Research progress on cellular senescence and senescence-associated secretory phenotype in pathogenesis and treatment of age-related macular degeneration_Chinese Journal of Ocular Fundus Diseases

Authors：

Li Yuchen ¹ , Xu Yidan ² , Zhao Feng ² ,  Chen Lixun ²

1. Third Clinical Medical School, Nanjing Medical University, Nanjing 211166, China;
2. Department of Ophthalmology, Nanjing First Hospital, Nanjing 210006, China;

Corresponding author：

Chen Lixun, Email: lixunchen@hotmail.com

Keywords：

Age-related macular degeneration; Senescence; Oxidative stress; Inflammation; Review

DOI：

10.3760/cma.j.cn511434-20230508-00208

Video：

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Abstract Full text Figures/Tables Video References Cited by

Age-related macular degeneration (AMD) is one of the leading irreversible causes of blindness in China. The pathogenesis of AMD is not fully understood at present. Under various stress conditions, cellular senescence is activated, characterized by telomere shortening, mitochondrial dysfunction, DNA damage, and the release of various senescence-related secretory phenotype factors. Senescence is implicated in the pathogenesis of AMD through multiple pathways, contributing to chronic inflammation and the onset and progression of AMD. Mechanisms such as oxidative stress, lipofuscin, β amyloid protein and the membrane attack complex have become hotspots of study in the pathogenesis of AMD. The cyclic guanosine phosphate - adenosine synthase - interferon stimulating factor synthase-stimulator of interferon gene pathway has emerged as a critical signaling pathway in the early development of AMD, providing direction for further research on AMD. Currently, senolytics, selective agents targeting the induction of senescent cell apoptosis, show significant potential in the treatment of AMD. The integration of new technologies with cellular senescence may offer a novel approach to AMD treatment, and intervening in the AMD treatment through anti-cellular senescence pathways holds promising prospects.

Citation： Li Yuchen, Xu Yidan, Zhao Feng, Chen Lixun. Research progress on cellular senescence and senescence-associated secretory phenotype in pathogenesis and treatment of age-related macular degeneration. Chinese Journal of Ocular Fundus Diseases, 2024, 40(3): 233-238. doi: 10.3760/cma.j.cn511434-20230508-00208 Copy

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