Research progress of pyroptosis in the pathogenesis of retinal diseases_Chinese Journal of Ocular Fundus Diseases

Authors：

Li Xinyu ¹ , Jiang Feng ² ,  Wang Ying ^1,3

1. Aier School of Ophthalmology, Central South University, Changsha 410015, China;
2. Department of Ophthalmology, Tianjin Medical University General Hospital, Tianjin 300052, China;
3. Shenyang Aier Eye Hospital, Shenyang 110000, China;

Corresponding author：

Wang Ying, Email: 35953532@qq.com

Keywords：

Pyroptosis; Diabetic retinopathy; Macular degeneration; Review

DOI：

10.3760/cma.j.cn511434-20210409-00187

Video：

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Abstract Full text Figures/Tables Video References Cited by

Pyroptosis is an inflammatory form of programmed cell death, including canonical and non-canonical pyroptosis pathway. Studies on pyroptosis have been reported in a variety of retinal diseases, but they are more focused on common diseases such as diabetic retinopathy and age-related macular degeneration. Many retinal diseases are difficult to treat because of the complexity of their etiology and pathogenesis. The discovery of pyroptosis has brought new content to the pathogenesis of these diseases, and also pointed a new direction for the treatment. Pyroptosis does not occur independently, and it is related to apoptosis and autophagy, but the specific mechanism is not clear. However, the most important biomolecule in the process of pyroptosis have been basically determined, and some methods can be used to interfere with pyroptosis, which has obtained preliminary achievement, suggesting that inhibition of pyroptosis may be a new direction for the treatment of retinal diseases and has broad research prospects.

Citation： Li Xinyu, Jiang Feng, Wang Ying. Research progress of pyroptosis in the pathogenesis of retinal diseases. Chinese Journal of Ocular Fundus Diseases, 2022, 38(11): 949-953. doi: 10.3760/cma.j.cn511434-20210409-00187 Copy

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2. Huang Z, Zhou T, Sun X, et al. Necroptosis in microglia contributes to neuroinflammation and retinal degeneration through TLR4 activation[J]. Cell Death Differ, 2017, 25(1): 180-189. DOI: 10.1038/cdd.2017.141.
3. Totsuka K, Ueta T, Uchida T, et al. Oxidative stress induces ferroptotic cell death in retinal pigment epithelial cells[J]. Exp Eye Res, 2019, 181: 316-324. DOI: 10.1016/j.exer.2018.08.019.
4. Riegman M, Sagie L, Galed C, et al. Ferroptosis occurs through an osmotic mechanism and propagates independently of cell rupture[J]. Nat Cell Biol, 2020, 22(9): 1042-1048. DOI: 10.1038/s41556-020-0565-1.
5. Yang M, So KF, Lam WC, et al. Novel programmed cell death as therapeutic targets in age-related macular degeneration?[J/OL]. Int J Mol Sci, 2020, 21(19): 7279[2020-10-01]. https://pubmed.ncbi.nlm.nih.gov/33019767/. DOI: 10.3390/ijms21197279.
6. Wu C, Lu W, Zhang Y, et al. Inflammasome activation triggers blood clotting and host death through pyroptosis[J]. Immunity, 2019, 50(6): 1401-1411. DOI: 10.1016/j.immuni.2019.04.003.
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8. Feng S, Fox D, Man SM. Mechanisms of gasdermin family members in inflammasome signaling and cell death[J]. J Mol Biol, 2018, 430(18 Pt B): 3068-3080. DOI: 10.1016/j.jmb.2018.07.002.
9. Man SM, Karki R, Kanneganti TD. Molecular mechanisms and functions of pyroptosis, inflammatory caspases and inflammasomes in infectious diseases[J]. Immunol Rev, 2017, 277(1): 61-75. DOI: 10.1111/imr.12534.
10. Platnich JM, Muruve DA. NOD-like receptors and inflammasomes: a review of their canonical and non-canonical signaling pathways[J]. Arch Biochem Biophys, 2019, 670: 4-14. DOI: 10.1016/j.abb.2019.02.008.
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12. Gan J, Huang M, Lan G, et al. High glucose induces the loss of retinal pericytes partly via NLRP3-Caspase-1-GSDMD-mediated pyroptosis[J/OL]. Biomed Res Int, 2020, 2020: 4510628[2020-04-23]. https://pubmed.ncbi.nlm.nih.gov/32420343/. DOI: 10.1155/2020/4510628.
13. Yu X, Ma X, Lin W, et al. Long noncoding RNA MIAT regulates primary human retinal pericyte pyroptosis by modulating miR-342-3p targeting of CASP1 in diabetic retinopathy[J/OL]. Exp Eye Res, 2021, 202: 108300[2021-01-01]. https://pubmed.ncbi.nlm.nih.gov/33065089/. DOI: 10.1016/j.exer.2020.108300.
14. Huang L, You J, Yao Y, et al. High glucose induces pyroptosis of retinal microglia through NLPR3 inflammasome signaling[J]. Arq Bras Oftalmol, 2021, 84(1): 67-73. DOI: 10.5935/0004-2749.20210010.
15. Chaurasia SS, Lim RR, Parikh BH, et al. The NLRP3 inflammasome may contribute to pathologic neovascularization in the advanced stages of diabetic retinopathy[J/OL]. Sci Rep, 2018, 8(1): 2847[2018-02-12]. https://pubmed.ncbi.nlm.nih.gov/29434227/. DOI: 10.1038/s41598-018-21198-z.
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18. Zha X, Xi X, Fan X, et al. Overexpression of METTL3 attenuates high-glucose induced RPE cell pyroptosis by regulating miR-25-3p/PTEN/Akt signaling cascade through DGCR8[J]. Aging (Albany NY), 2020, 12(9): 8137-8150. DOI: 10.18632/aging.103130.
19. Chen H, Zhang X, Liao N, et al. Enhanced expression of NLRP3 inflammasome-related inflammation in diabetic retinopathy[J]. Invest Ophthalmol Vis Sci, 2018, 59(2): 978-985. DOI: 10.1167/iovs.17-22816.
20. Liu Q, Zhang F, Zhang X, et al. Fenofibrate ameliorates diabetic retinopathy by modulating Nrf2 signaling and NLRP3 inflammasome activation[J]. Mol Cell Biochem, 2018, 445(1-2): 105-115. DOI: 10.1007/s11010-017-3256-x.
21. Shi H, Zhang Z, Wang X, et al. Inhibition of autophagy induces IL-1β release from ARPE-19 cells via ROS mediated NLRP3 inflammasome activation under high glucose stress[J]. Biochem Biophys Res Commun, 2015, 463(4): 1071-1076. DOI: 10.1016/j.bbrc.2015.06.060.
22. Li Y, Liu C, Wan XS, et al. NLRP1 deficiency attenuates diabetic retinopathy (DR) in mice through suppressing inflammation response[J]. Biochem Biophys Res Commun, 2018, 501(2): 351-357. DOI: 10.1016/j.bbrc.2018.03.148.
23. Gu C, Draga D, Zhou C, et al. MiR-590-3p inhibits pyroptosis in diabetic retinopathy by targeting NLRP1 and inactivating the NOX4 signaling pathway[J]. Invest Ophthalmol Vis Sci, 2019, 60(13): 4215-4223. DOI: 10.1167/iovs.19-27825.
24. Li W, Jin LY, Cui YB, et al. Human umbilical cord mesenchymal stem cells-derived exosomal microRNA-17-3p ameliorates inflammatory reaction and antioxidant injury of mice with diabetic retinopathy via targeting STAT1[J/OL]. Int Immunopharmacol, 2021, 90: 107010[2021-01-01]. https://pubmed.ncbi.nlm.nih.gov/33333415/. DOI: 10.1016/j.intimp.2020.107010.
25. Zhang W, Wang Y, Kong Y. Exosomes derived from mesenchymal stem cells modulate miR-126 to ameliorate hyperglycemia-induced retinal inflammation via targeting HMGB1[J]. Invest Ophthalmol Vis Sci, 2019, 60(1): 294-303. DOI: 10.1167/iovs.18-25617.
26. Kerur N, Fukuda S, Banerjee D, et al. cGAS drives noncanonical-inflammasome activation in age-related macular degeneration[J]. Nat Med, 2018, 24(1): 50-61. DOI: 10.1038/nm.4450.
27. Zhang W, Ma Y, Zhang Y, et al. Photo-oxidative blue-light stimulation in retinal pigment epithelium cells promotes exosome secretion and increases the activity of the NLRP3 inflammasome[J]. Curr Eye Res, 2019, 44(1): 67-75. DOI: 10.1080/02713683.2018.1518458.
28. He GH, Zhang W, Ma YX, et al. Mesenchymal stem cells-derived exosomes ameliorate blue light stimulation in retinal pigment epithelium cells and retinal laser injury by VEGF-dependent mechanism[J]. Int J Ophthalmol, 2018, 11(4): 559-566. DOI: 10.18240/ijo.2018.04.04.
29. Liao Y, Zhang H, He D, et al. Retinal pigment epithelium cell death is associated with NLRP3 inflammasome activation by all-trans retinal[J]. Invest Opthalmol Vis Sci, 2019, 60(8): 3034-3045. DOI: 10.1167/iovs.18-26360.
30. Gao J, Cui JZ, To E, et al. Evidence for the activation of pyroptotic and apoptotic pathways in RPE cells associated with NLRP3 inflammasome in the rodent eye[J]. J Neuroinflammation, 2018, 15(1): 15. DOI: 10.1186/s12974-018-1062-3.
31. Somasundaran S, Constable IJ, Mellough CB, et al. Retinal pigment epithelium and age-related macular degeneration: a review of major disease mechanisms[J]. Clin Exp Ophthalmol, 2020, 48(8): 1043-1056. DOI: 10.1111/ceo.13834.
32. Wooff Y, Fernando N, Wong JHC, et al. Caspase-1-dependent inflammasomes mediate photoreceptor cell death in photo-oxidative damage-induced retinal degeneration[J/OL]. Sci Rep, 2020, 10(1): 2263[2020-02-10]. https://pubmed.ncbi.nlm.nih.gov/32041990/. DOI: 10.1038/s41598-020-58849-z.
33. Malsy J, Alvarado AC, Lamontagne JO, et al. Distinct effects of complement and of NLRP3- and non-NLRP3 inflammasomes for choroidal neovascularization[J/OL]. Elife, 2020, 9: e60194[2020-12-11]. https://pubmed.ncbi.nlm.nih.gov/33305736/. DOI: 10.7554/eLife.60194.
34. Brandstetter C, Patt J, Holz FG, et al. Inflammasome priming increases retinal pigment epithelial cell susceptibility to lipofuscin phototoxicity by changing the cell death mechanism from apoptosis to pyroptosis[J]. J Photochem Photobiol B, 2016, 161: 177-183. DOI: 10.1016/j.jphotobiol.2016.05.018.
35. Sun HJ, Jin XM, Xu J, et al. Baicalin alleviates age-related macular degeneration via miR-223/NLRP3-regulated pyroptosis[J]. Pharmacology, 2020, 105(1-2): 28-38. DOI: 10.1159/000502614.
36. Yang M, So KF, Lo ACY, et al. The effect of lycium barbarum polysaccharides on pyroptosis-associated amyloid β_1-40 oligomers-induced adult retinal pigment epithelium 19 cell damage[J/OL]. Int J Mol Sci, 2020, 21(13): 4658[2020-06-30]. https://pubmed.ncbi.nlm.nih.gov/32629957/. DOI: 10.3390/ijms21134658.
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