Research progress on the bidirectional effect of autophagy on retinal neurovascular unit cells in diabetic retinopathy_Chinese Journal of Ocular Fundus Diseases

Authors：

Zhuang Jiayuan ¹ ,  Luo Xiangxia ² , Zheng Wanrui ¹ , Ma Xiaohua ¹

1. Clinical College of Traditional Chinese Medicine, Gansu University of Traditional Chinese Medicine, Lanzhou 750000, China;
2. Department of Ophthalmology, Gansu Provincial Hospital of Traditional Chinese Medicine, Lanzhou 730050, China;

Corresponding author：

Luo Xiangxia, Email: jessica_lxx@163.com

Keywords：

Diabetic retinopathy; Neurovascular unit; Autophagy; Bidirectional action; Review

DOI：

10.3760/cma.j.cn511434-20230512-00213

Video：

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Abstract Full text Figures/Tables Video References Cited by

Diabetes retinopathy (DR) is a blinding ocular complication of diabetes, and its pathological mechanism is complex. The damage to the retinal neurovascular unit (NVU) and the imbalance of its coupling mechanism are important pathological foundations. Autophagy plays an important role in the progression of DR. Oxidative stress, endoplasmic reticulum stress, hypoxia, and competitive endogenous RNA regulatory networks can affect the occurrence of autophagy, and autophagy induced cell death is crucial in NVU dysfunction. Retinal neurocyte are non- renewable cells, and adaptive autophagy targeting neuronal cells may provide a new direction for early vision rescue in patients with DR. It is necessary that exploring the possible autophagy interrelationships between ganglion cells, glial cells, and vascular constituent cells, searching for targeted specific cell autophagy inhibitors or activators, and exploring the impact of autophagy on the NVU complex more comprehensively at the overall level. Adopting different autophagy intervention methods at different stages of DR may be one promising research directions for future DR.

Citation： Zhuang Jiayuan, Luo Xiangxia, Zheng Wanrui, Ma Xiaohua. Research progress on the bidirectional effect of autophagy on retinal neurovascular unit cells in diabetic retinopathy. Chinese Journal of Ocular Fundus Diseases, 2024, 40(2): 159-164. doi: 10.3760/cma.j.cn511434-20230512-00213 Copy

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3. 中华医学会眼科学分会眼底病学组, 中国医师协会眼科医师分会眼底病学组. 我国糖尿病视网膜病变临床诊疗指南(2022年)[J]. 中华眼底病杂志, 2023, 39(2): 99-124. DOI: 10.3760/cma.j.cn511434-20230110-00018.Fundus Pathology Group, Ophthalmology Branch, Chinese Medical Association, Ophthalmology Branch, Chinese Medical Doctor Association. Evidence-based guidelines for diagnosis and treatment of diabetic retinopathy in China (2022)[J]. Chin J Ocul Fundus Dis, 2023, 39(2): 99-124. DOI: 10.3760/cma.j.cn511434-20230110-00018.
4. Kugler EC, Greenwood J, MacDonald RB. The "neuro-glial-vascular" unit: the role of glia in neurovascular unit formation and dysfunction[J/OL]. Front Cell Dev Biol, 2021, 9: 732820[2021-09-27]. https://pubmed.ncbi.nlm.nih.gov/34646826/. DOI: 10.3389/fcell.2021.732820.
5. 惠延年. 神经血管单元与糖尿病视网膜病变[J]. 国际眼科杂志, 2023, 23(3): 353-355. DOI: 10.3980/j.issn.1672-5123.2023.3.01.Hui YN. Neurovascular unit and diabetic retinopathy[J]. Int Eye Sci, 2023, 23(3): 353-355. DOI: 10.3980/j.issn.1672-5123.2023.3.01.
6. 李宝花, 郭超红, 郭承伟. 基于视网膜神经血管单元损伤及其耦联失衡防治糖尿病视网膜病变的研究进展[J]. 国际眼科杂志, 2022, 22(8): 1309-1312. DOI: 10.3980/j.issn.1672-5123.2022.8.14.Li BH, Guo CH, Guo CW. Research progress in prevention and treatment of diabetes retinopathy based on retinal neurovascular unit damage and its coupling imbalance[J]. Int Eye Sci, 2022, 22(8): 1309-1312. DOI: 10.3980/j.issn.1672-5123.2022.8.14.
7. 马雪菲, 匡洪宇. 从神经血管单元角度认识糖尿病视网膜病变[J]. 中华糖尿病杂志, 2019, 11(10): 641-644. DOI: 10.3760/cma.j.issn.1674-5809.2019.10.001.Ma XF, Kuang HY. Understanding diabetes retinopathy from the perspective of neurovascular unit[J]. Chin J of Diabetes Mellitus, 2019, 11(10): 641-644. DOI: 10.3760/cma.j.issn.1674-5809.2019.10.001.
8. Mathew B, Chennakesavalu M, Sharma M, et al. Autophagy and post-ischemic conditioning in retinal ischemia[J]. Autophagy, 2021, 17(6): 1479-1499. DOI: 10.1080/15548627.2020.1767371.
9. Klionsky DJ, Petroni G, Amaravadi RK, et al. Autophagy in major human diseases[J/OL]. EMBO J, 2021, 40(19): e108863[2021-08-30]. https://pubmed.ncbi.nlm.nih.gov/34459017/. DOI: 10.15252/embj.2021108863.
10. Rossino MG, Dal Monte M, Casini G. Relationships between neurodegeneration and vascular damage in diabetic retinopathy[J/OL]. Front Neuro sci, 2019, 13: 1172[2019-11-08]. https://pubmed.ncbi.nlm.nih.gov/31787868/. DOI: 10.3389/fnins.2019.01172.
11. Yang S, Zhang J, Chen L. The cells involved in the pathological process of diabetic retinopathy[J/OL]. Biomed Pharmacother, 2020, 132: 110818[2020-10-11]. https://pubmed.ncbi.nlm.nih.gov/33053509/. DOI: 10.1016/j.biopha.2020.110818.
12. Fu D, Yu JY, Yang S, et al. Survival or death: a dual role for autophagy in stress-induced pericyte loss in diabetic retinopathy[J]. Diabetologia, 2016, 59(10): 2251-2261. DOI: 10.1007/s00125-016-4058-5.
13. Rosa MD, Distefano G, Gagliano C, et al. Autophagy in diabetic retinopathy[J]. Curr Neuropharmacol, 2016, 14(8): 810-825. DOI: 10.2174/1570159x14666160321122900.
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Chinese Journal of Ocular Fundus Diseases

Research progress on the bidirectional effect of autophagy on retinal neurovascular unit cells in diabetic retinopathy

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