Visual analysis of the research status of ischemic optic neuropathy in China in the past 20 years_Chinese Journal of Ocular Fundus Diseases

Authors：

Lin Jilu ,  Wang Ying , Jiao Wenxin , Zhou Zhiyi , Long Siyu

Eye Hospital China Academy of Chinese Medical Sciences, Beijing 100040, China;

Corresponding author：

Wang Ying, Email: wangyingtcm@163.com

Keywords：

Ischemic optic neuropathy; Visual analysis; Bibliometrics

DOI：

10.3760/cma.j.cn511434-20230420-00175

Video：

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Objective To gain an in-depth understanding of the research status, hotspots, and future development trends in the field of ischemic optic neuropathy (ION). Methods Using “ischemic optic neuropathy” as the subject heading or keyword to search for relevant literature in Chinese and English databases from January 1, 2000, to December 31, 2022. The bibliometrics method and software were applied to construct the visualization map of authors, institutions, keyword co-occurrence, outburst words, and keyword clustering. Results A total of 1 203 ION-related articles were included, 1 106 Chinese literature and 97 English literature were included; the number of published articles in this field has fluctuated and increased in the past 20 years, mainly Chinese literature and English literature have shown a low growth trend. Chinese literature involved a total of 2 171 authors, and English literature involved 368 Chinese authors. A core team represented by Wang Runsheng, Wei Shihui, Zhong Yong, and Wei Qiping was formed among the high-yielding authors. Chinese literature involved a total of 799 research institutions, and English literature covered 119 Chinese institutions. The Xian No.1 Hospital and Beijing Tongren Hospital Affiliated to Capital Medical University respectively ranked first in the number of Chinese and English literature published in this field; 121 and 23 high-frequency keywords in Chinese and English were identified. In addition to “ischemic optic neuropathy”, compound anisodine, visual field, vision, treatment, risk factors, pathogenesis, optic nerve and rAION also appeared more frequently. The Chinese literature obtained 13 emergent words, and the English literature keywords formed 11 clusters. From the perspective of research type, the Chinese and English literature in this field mainly focued on the clinical efficacy observation of nonarteriotic Anterior ischemic optic neuropathy (NAION). Conclusions In the past 20 years, clinical studies of ION in China have mainly focused on the treatment of NAION, risk factors, and the application of auxiliary examinations in disease diagnosis. The combination of drugs in treatment, the application of optical coherence tomography angiography, and the research on pathogenesis is still a future research trend in this field.

Citation： Lin Jilu, Wang Ying, Jiao Wenxin, Zhou Zhiyi, Long Siyu. Visual analysis of the research status of ischemic optic neuropathy in China in the past 20 years. Chinese Journal of Ocular Fundus Diseases, 2023, 39(11): 918-927. doi: 10.3760/cma.j.cn511434-20230420-00175 Copy

1.	中华医学会眼科学分会神经眼科学组. 我国非动脉炎性前部缺血性视神经病变诊断和治疗专家共识(2015年)[J]. 中华眼科杂志, 2015, 51(15): 323-326. DOI: 10.3760/cma.j.issn.0412-4081.2015.05.002.Neuro-ophthalmology Group, Ophthalmology Branch of Chinese Medical Association. Diagnosis and treatment guideline of nonarteritic anterior ischemic optic neuropathy in China(2015)[J]. Chin J Ophthalmol, 2015, 51(15): 323-326. DOI: 10.3760/cma.j.issn.0412-4081.2015.05.002.
2.	Hattenhauer MG, Leavitt JA, Hodge DO, et al. Incidence of nonarteritic anterior ischemic optic neuropathy[J]. Am J Ophthalmol, 1997, 123(1): 103-107. DOI: 10.1016/s0002-9394(14)70999-7.
3.	Biousse V, Newman NJ. Ischemic optic neuropathies[J]. N Engl J Med, 2015, 372(25): 2428-2436. DOI: 10.1056/NEJMra1413352.
4.	Morrow MJ. Ischemic optic neuropathy[J]. Continuum, 2019, 25(5): 1215-1235. DOI: 10.1212/CON.0000000000000767.
5.	Wang RS, Lv PL, Wang WJ, et al. Establishing an experimental model of photodynamically induced anterior ischemic optic neuropathy[J]. Vis Neurosci, 2011, 28(2): 155-162. DOI: 10.1017/S0952523810000398.
6.	王润生, 于彬科, 张玉磊, 等. 维替泊芬光动力疗法诱导大鼠前部缺血性视神经病变模型研究[J]. 中国激光医学杂志, 2009, 18(6): 341-344. DOI: 10.13480/j.issn1003-9430.2009.06.009.Wang RH, Yu BK, Zhang YL, et al. A rat model of anterior ischemic optic neuropathy induced by verteporfin and 689 nm laser[J]. Chin J Laser Med Surg, 2009, 18(6): 341-344. DOI: 10.13480/j.issn1003-9430.2009.06.009.
7.	王润生, 吕沛霖, 张玉磊, 等. 光动力诱导大鼠缺血性视神经病变血浆ET-1浓度变化及药物调控作用[J]. 中华眼科杂志, 2010, 46(12): 1079-1083. DOI: 10.3760/cma.j.issn.0412-4081.2010.12.007.Wang RH, Lyu PL, Zhang YL, et al. Change of plasma endothelin-1 concentrations in photodynamic induced rat anterior ischemic optic neuropathy model and drug modulation[J]. Chin J Ophthalmol, 2010, 46(12): 1079-1083. DOI: 10.3760/cma.j.issn.0412-4081.2010.12.007.
8.	Huang SP, Tsai RK. Efficacy of granulocyte-colony stimulating factor treatment in a rat model of anterior ischemic optic neuropathy[J]. Neural Regen Res, 2014, 9(16): 1502-1505. DOI: 10.4103/1673-5374.139472.
9.	Nguyen Ngo Le MA, Wen YT, Ho YC, et al. Therapeutic effects of puerarin against anterior ischemic optic neuropathy through antiapoptotic and anti-inflammatory actions[J]. Invest Ophthalmol Vis Sci, 2019, 60(10): 3481-3491. DOI: 10.1167/iovs.19-27129.
10.	Chen TW, Wu PY, Wen YT, et al. Vitamin B3 provides neuroprotection via antioxidative stress in a rat model of anterior ischemic optic neuropathy[J/OL]. Antioxidants (Basel), 2022, 11(12): 2422[2022-12-08]. https://pubmed.ncbi.nlm.nih.gov/36552630/. DOI: 10.3390/antiox11122422.
11.	Yu B, Li XR, Zhang XM. Mesenchymal stem cell-derived extracellular vesicles as a new therapeutic strategy for ocular diseases[J]. World J Stem Cells, 2020, 12(3): 178-187. DOI: 10.4252/wjsc.v12.i3.178.
12.	Li D, Gong Y. A promising strategy for non-arteritic anterior ischemic optic neuropathy: intravitreal mesenchymal stem cell exosome[J]. Curr Stem Cell Res Ther, 2021, 16(2): 109-114. DOI: 10.2174/1574888X15666200814121849.
13.	Cheng SZ, Xing CY, Zhang ZH. New research advances in the treatment of nonarteritic anterior ischemic optic neuropathy[J]. Int J Front Med, 2022, 4(10): 16-23. DOI: 10.25236/IJFM.2022.041004.
14.	Wen YT, Ho YC, Lee YC, et al. The benefits and hazards of intravitreal mesenchymal stem cell (msc) based-therapies in the experimental ischemic optic neuropathy[J/OL]. Int J Mol Sci, 2021, 22(4): 2117[2021-02-20]. https://pubmed.ncbi.nlm.nih.gov/33672743/. DOI: 10.3390/ijms22042117.
15.	郭嘉术, 张姝雅, 张晨曦, 等. 彩色多普勒超声在非动脉炎性前部缺血性视神经病变患者中的诊断价值[J]. 分子影像学杂志, 2021, 44(1): 63-67. DOI: 10.12122/j.issn.1674-4500.2021.01.13.Guo JS, Zhang SY, Zhang CX, et al. Clinical significance of CDFI in the detection of carotid artery and retro-ocular blood flow parameters in patients with NAION[J]. Journal of Molecular Imaging, 2021, 44(1): 63-67. DOI: 10.12122/j.issn.1674-4500.2021.01.13.
16.	胡立影, 李志清, 李筱荣, 等. 前部缺血性视神经病变患眼视盘血流灌注的光相干断层扫描血管成像观察[J]. 中华眼底病杂志, 2016, 32(3): 275-277. DOI: 10.3760/cma.j.issn.1005-1015.2016.03.011.Hu LY, Li ZQ, Li XR, et al. Optical coherence tomography angiography in anterior ischemic optic neuropathy[J]. Chin J Ocul Fundus Dis, 2016, 32(3): 275-277. DOI: 10.3760/cma.j.issn.1005-1015.2016.03.011.
17.	Pugazhendhi S, Yu M, Zhou G, et al. Peripapillary and macular microvasculature features of non-arteritic anterior ischemic optic neuropathy[J/OL]. Front Med (Lausanne), 2022, 9: 1033838[2023-01-12]. https://pubmed.ncbi.nlm.nih.gov/36714135/. DOI: 10.3389/fmed.2022.1033838.
18.	Bunod R, Lubrano M, Pirovano A, et al. A deep learning system using optical coherence tomography angiography to detect glaucoma and anterior ischemic optic neuropathy[J]. J Clin Med, 2023, 12(2): 507. DOI: 10.3390/jcm12020507.
19.	Fu Z, Li H, Wang Y. Implication of retrobulbar and internal carotid artery blood-flow-volume alterations for the pathogenesis of non-arteritic anterior ischemic optic neuropathy[J]. BMC Ophthalmol, 2021, 21(1): 309. DOI: 10.1186/s12886-021-02075-2.
20.	胡立影, 李志清, 邵先锋, 等. 大鼠非动脉炎性前部缺血性视神经病变模型视神经蛋白质组学分析[J]. 中华实验眼科杂志, 2022, 40(1): 13-20. DOI: 10.3760/cma.j.cn115989-20201104-00745.Hu LY, Li ZQ, Shao XF, et al. Proteomic analysis of optic nerve in the rat model non-arteritic anterior ischemic optic neuropathy[J]. Chin J Exp Ophthalmol, 2022, 40(1): 13-20. DOI: 10.3760/cma.j.cn115989-20201104-00745.
21.	Georgiou T, Wen YT, Chang CH, et al. Neuroprotective effects of omega-3 polyunsaturated fatty acids in a rat model of anterior ischemic optic neuropathy[J]. Invest Ophthalmol Vis Sci, 2017, 58(3): 1603-1611. DOI: 10.1167/iovs.16-20979.
22.	Li L, Su Y, Liu J, et al. Efficacy of vincamine treatment in a rat model of anterior ischemic optic neuropathy[J]. Eur J Ophthalmol, 2021, 31(6): 3442-3449. DOI: 10.1177/1120672120974283.
23.	王影, 郭辉, 赵子德, 等. 沿视觉传导通路电针疗法对前部缺血性视神经病变兔细胞凋亡干预的研究[J]. 中国针灸, 2017, 37(8): 857-862. DOI: 10.13703/j.0255-2930.2017.08.015.Wang Y, Guo H, Zhao ZD, et al. Study on electroacupuncture along the visual conductive pathway for ocular cell apoptosis in anterior ischemic optic neuropathy[J]. Chinese Acupuncture & Moxibustion, 2017, 37(8): 857-862. DOI: 10.13703/j.0255-2930.2017.08.015.
24.	田紫煜, 李淑敏, 郭辉, 等. 眶内及眶外针刺对兔眼非动脉炎性前部缺血性视神经病变细胞Bax/Bcl-2及半胱氨酸天冬氨酸蛋白酶3表达的影响[J]. 针刺研究, 2019, 44(4): 282-287. DOI: 10.13702/j.1000-0607.180440.Tian ZY, Li SM, Guo H, et al. Acupuncture of intraorbital and extraorbital acupoints reduces apoptosis of retinal ganglion by down-regulating expression of caspase-3 and ratio of Bax/Bcl-2 in rabbits with nonarteritis anterior ischemic optic neuropathy[J]. Acupuncture Research, 2019, 44(4): 282-287. DOI: 10.13702/j.1000-0607.180440.
25.	Wang Y, Brown DP, Duan Y, et al. A novel rodent model of posterior ischemic optic neuropathy[J]. JAMA Ophthalmol, 2013, 131(2): 194-204. DOI: 10.1001/2013.jamaophthalmol.271.

1. 中华医学会眼科学分会神经眼科学组. 我国非动脉炎性前部缺血性视神经病变诊断和治疗专家共识(2015年)[J]. 中华眼科杂志, 2015, 51(15): 323-326. DOI: 10.3760/cma.j.issn.0412-4081.2015.05.002.Neuro-ophthalmology Group, Ophthalmology Branch of Chinese Medical Association. Diagnosis and treatment guideline of nonarteritic anterior ischemic optic neuropathy in China(2015)[J]. Chin J Ophthalmol, 2015, 51(15): 323-326. DOI: 10.3760/cma.j.issn.0412-4081.2015.05.002.
2. Hattenhauer MG, Leavitt JA, Hodge DO, et al. Incidence of nonarteritic anterior ischemic optic neuropathy[J]. Am J Ophthalmol, 1997, 123(1): 103-107. DOI: 10.1016/s0002-9394(14)70999-7.
3. Biousse V, Newman NJ. Ischemic optic neuropathies[J]. N Engl J Med, 2015, 372(25): 2428-2436. DOI: 10.1056/NEJMra1413352.
4. Morrow MJ. Ischemic optic neuropathy[J]. Continuum, 2019, 25(5): 1215-1235. DOI: 10.1212/CON.0000000000000767.
5. Wang RS, Lv PL, Wang WJ, et al. Establishing an experimental model of photodynamically induced anterior ischemic optic neuropathy[J]. Vis Neurosci, 2011, 28(2): 155-162. DOI: 10.1017/S0952523810000398.
6. 王润生, 于彬科, 张玉磊, 等. 维替泊芬光动力疗法诱导大鼠前部缺血性视神经病变模型研究[J]. 中国激光医学杂志, 2009, 18(6): 341-344. DOI: 10.13480/j.issn1003-9430.2009.06.009.Wang RH, Yu BK, Zhang YL, et al. A rat model of anterior ischemic optic neuropathy induced by verteporfin and 689 nm laser[J]. Chin J Laser Med Surg, 2009, 18(6): 341-344. DOI: 10.13480/j.issn1003-9430.2009.06.009.
7. 王润生, 吕沛霖, 张玉磊, 等. 光动力诱导大鼠缺血性视神经病变血浆ET-1浓度变化及药物调控作用[J]. 中华眼科杂志, 2010, 46(12): 1079-1083. DOI: 10.3760/cma.j.issn.0412-4081.2010.12.007.Wang RH, Lyu PL, Zhang YL, et al. Change of plasma endothelin-1 concentrations in photodynamic induced rat anterior ischemic optic neuropathy model and drug modulation[J]. Chin J Ophthalmol, 2010, 46(12): 1079-1083. DOI: 10.3760/cma.j.issn.0412-4081.2010.12.007.
8. Huang SP, Tsai RK. Efficacy of granulocyte-colony stimulating factor treatment in a rat model of anterior ischemic optic neuropathy[J]. Neural Regen Res, 2014, 9(16): 1502-1505. DOI: 10.4103/1673-5374.139472.
9. Nguyen Ngo Le MA, Wen YT, Ho YC, et al. Therapeutic effects of puerarin against anterior ischemic optic neuropathy through antiapoptotic and anti-inflammatory actions[J]. Invest Ophthalmol Vis Sci, 2019, 60(10): 3481-3491. DOI: 10.1167/iovs.19-27129.
10. Chen TW, Wu PY, Wen YT, et al. Vitamin B3 provides neuroprotection via antioxidative stress in a rat model of anterior ischemic optic neuropathy[J/OL]. Antioxidants (Basel), 2022, 11(12): 2422[2022-12-08]. https://pubmed.ncbi.nlm.nih.gov/36552630/. DOI: 10.3390/antiox11122422.
11. Yu B, Li XR, Zhang XM. Mesenchymal stem cell-derived extracellular vesicles as a new therapeutic strategy for ocular diseases[J]. World J Stem Cells, 2020, 12(3): 178-187. DOI: 10.4252/wjsc.v12.i3.178.
12. Li D, Gong Y. A promising strategy for non-arteritic anterior ischemic optic neuropathy: intravitreal mesenchymal stem cell exosome[J]. Curr Stem Cell Res Ther, 2021, 16(2): 109-114. DOI: 10.2174/1574888X15666200814121849.
13. Cheng SZ, Xing CY, Zhang ZH. New research advances in the treatment of nonarteritic anterior ischemic optic neuropathy[J]. Int J Front Med, 2022, 4(10): 16-23. DOI: 10.25236/IJFM.2022.041004.
14. Wen YT, Ho YC, Lee YC, et al. The benefits and hazards of intravitreal mesenchymal stem cell (msc) based-therapies in the experimental ischemic optic neuropathy[J/OL]. Int J Mol Sci, 2021, 22(4): 2117[2021-02-20]. https://pubmed.ncbi.nlm.nih.gov/33672743/. DOI: 10.3390/ijms22042117.
15. 郭嘉术, 张姝雅, 张晨曦, 等. 彩色多普勒超声在非动脉炎性前部缺血性视神经病变患者中的诊断价值[J]. 分子影像学杂志, 2021, 44(1): 63-67. DOI: 10.12122/j.issn.1674-4500.2021.01.13.Guo JS, Zhang SY, Zhang CX, et al. Clinical significance of CDFI in the detection of carotid artery and retro-ocular blood flow parameters in patients with NAION[J]. Journal of Molecular Imaging, 2021, 44(1): 63-67. DOI: 10.12122/j.issn.1674-4500.2021.01.13.
16. 胡立影, 李志清, 李筱荣, 等. 前部缺血性视神经病变患眼视盘血流灌注的光相干断层扫描血管成像观察[J]. 中华眼底病杂志, 2016, 32(3): 275-277. DOI: 10.3760/cma.j.issn.1005-1015.2016.03.011.Hu LY, Li ZQ, Li XR, et al. Optical coherence tomography angiography in anterior ischemic optic neuropathy[J]. Chin J Ocul Fundus Dis, 2016, 32(3): 275-277. DOI: 10.3760/cma.j.issn.1005-1015.2016.03.011.
17. Pugazhendhi S, Yu M, Zhou G, et al. Peripapillary and macular microvasculature features of non-arteritic anterior ischemic optic neuropathy[J/OL]. Front Med (Lausanne), 2022, 9: 1033838[2023-01-12]. https://pubmed.ncbi.nlm.nih.gov/36714135/. DOI: 10.3389/fmed.2022.1033838.
18. Bunod R, Lubrano M, Pirovano A, et al. A deep learning system using optical coherence tomography angiography to detect glaucoma and anterior ischemic optic neuropathy[J]. J Clin Med, 2023, 12(2): 507. DOI: 10.3390/jcm12020507.
19. Fu Z, Li H, Wang Y. Implication of retrobulbar and internal carotid artery blood-flow-volume alterations for the pathogenesis of non-arteritic anterior ischemic optic neuropathy[J]. BMC Ophthalmol, 2021, 21(1): 309. DOI: 10.1186/s12886-021-02075-2.
20. 胡立影, 李志清, 邵先锋, 等. 大鼠非动脉炎性前部缺血性视神经病变模型视神经蛋白质组学分析[J]. 中华实验眼科杂志, 2022, 40(1): 13-20. DOI: 10.3760/cma.j.cn115989-20201104-00745.Hu LY, Li ZQ, Shao XF, et al. Proteomic analysis of optic nerve in the rat model non-arteritic anterior ischemic optic neuropathy[J]. Chin J Exp Ophthalmol, 2022, 40(1): 13-20. DOI: 10.3760/cma.j.cn115989-20201104-00745.
21. Georgiou T, Wen YT, Chang CH, et al. Neuroprotective effects of omega-3 polyunsaturated fatty acids in a rat model of anterior ischemic optic neuropathy[J]. Invest Ophthalmol Vis Sci, 2017, 58(3): 1603-1611. DOI: 10.1167/iovs.16-20979.
22. Li L, Su Y, Liu J, et al. Efficacy of vincamine treatment in a rat model of anterior ischemic optic neuropathy[J]. Eur J Ophthalmol, 2021, 31(6): 3442-3449. DOI: 10.1177/1120672120974283.
23. 王影, 郭辉, 赵子德, 等. 沿视觉传导通路电针疗法对前部缺血性视神经病变兔细胞凋亡干预的研究[J]. 中国针灸, 2017, 37(8): 857-862. DOI: 10.13703/j.0255-2930.2017.08.015.Wang Y, Guo H, Zhao ZD, et al. Study on electroacupuncture along the visual conductive pathway for ocular cell apoptosis in anterior ischemic optic neuropathy[J]. Chinese Acupuncture & Moxibustion, 2017, 37(8): 857-862. DOI: 10.13703/j.0255-2930.2017.08.015.
24. 田紫煜, 李淑敏, 郭辉, 等. 眶内及眶外针刺对兔眼非动脉炎性前部缺血性视神经病变细胞Bax/Bcl-2及半胱氨酸天冬氨酸蛋白酶3表达的影响[J]. 针刺研究, 2019, 44(4): 282-287. DOI: 10.13702/j.1000-0607.180440.Tian ZY, Li SM, Guo H, et al. Acupuncture of intraorbital and extraorbital acupoints reduces apoptosis of retinal ganglion by down-regulating expression of caspase-3 and ratio of Bax/Bcl-2 in rabbits with nonarteritis anterior ischemic optic neuropathy[J]. Acupuncture Research, 2019, 44(4): 282-287. DOI: 10.13702/j.1000-0607.180440.
25. Wang Y, Brown DP, Duan Y, et al. A novel rodent model of posterior ischemic optic neuropathy[J]. JAMA Ophthalmol, 2013, 131(2): 194-204. DOI: 10.1001/2013.jamaophthalmol.271.

Chinese Journal of Ocular Fundus Diseases

Visual analysis of the research status of ischemic optic neuropathy in China in the past 20 years

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