The clinical effect of amniotic membrane patching in the treatment of recurrent macular hole associated with retinal detachment of high myopia_Chinese Journal of Ocular Fundus Diseases

Authors：

Liang Shenzhi , Dong Yichen ,  Wan Guangming , Qian Cheng , Wang Jiong , Dong Yi

Department of Ophthalmology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China;

Corresponding author：

Wan Guangming, Email: wgm6608@163.com

Keywords：

Retinal detachment; Retinal perforations; Myopia, degenerative; Amniotic membrane

DOI：

10.3760/cma.j.cn511434-20211015-00584

Video：

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Objective To evaluate the safety and efficacy of amniotic membrane patching in the treatment of recurrent macular hole associated with retinal detachment of high myopia (MHRD). Methods A prospective study. From March 2018 to January 2020, 11 patients (11 eyes) of recurrent macular hole associated with MHRD at the First Affiliated Hospital of Zhengzhou University were enrolled. Among them, there were 3 males (3 eyes), and 8 females (8 eyes). The average age was 63.64±5.82. The axis length (AL) was 29.10±0.59 mm, and the logarithm of the minimum angle of resolution best corrected visual acuity (logMAR BCVA) was 2.23±0.57. Patients previously received pars plana vitrectomy (PPV) combined with internal limiting membrane stripping surgery, which was more than 1 time. All eyes underwent standard pars plana three-channel 23G PPV combined with amniotic membrane covering and silicone oil filling. The silicone oil was removed 6 months after surgery. Follow-up time was up to 3 months after silicone oil removal surgery. 1, 3, and 6 months after the operation, the same equipment and methods were used to conduct relevant examinations before the operation to observe the closure of the macular hole, retinal reattachment and changes in logMAR BCVA. The logMAR BCVA before and after surgery was compared by paired t test. Results At 1, 3, and 6 months after the operation, the retinas of all eyes were anatomically repositioned, the macular holes were well closed, and the amniotic membrane was attached to the retina. At 3 months after the silicone oil removal operation, there was no recurrence of macular hole in all eyes; logMAR BCVA was 1.35±0.32. No serious complications occurred during and after surgery in all eyes. Conclusion Amniotic membrane patching is a safe and effective method for recurrent macular hole associated with MHRD.

Citation： Liang Shenzhi, Dong Yichen, Wan Guangming, Qian Cheng, Wang Jiong, Dong Yi. The clinical effect of amniotic membrane patching in the treatment of recurrent macular hole associated with retinal detachment of high myopia. Chinese Journal of Ocular Fundus Diseases, 2022, 38(6): 491-494. doi: 10.3760/cma.j.cn511434-20211015-00584 Copy

1.	Coppola M, Rabiolo A, Cicinelli MV, et al. Vitrectomy in high myopia: a narrative review[J/OL]. Int J Retina Vitreous, 2017, 3: 37[2017-10-02]. https://pubmed.ncbi.nlm.nih.gov/29021916/. DOI: 10.1186/s40942-017-0090-y.
2.	Lim LS, Tsai A, Wong D, et al. Prognostic factor analysis of vitrectomy for retinal detachment associated with myopic macular holes[J]. Ophthalmology, 2014, 121(1): 305-310. DOI: 10.1016/j.ophtha.2020.10.007.
3.	Wu TT, Kung YH. Comparison of anatomical and visual outcomes of macular hole surgery in patients with high myopia vs. non-high myopia: a case-control study using optical coherence tomography[J]. Graefe's Arch Clin Exp Ophthalmol, 2012, 250(3): 327-331. DOI: 10.1007/s00417-011-1821-7.
4.	Fernandes M, Sridhar MS, Sangwan VS, et al. Amniotic membrane transplantation for ocular surface reconstruction[J]. Cornea, 2005, 24(6): 643-653. DOI: 10.1097/01.ico.0000151501.80952.c5.
5.	Kiilgaard JF, Scherfig E, Prause JU, et al. Transplantation of amniotic membrane to the subretinal space in pigs[J/OL]. Stem Cells Int, 2012, 2012: 716968[2021-03-05]. https://pubmed.ncbi.nlm.nih.gov/22550516/. DOI: 10.13039/501100005929.
6.	Zhu D, Jin X, Zhou J. Transplantation of amniotic membrane for choroidal hole to treat suprachoroidal silicone oil migration[J/OL]. Acta Ophthalmol, 2017, 95(6): e522-e523[2017-07-11]. https://pubmed.ncbi.nlm.nih.gov/28696567/. DOI: 10.1111/aos.13516.
7.	Caporossi T, Angelis L, Pacini B, et al. A human amniotic membrane plug to manage high myopic macular hole associated with retinal detachment[J/OL]. Acta Ophthalmol, 2020, 98(2): e252-e256[2019-07-18]. https://pubmed.ncbi.nlm.nih.gov/31318489/. DOI: 10.1111/aos.14174.
8.	Takahashi H, Inoue M, Koto T, et al. Inverted internal limiting membrane flap technique for treatment of macular hole retinal detachment in highly myopic eyes[J]. Retina, 2018, 38(12): 2317-2326. DOI: 10.1097/IAE.0000000000001898.
9.	Hangai M, Ojima Y, Gotoh N, et al. Three-dimensional imaging of macular holes with high-speed optical coherence tomography[J]. Ophthalmology, 2007, 114(4): 763-773. DOI: 10.1016/j.ophtha.2006.07.055.
10.	Chen SN, Yang CM. Lens capsular flap transplantation in the management of refractory macular hole from multiple etiologies[J]. Retina, 2016, 36(1): 163-170. DOI: 10.1097/IAE.0000000000000674.
11.	Lai CC, Chen YP, Wang NK, et al. Vitrectomy with internal limiting membrane repositioning and autologous blood for macular hole retinal detachment in highly myopic eyes[J]. Ophthalmology, 2015, 122(9): 1889-1898. DOI: 10.1016/j.ophtha.2015.05.040.
12.	Grewal DS, Mahmoud TH. Autologous neurosensory retinal free flap for closure of refractory myopic macular holes[J]. JAMA Ophthalmol, 2016, 134(2): 229-230. DOI: 10.1001/jamaophthalmol.2015.5237.
13.	Di Tizio F, Gattazzo I, Di Staso F, et al. Human amniotic membrane patch and platelet-rich plasma to promote retinal hole repair in a recurrent retinal detachment[J]. Eur J Ophthalmol, 2021, 31(3): 1479-1482. DOI: 10.1177/1120672120953314.
14.	Moharram HM, Moustafa MT, Mortada HA, et al. Use of epimacular amniotic membrane graft in cases of recurrent retinal detachment due to failure of myopic macular hole closure[J]. Ophthalmic Surg Lasers Imaging Retina, 2020, 51(2): 101-108. DOI: 10.3928/23258160-20200129-06.

1. Coppola M, Rabiolo A, Cicinelli MV, et al. Vitrectomy in high myopia: a narrative review[J/OL]. Int J Retina Vitreous, 2017, 3: 37[2017-10-02]. https://pubmed.ncbi.nlm.nih.gov/29021916/. DOI: 10.1186/s40942-017-0090-y.
2. Lim LS, Tsai A, Wong D, et al. Prognostic factor analysis of vitrectomy for retinal detachment associated with myopic macular holes[J]. Ophthalmology, 2014, 121(1): 305-310. DOI: 10.1016/j.ophtha.2020.10.007.
3. Wu TT, Kung YH. Comparison of anatomical and visual outcomes of macular hole surgery in patients with high myopia vs. non-high myopia: a case-control study using optical coherence tomography[J]. Graefe's Arch Clin Exp Ophthalmol, 2012, 250(3): 327-331. DOI: 10.1007/s00417-011-1821-7.
4. Fernandes M, Sridhar MS, Sangwan VS, et al. Amniotic membrane transplantation for ocular surface reconstruction[J]. Cornea, 2005, 24(6): 643-653. DOI: 10.1097/01.ico.0000151501.80952.c5.
5. Kiilgaard JF, Scherfig E, Prause JU, et al. Transplantation of amniotic membrane to the subretinal space in pigs[J/OL]. Stem Cells Int, 2012, 2012: 716968[2021-03-05]. https://pubmed.ncbi.nlm.nih.gov/22550516/. DOI: 10.13039/501100005929.
6. Zhu D, Jin X, Zhou J. Transplantation of amniotic membrane for choroidal hole to treat suprachoroidal silicone oil migration[J/OL]. Acta Ophthalmol, 2017, 95(6): e522-e523[2017-07-11]. https://pubmed.ncbi.nlm.nih.gov/28696567/. DOI: 10.1111/aos.13516.
7. Caporossi T, Angelis L, Pacini B, et al. A human amniotic membrane plug to manage high myopic macular hole associated with retinal detachment[J/OL]. Acta Ophthalmol, 2020, 98(2): e252-e256[2019-07-18]. https://pubmed.ncbi.nlm.nih.gov/31318489/. DOI: 10.1111/aos.14174.
8. Takahashi H, Inoue M, Koto T, et al. Inverted internal limiting membrane flap technique for treatment of macular hole retinal detachment in highly myopic eyes[J]. Retina, 2018, 38(12): 2317-2326. DOI: 10.1097/IAE.0000000000001898.
9. Hangai M, Ojima Y, Gotoh N, et al. Three-dimensional imaging of macular holes with high-speed optical coherence tomography[J]. Ophthalmology, 2007, 114(4): 763-773. DOI: 10.1016/j.ophtha.2006.07.055.
10. Chen SN, Yang CM. Lens capsular flap transplantation in the management of refractory macular hole from multiple etiologies[J]. Retina, 2016, 36(1): 163-170. DOI: 10.1097/IAE.0000000000000674.
11. Lai CC, Chen YP, Wang NK, et al. Vitrectomy with internal limiting membrane repositioning and autologous blood for macular hole retinal detachment in highly myopic eyes[J]. Ophthalmology, 2015, 122(9): 1889-1898. DOI: 10.1016/j.ophtha.2015.05.040.
12. Grewal DS, Mahmoud TH. Autologous neurosensory retinal free flap for closure of refractory myopic macular holes[J]. JAMA Ophthalmol, 2016, 134(2): 229-230. DOI: 10.1001/jamaophthalmol.2015.5237.
13. Di Tizio F, Gattazzo I, Di Staso F, et al. Human amniotic membrane patch and platelet-rich plasma to promote retinal hole repair in a recurrent retinal detachment[J]. Eur J Ophthalmol, 2021, 31(3): 1479-1482. DOI: 10.1177/1120672120953314.
14. Moharram HM, Moustafa MT, Mortada HA, et al. Use of epimacular amniotic membrane graft in cases of recurrent retinal detachment due to failure of myopic macular hole closure[J]. Ophthalmic Surg Lasers Imaging Retina, 2020, 51(2): 101-108. DOI: 10.3928/23258160-20200129-06.

Chinese Journal of Ocular Fundus Diseases

The clinical effect of amniotic membrane patching in the treatment of recurrent macular hole associated with retinal detachment of high myopia

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