Research progress of circular RNA in ocular fundus diseases_Chinese Journal of Ocular Fundus Diseases

Authors：

Wang Ying , Chen Xue ,  Liu Qinghuai

Department of Ophthalmology, The First Affiliated Hospital of Nanjing Medical University, Nanjing Medical University, Nanjing 210029, China;

Corresponding author：

Liu Qinghuai, Email: liuqh@njmu.edu.cn

Keywords：

RNA; Retinal diseases; Diabetic retinopathy; Eye neoplasms; Review

DOI：

10.3760/cma.j.cn511434-20210218-00082

Video：

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Abstract Full text Figures/Tables Video References Cited by

Circular RNA (circRNA) is a new group of endogenous non-coding RNAs produced by back-splicing, which has multiple molecular functions such as acting as microRNA sponges, regulators of transcription and splicing, adaptors for protein-protein interaction. Recent studies have shown that circRNA play an essential role in development and progression of retinal microvascular dysfunction, diabetic retinopathy, age-related macular degeneration, proliferative vitreoretinopathy, eye diseases caused by hyperhomocysteine and ocular malignancy. In pathological conditions, the differential expression of circRNA alters the transcription and translation of corresponding genes, thus changing the activity and function of cells. CircRNA may become a new marker and prognostic indicator of fundus diseases, and its targeted intervention may also become a potential treatment for fundus diseases.

Citation： Wang Ying, Chen Xue, Liu Qinghuai. Research progress of circular RNA in ocular fundus diseases. Chinese Journal of Ocular Fundus Diseases, 2022, 38(4): 334-339. doi: 10.3760/cma.j.cn511434-20210218-00082 Copy

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30. Cheng J, Liu Q, Hu N, et al. Downregulation of hsa_circ_0068087 ameliorates TLR4/NF-κB/NLRP3 inflammasome-mediated inflammation and endothelial cell dysfunction in high glucose conditioned by sponging miR-197[J]. Gene, 2019, 709: 1-7. DOI: 10.1016/j.gene.2019.05.012.
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