- Beijing Tongren Eye Center, Beijing Tongren Hospital, Beijing Ophthalmology and Visual Science Key Lab, Beijing Key Laboratory of Intraocular Tumor Diagnosis and Treatment, Capital Medical University, Beijing 100730, China;
Uveal melanoma (UM) is one of the most common primary intraocular malignancy in adults. The incidence of UM is lower in Asia than in Europe and the United States, however, the age of onset of UM patients in Asia is earlier than in the European and American populations. With the improvement of economic living standards in recent years, UM as a rare intraocular tumor has been gradually recognized by the public. In the past 10 years, the research of UM in China has been characterized by a large number and rapid development. Among them, the direction of molecular genetics represented by non-coding RNA, the frontier development of potential anticancer drugs for UM and Chinese traditional medicines are the research hotspots for scholars in China. In the past 10 years, China has made a relatively complete understanding and research progress on the pathogenesis, diagnosis and treatment of UM. On the other hand, compared with European and American countries, China still lacks in frontier research such as immunotherapy. With the further efforts of Chinese ophthalmology researchers and research teams, and with the further development of scientific research in my country, it is believed that the mechanism affecting tumors can be further elucidated, providing more possibilities for treatment and improving the prognosis of UM patients in China.
Citation: Liang Chuqiao, Luo Jingting, Li Yang, Wei Wenbin. Clinical research status and progress of uveal melanoma in China of 2011-2021. Chinese Journal of Ocular Fundus Diseases, 2022, 38(3): 242-247. doi: 10.3760/cma.j.cn511434-20220131-00062 Copy
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- 1. Shields CL, Kels JG, Shields JA. Melanoma of the eye: revealing hidden secrets, one at a time[J]. Clin Dermatol, 2015, 33(2): 183-196. DOI: 10.1016/j.clindermatol.2014.10.010.
- 2. Shields CL, Kaliki S, Shah SU, et al. Iris melanoma: features and prognosis in 317 children and adults[J]. J AAPOS, 2012, 16(1): 10-16. DOI: 10.1016/j.jaapos.2011.10.012.
- 3. Manchegowda P, Singh AD, Shields C, et al. Uveal melanoma in asians: a review[J]. Ocul Oncol Pathol, 2021, 7(3): 159-167. DOI: 10.1159/000512738.
- 4. Zhang H, Liu Y, Zhang K, et al. Validation of the relationship between iris color and uveal melanoma using artificial intelligence with multiple paths in a large chinese population[J/OL]. Front Cell Dev Biol, 2021, 9: 713209[2021-08-19]. https://pubmed.ncbi.nlm.nih.gov/34490264/. DOI: 10.3389/fcell.2021.713209.
- 5. Nayman T, Bostan C, Logan P, et al. Uveal melanoma risk factors: a systematic review of meta-analyses[J]. Curr Eye Res, 2017, 42(8): 1085-1093. DOI: 10.1080/02713683.2017.1297997.
- 6. Singh AD, De Potter P, Fijal BA, et al. Lifetime prevalence of uveal melanoma in white patients with oculo (dermal) melanocytosis[J]. Ophthalmology, 1998, 105(1): 195-198. DOI: 10.1016/s0161-6420(98)92205-9.
- 7. Zhou N, Zhang R, Liu Y, et al. Clinical characteristics of UM and association of metastasis of uveal melanoma with congenital oculocutaneous melanosis in Asian patients: analysis of 1 151 consecutive eyes[J]. Ophthalmol Retina, 2021, 5(11): 1164-1172. DOI: 10.1016/j.oret.2021.01.001.
- 8. Shi K, Bing ZT, Cao GQ, et al. Identify the signature genes for diagnose of uveal melanoma by weight gene co-expression network analysis[J]. Int J Ophthalmol, 2015, 8(2): 269-274. DOI: 10.3980/j.issn.2222-3959.2015.02.10.
- 9. Wang F, Wang Q, Li N, et al. OSuvm: an interactive online consensus survival tool for uveal melanoma prognosis analysis[J]. Mol Carcinog, 2020, 59(1): 56-61. DOI: 10.1002/mc.23128.
- 10. Zeng Q, Yao Y, Zhao M. Development and validation of a nomogram to predict cancer-specific survival of uveal melanoma[J]. BMC Ophthalmol, 2021, 21(1): 230. DOI: 10.1186/s12886-021-01968-6.
- 11. Hou C, Xiao L, Ren X, et al. Mutations of GNAQ, GNA11, SF3B1, EIF1AX, PLCB4 and CYSLTR in uveal melanoma in Chinese patients[J]. Ophthalmic Res, 2020, 63(3): 358-368. DOI: 10.1159/000502888.
- 12. 何继才, 杨荣琴, 彭睿. 四川地区脉络膜黑色素瘤患者GNAQ, GNA11基因突变检测[J]. 眼科学报, 2019, 34(2): 99-102. DOI: 10.3978/j.issn.1000-4432.2019.05.04.He JC, Yang RQ, Peng R. Genetic analyses of GNAQ and GNA11 mutation in uveal melanoma in Sichuan[J]. Eye Science, 2019, 34(2): 99-102. DOI: 10.3978/j.issn.1000-4432.2019.05.04.
- 13. Yu J, Wu X, Yan J, et al. Potential mutations in uveal melanoma identified using targeted next-generation sequencing[J]. J Cancer, 2019, 10(2): 488-493. DOI: 10.7150/jca.26967.
- 14. 李洋, 冯宇, 刘月明, 等. BAP1、FOXO3和ITPR2基因表达变化与葡萄膜黑色素瘤转移和预后关联分析[J]. 中华实验眼科杂志, 2021, 39(8): 700-707. DOI: 10.3760/cma.j.cn115989-20200714-00495.Li Y, Feng Y, Liu YM, et al. Relationship between BAP1, FOXO3 and ITPR2 gene expression and metastasis and prognosis of uveal melanoma[J]. Chin J Exp Ophthalmol, 2021, 39(8): 700-707. DOI: 10.3760/cma.j.cn115989-20200714-00495.
- 15. Chen Y, Lu X, Montoya-Durango DE, et al. ZEB1 regulates multiple oncogenic components involved in uveal melanoma progression[J/OL]. Sci Rep, 2017, 7(1): 45[2017-03-03]. https://pubmed.ncbi.nlm.nih.gov/28246385/. DOI: 10.1038/s41598-017-00079-x.
- 16. Wang Y, Bao X, Zhang Z, et al. FGF2 promotes metastasis of uveal melanoma cells via store-operated calcium entry[J]. Onco Targets Ther, 2017, 10: 5317-5328. DOI: 10.2147/OTT.S136677.
- 17. Hao L, Yin J, Yang H, et al. ALKBH5-mediated m(6)A demethylation of FOXM1 mRNA promotes progression of uveal melanoma[J]. Aging (Albany NY), 2021, 13(3): 4045-4062. DOI: 10.18632/aging.202371.
- 18. Ding X, Wang L, Chen M, et al. Sperm-specific glycolysis enzyme glyceraldehyde-3-phosphate dehydrogenase regulated by transcription factor SOX10 to promote uveal melanoma tumorigenesis[J/OL]. Front Cell Dev Biol, 2021, 9: 610683[2021-07-25]. https://pubmed.ncbi.nlm.nih.gov/34249897/. DOI: 10.3389/fcell.2021.610683.
- 19. Wang P, Yang X, Zhou N, et al. Identifying a potential key gene, TIMP1, associated with liver metastases of uveal melanoma by weight gene co-expression network analysis[J]. Onco Targets Ther, 2020, 13: 11923-11934. DOI: 10.2147/OTT.S280435.
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