sivaprasad S, O'Connell A, et al. Eplerenone for chronic central serous chorioretinopathy in patients with active, previously untreated disease for more than 4 months (VICI): a randomised, double-blind, placebo-controlled trial[J]. Lancet, 2020, 395(10220): 294-303. DOI: 10.1016/S0140-6736(19)32981-2.
8. 李加青, 丁小燕, 曾婧, 等. 慢性中心性浆液性脉络膜视网膜病变患者双眼脉络膜厚度频域光相干断层扫描检查分析[J]. 中华眼底病杂志, 2012, 28(4): 325-328. DOI: 10.3760/cma.j.issn.1005-1015.2012.04.003.Li JQ, Ding XY, Zeng J, et al. Choroidal thickness of chronic central serous chorioretinopathy with spectral-domain optical coherence tomography[J]. Chin J Ocul Fundus Dis, 2012, 28(4): 325-328. DOI: 10.3760/cma.j.issn.1005-1015.2012.04.003.
9. Yang J, Wang E, Yuan M, et al. Three-dimensional choroidal vascularity index in acute central serous chorioretinopathy using swept-source optical coherence tomography[J]. Graefe's Arch Clin Exp Ophthalmol, 2020, 258(2): 241-247. DOI: 10.1007/s00417-019-04524-7.
10. Tan CS, Ngo WK, Cheong KX. Comparison of choroidal thicknesses using swept source and spectral domain optical coherence tomography in diseased and normal eyes[J]. Br J Ophthalmol, 2015, 99(3): 354-358. DOI: 10.1136/bjophthalmol-2014-305331.
11. Ohayon A, Sacconi R, Semoun O, et al. Choroidal neovascular area and vessel density comparison between two swept-source optical coherence tomography angiography devices[J]. Retina, 2020, 40(3): 521-528. DOI: 10.1097/IAE.0000000000002430.
12. Coulombre AJ. Experimental embryology of the vertebrate eye[J]. Invest Ophthalmol, 1965, 4: 411-419.
13. Rochepeau C, Kodjikian L, Garcia MA, et al. Optical coherence tomography angiography quantitative assessment of choriocapillaris blood flow in central serous chorioretinopathy[J]. Am J Ophthalmol, 2018, 194: 26-34. DOI: 10.1016/j.ajo.2018.07.004.
14. 刘珏君, 陈长征, 徐奕爽, 等. 慢性中心性浆液性脉络膜视网膜病变患眼光动力疗法治疗前后脉络膜毛细血管变化特点[J]. 中华眼底病杂志, 2019, 35(4): 358-363. DOI: 10.3760/cma.j.issn.1005-1015.2019.04.009.Liu JJ, Chen CZ, Xu YS, et al. The changes of choriocapillaris blood flow in chronic central serous chorioretinopathy before and after photodynamic therapy[J]. Chin J Ocul Fundus Dis, 2019, 35(4): 358-363. DOI: 10.3760/cma.j.issn.1005-1015.2019.04.009.
15. Ma DJ, Park UC, Kim ET, et al. Choroidal vascularity changes in idiopathic central serous chorioretinopathy after half-fluence photodynamic therapy[J/OL]. PLoS One, 2018, 13(8): e0202930[2018-08-27]. http://europepmc.org/article/MED/30148858. DOI: 10.1371/journal.pone.0202930.

Chinese Journal of Ocular Fundus Diseases

Quantitive analysis of the choriocapillaris flow density and choroidal vessel volume of acute and chronic central serous chorioretinopathy

Abstract Full text Figures/Tables Video References Cited by

Previous Article

Next Article

Format

Content