Construction of fundus disease-specific biobank: an evidence-based analysis and inspiration_Chinese Journal of Ocular Fundus Diseases

Authors：

Gu Qiumei ^1,2 , Chen Zhengju ³ ,  Lu Fang ¹

1. Department of Ophthalmology, West China Hospital, Sichuan University, Chengdu 610041, China;
2. Department of Biobank, West China Hospital, Sichuan University, Chengdu 610041, China;
3. Science and Technology Department, West China Hospital, Sichuan University, Chengdu 610041, China;

Corresponding author：

Lu Fang, Email: lufang@wchscu.cn

Keywords：

Biobanks; Disease-specific biobank; Fundus disease; Evidence-based medicine

DOI：

10.3760/cma.j.cn511434-20231110-00449

Video：

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Abstract Full text Figures/Tables Video References Cited by

Objective To explore the necessity, construction plans, and implementation methods for the establishment of a fundus disease-specific biobank are discussed. Methods An evidence-based medicine study. “Biobank”, “Disease-specific biobank”, “Eye diseases”, “Fundus disease” were hereby used as search terms. Literatures were retrieved related to biobank construction from PubMed, Embase, China National Knowledge Infrastructure, and Wanfang databases since their establishment until October 2023. Two researchers independently selected and analyzed literature, extracting data for further analysis. Results After screening, 23 articles were included, comprising 11 articles in Chinese and 12 articles in English, involving 23 institutions. The disease-specific biobank has been built earlier abroad than domestically. Both domestic and foreign biobank have a scale of less than 1, 1 to 10, and more than 10 thousand samples, with the eye disease-specific biobank having less than 10 thousand samples. The majority of these disease-specific biobank focued on tumor-related diseases and consist of both physical and information components. Ethical committees were required to declare and record the construction of biobank, and dedicated personnel and information management systems are established. Quality control systems have been developed with standard operating procedures from sample collection to storage. These disease-specific biobank effectively supported research projects, but there was a lack of resource sharing domestically compared to abroad. Based on practical experience, the construction of fundus disease-specific biobank at West China Hospital of Sichuan University has been improved. Separate sample collection processes have been formulated for outpatient clinics and operating rooms. Standard operating procedures have been established for unique eye samples, including vitreous fluid, proliferative membranes of the retina, aqueous humor, tears, etc., to ensure sample quality. Conclusion Establishing a fundus disease-specific biobank can promote basic and clinical research, advance the development of translational medicine, achieve resource sharing, and foster discipline development.

Citation： Gu Qiumei, Chen Zhengju, Lu Fang. Construction of fundus disease-specific biobank: an evidence-based analysis and inspiration. Chinese Journal of Ocular Fundus Diseases, 2024, 40(3): 215-221. doi: 10.3760/cma.j.cn511434-20231110-00449 Copy

1.	崔芳, 王潇雨, 谢文博. 规范诊疗眼底全力护航眼健康[N]. 健康报, 2022-03-11(3).Cui F, Wang XY, Xie WB, et al. Standardize the diagnosis and treatment of fundus with all-out efforts to protect eye health[N]. Health News, 2022-03-11(3).
2.	蔡晗, 刘丽媛, 王斐, 等. 中国乳腺癌专病队列研究: 泛共享生物样本库的建设与进展[J]. 中华流行病学杂志, 2020, 41(12): 2053-2058. DOI: 10.3760/cma.j.cn112338-20200507-00697.Cai H, Liu LY, Wang F, et al. The breast cancer cohort study in chinese women: the construction and progress of the pan-shared biobank[J]. Chin J Epidemiol, 2020, 41(12): 2053-2058. DOI: 10.3760/cma.j.cn112338-20200507-00697.
3.	Martel A, Gastaud L, Bonnetaud C, et al. Need for a dedicated ophthalmic malignancy clinico-biological biobank: the nice ocular malignancy (NOMA) biobank[J/OL]. Cancers (Basel), 2023, 15(8): 2372[2023-04-19]. https://pubmed.ncbi.nlm.nih.gov/37190299/. DOI: 10.3390/cancers15082372.
4.	Gangadharan C, Wills S, Vangala RK, et al. Biobanking for translational diabetes research in India[J]. Biores Open Access, 2020, 9(1): 183-189. DOI: 10.1089/biores.2019.0052.
5.	Lacerda EM, Mudie K, Kingdon CC, et al. The UK ME/CFS Biobank: a disease-specific biobank for advancing clinical research into myalgic encephalomyelitis/chronic fatigue syndrome[J/OL]. Front Neurol, 2018, 9: 1026[2018-12-04]. https://pubmed.ncbi.nlm.nih.gov/30564186/. DOI: 10.3389/fneur.2018.01026.
6.	Bourgeois FT, Avillach P, Kong SW, et al. Development of the precision link biobank at Boston children's hospital: challenges and opportunities[J]. J Pers Med, 2017, 7(4): 21. DOI: 10.3390/jpm7040021.
7.	Lal S, Li A, Allen D, et al. Best practice biobanking of human heart tissue[J]. Biophys Rev, 2015, 7(4): 399-406. DOI: 10.1007/s12551-015-0182-6.
8.	Cervo S, De Paoli P, Perin T, et al. Cost-effective organization of an institutional human cancer biobank in a clinical setting: CRO-Biobank experience toward harmonization[J/OL]. Int J Biol Markers, 2015, 30(2): e243-e251[2015-05-26]. https://pubmed.ncbi.nlm.nih.gov/25744364/. DOI: 10.5301/jbm.5000138.
9.	Skeie JM, Tsang SH, Zande RV, et al. A biorepository for ophthalmic surgical specimens[J]. Proteomics Clin Appl, 2014, 8(3-4): 209-217. DOI: 10.1002/prca.201300043.
10.	Reis ST, Feitosa EB, Pontes-Junior J, et al. Tumor banks: the cornerstone of basic research in urology[J]. Int Braz J Urol, 2010, 36(3): 348-354. DOI: 10.1590/s1677-55382010000300012.
11.	张赛, 吴静, 周佳宜, 等. 妇产科专科生物样本库3.0版本的建立与管理[J]. 复旦学报(医学版), 2023, 50(3): 456-461. DOI: 10.3969/j.issn.1672-8467.2023.03.019.Zhang S, Wu J, Zhou JY, et al. Establishment and management of obstetric and gynecologic biobank 3.0[J]. Fudan Univ J Med Sci, 2023, 50(3): 456-461. DOI: 10.3969/j.issn.1672-8467.2023.03.019.
12.	张欣冉, 张梅, 李艳英, 等. 矮小症生物样本库建立与管理[J]. 中国医药生物技术, 2023, 18(2): 162-164. DOI: 10.3969/j.issn.1673-713X.2023.02.012.Zhang XR, Zhang M, Li YY, et al. Establishment and management of a biobank for dwarfism[J]. Chin Med Biotechnol, 2023, 18(2): 162-164. DOI: 10.3969/j.issn.1673-713X.2023.02.012.
13.	郭艺博, 刘怡文, 杨海军, 等. 高发区食管癌生物样本库的建立与管理[J]. 食管疾病, 2022, 4(1): 55-58. DOI: 10.15926/j.cnki.issn2096-7381.2022.01.014.Guo YB, Liu YW, Yang HJ, et al. Establishment and management of esophageal cancer biobank in high incidence area[J]. Journal of Esophageal Diseases, 2022, 4(1): 55-58. DOI: 10.15926/j.cnki.issn2096-7381.2022.01.014.
14.	秦玲莎, 王欢, 张恬, 等. 地市级医院建设脑血管病专病生物样本库的可行性探讨[J]. 中国标准化, 2022, 11(22): 239-242. DOI: 10.3969/j.issn.1002-5944.2022.22.049.Qin LS, Wang H, Zhag T, et al. Discussion on the feasibility of constructing biobank for cerebrovascular diseases in prefecture-level hospitals[J]. China Standardization, 2022, 11(22): 239-242. DOI: 10.3969/j.issn.1002-5944.2022.22.049.
15.	喻晶晶, 肖巍, 李娅妮, 等. 肝癌生物样本库的标准化建立与信息化管理[J]. 临床肝胆病杂志, 2022, 38(5): 1092-1096. DOI: 10.3969/j.issn.1001-5256.2022.05.022.Yu JJ, Xiao W, Li YN, et al. Standardized establishment and informationized management of liver cancer biobank[J]. J Chin Hepatol, 2022, 38(5): 1092-1096. DOI: 10.3969/j.issn.1001-5256.2022.05.022.
16.	林金嬉, 梁宪红, 李上智, 等. 中国脑血管病多中心临床研究生物样本库建设模式探讨[J]. 中国卒中杂志, 2021, 16(6): 567-573. DOI: 10.3969/j.issn.1673-5765.2021.06.007.Lin JX, Liang XH, Li SZ, et al. Exploring the construction model of multi-center clinical research biobank for cerebrovascular disease in China[J]. Chin J Stroke, 2021, 16(6): 567-573. DOI: 10.3969/j.issn.1673-5765.2021.06.007.
17.	张林, 姚品芳, 刘媛媛, 等. 湖北省肿瘤医院3.0版肿瘤生物样本库的建立与管理[J]. 中国肿瘤, 2021, 30(1): 48-53. DOI: 10.11735/j.issn.1004-0242.2021.01.A005.Zhang L, Yao PF, Liu YY, et al. Establishment and management of tumor biobank 3.0 in Hubei Cancer Hospital[J]. China Cancer, 2021, 30(1): 48-53. DOI: 10.11735/j.issn.1004-0242.2021.01. A005. DOI: 10.11735/j.issn.1004-0242.2021.01.A005.
18.	宋金云, 赵宏宇. 不明原因肝病生物样本库的建立与管理[J]. 肝脏, 2021, 26(2): 199-201. DOI: 10.3969/j.issn.1008-1704.2021.02.027.Song JY, Zhao HY. Establishment and management of biobank for unknown etiology liver disease[J]. Chinese Hepatology, 2021, 26(2): 199-201. DOI: 10.3969/j.issn.1008-1704.2021.02.027.
19.	Gao Z, Tan J, Wang S, et al. The xiangya ocular tumor bank: a disease-specific biobank for advancing translational research into ocular tumors[J/OL]. Front Med (Lausanne), 2022, 8: 774624[2022-01-27]. https://pubmed.ncbi.nlm.nih.gov/35155464/. DOI: 10.3389/fmed.2021.774624.
20.	Yang P, Du L, Ye Z. How to deal with uveitis patients?[J]. Curr Mol Med, 2018, 17(7): 468-470. DOI: 10.2174/15665240186661 80207153342.
21.	郑雪妮, 段小红. 口腔罕见病与遗传病生物样本库的建立与完善[J]. 实用口腔医学杂志, 2016, 32(6): 773-777. DOI: 10.3969/j.issn.1001-3733.2016.06.006.Zheng XN, Duan XH. Developmentofa biobank oforalraredisessesand geneticdiseases[J]. J Pract Stomatol, 2016, 32(6): 773-777. DOI: 10.3969/j.issn.1001-3733.2016.06.006.
22.	王敏, 高志梅, 吕志宝, 等. 儿童专科医院特色生物样本库的建立与应用[J]. 中国医药生物技术, 2016, 11(3): 280-284. DOI: 10.3969/j.issn.1673-713X.2016.03.017.Wang M, Gao ZM, Lyu ZB, et al. Establishment and application of a characteristic biobank in children's specialized hospitals[J]. Chin Med Biotechnol, 2016, 11(3): 280-284. DOI: 10.3969/j.issn.1673-713X.2016.03.017.
23.	Yang Y, Liu YM, Wei MY, et al. The liver tissue bank and clinical database in China[J]. Front Med China, 2010, 4(4): 443-447. DOI: 10.1007/s11684-010-0190-7.
24.	Li H, Qiu Y, Zhang X, et al. Establishment of a lung cancer biobank of a southern chinese population[J]. J Thorac Dis, 2009, 1(1): 17-22.
25.	丁玲, 丁斐, 王钊, 等. 生物样本库行业管理规范[M]//陈曲波. 生物样本库信息系统功能设计与实践. 北京: 人民卫生出版社, 2022: 1-10.Ding L, Ding F, Wang Z, et al. Biobank industry management standard[M]//Chen QB. Functional design and practice of biobank information system. Beijing: People's Health Publishing House, 2022: 1-10.
26.	国家卫生健康委关于印发“十四五”全国眼健康规划(2021-2025年)的通知. 国卫医发〔2022〕1号. 2022-01-04. https://www.gov.cn/zhengce/zhengceku/2022-01/17/content_5668951.htm.Circular of the National Health Commission on the issuance of the National Eye Health Plan for the 14th Five-Year Plan (2021-2025). National Health and Medical Development [2022] No. 1. 2022-01-04. https://www.gov.cn/zhengce/zhengceku/2022-01/17/content_5668951.htm.
27.	王乐, 刘苏来, 蒋宇, 等. 肿瘤生物样本库的发展现状及探讨[J]. 现代肿瘤医学, 2020, 28(5): 832-835. DOI: 10.3969/j.issn.1672-4992.2020.05.033.Wang L, Liu SL, Jiang Y, et al. Development status and discussion of biobank[J]. Modern Oncology, 2020, 28(5): 832-835. DOI: 10.3969/j.issn.1672-4992.2020.05.033.

1. 崔芳, 王潇雨, 谢文博. 规范诊疗眼底全力护航眼健康[N]. 健康报, 2022-03-11(3).Cui F, Wang XY, Xie WB, et al. Standardize the diagnosis and treatment of fundus with all-out efforts to protect eye health[N]. Health News, 2022-03-11(3).
2. 蔡晗, 刘丽媛, 王斐, 等. 中国乳腺癌专病队列研究: 泛共享生物样本库的建设与进展[J]. 中华流行病学杂志, 2020, 41(12): 2053-2058. DOI: 10.3760/cma.j.cn112338-20200507-00697.Cai H, Liu LY, Wang F, et al. The breast cancer cohort study in chinese women: the construction and progress of the pan-shared biobank[J]. Chin J Epidemiol, 2020, 41(12): 2053-2058. DOI: 10.3760/cma.j.cn112338-20200507-00697.
3. Martel A, Gastaud L, Bonnetaud C, et al. Need for a dedicated ophthalmic malignancy clinico-biological biobank: the nice ocular malignancy (NOMA) biobank[J/OL]. Cancers (Basel), 2023, 15(8): 2372[2023-04-19]. https://pubmed.ncbi.nlm.nih.gov/37190299/. DOI: 10.3390/cancers15082372.
4. Gangadharan C, Wills S, Vangala RK, et al. Biobanking for translational diabetes research in India[J]. Biores Open Access, 2020, 9(1): 183-189. DOI: 10.1089/biores.2019.0052.
5. Lacerda EM, Mudie K, Kingdon CC, et al. The UK ME/CFS Biobank: a disease-specific biobank for advancing clinical research into myalgic encephalomyelitis/chronic fatigue syndrome[J/OL]. Front Neurol, 2018, 9: 1026[2018-12-04]. https://pubmed.ncbi.nlm.nih.gov/30564186/. DOI: 10.3389/fneur.2018.01026.
6. Bourgeois FT, Avillach P, Kong SW, et al. Development of the precision link biobank at Boston children's hospital: challenges and opportunities[J]. J Pers Med, 2017, 7(4): 21. DOI: 10.3390/jpm7040021.
7. Lal S, Li A, Allen D, et al. Best practice biobanking of human heart tissue[J]. Biophys Rev, 2015, 7(4): 399-406. DOI: 10.1007/s12551-015-0182-6.
8. Cervo S, De Paoli P, Perin T, et al. Cost-effective organization of an institutional human cancer biobank in a clinical setting: CRO-Biobank experience toward harmonization[J/OL]. Int J Biol Markers, 2015, 30(2): e243-e251[2015-05-26]. https://pubmed.ncbi.nlm.nih.gov/25744364/. DOI: 10.5301/jbm.5000138.
9. Skeie JM, Tsang SH, Zande RV, et al. A biorepository for ophthalmic surgical specimens[J]. Proteomics Clin Appl, 2014, 8(3-4): 209-217. DOI: 10.1002/prca.201300043.
10. Reis ST, Feitosa EB, Pontes-Junior J, et al. Tumor banks: the cornerstone of basic research in urology[J]. Int Braz J Urol, 2010, 36(3): 348-354. DOI: 10.1590/s1677-55382010000300012.
11. 张赛, 吴静, 周佳宜, 等. 妇产科专科生物样本库3.0版本的建立与管理[J]. 复旦学报(医学版), 2023, 50(3): 456-461. DOI: 10.3969/j.issn.1672-8467.2023.03.019.Zhang S, Wu J, Zhou JY, et al. Establishment and management of obstetric and gynecologic biobank 3.0[J]. Fudan Univ J Med Sci, 2023, 50(3): 456-461. DOI: 10.3969/j.issn.1672-8467.2023.03.019.
12. 张欣冉, 张梅, 李艳英, 等. 矮小症生物样本库建立与管理[J]. 中国医药生物技术, 2023, 18(2): 162-164. DOI: 10.3969/j.issn.1673-713X.2023.02.012.Zhang XR, Zhang M, Li YY, et al. Establishment and management of a biobank for dwarfism[J]. Chin Med Biotechnol, 2023, 18(2): 162-164. DOI: 10.3969/j.issn.1673-713X.2023.02.012.
13. 郭艺博, 刘怡文, 杨海军, 等. 高发区食管癌生物样本库的建立与管理[J]. 食管疾病, 2022, 4(1): 55-58. DOI: 10.15926/j.cnki.issn2096-7381.2022.01.014.Guo YB, Liu YW, Yang HJ, et al. Establishment and management of esophageal cancer biobank in high incidence area[J]. Journal of Esophageal Diseases, 2022, 4(1): 55-58. DOI: 10.15926/j.cnki.issn2096-7381.2022.01.014.
14. 秦玲莎, 王欢, 张恬, 等. 地市级医院建设脑血管病专病生物样本库的可行性探讨[J]. 中国标准化, 2022, 11(22): 239-242. DOI: 10.3969/j.issn.1002-5944.2022.22.049.Qin LS, Wang H, Zhag T, et al. Discussion on the feasibility of constructing biobank for cerebrovascular diseases in prefecture-level hospitals[J]. China Standardization, 2022, 11(22): 239-242. DOI: 10.3969/j.issn.1002-5944.2022.22.049.
15. 喻晶晶, 肖巍, 李娅妮, 等. 肝癌生物样本库的标准化建立与信息化管理[J]. 临床肝胆病杂志, 2022, 38(5): 1092-1096. DOI: 10.3969/j.issn.1001-5256.2022.05.022.Yu JJ, Xiao W, Li YN, et al. Standardized establishment and informationized management of liver cancer biobank[J]. J Chin Hepatol, 2022, 38(5): 1092-1096. DOI: 10.3969/j.issn.1001-5256.2022.05.022.
16. 林金嬉, 梁宪红, 李上智, 等. 中国脑血管病多中心临床研究生物样本库建设模式探讨[J]. 中国卒中杂志, 2021, 16(6): 567-573. DOI: 10.3969/j.issn.1673-5765.2021.06.007.Lin JX, Liang XH, Li SZ, et al. Exploring the construction model of multi-center clinical research biobank for cerebrovascular disease in China[J]. Chin J Stroke, 2021, 16(6): 567-573. DOI: 10.3969/j.issn.1673-5765.2021.06.007.
17. 张林, 姚品芳, 刘媛媛, 等. 湖北省肿瘤医院3.0版肿瘤生物样本库的建立与管理[J]. 中国肿瘤, 2021, 30(1): 48-53. DOI: 10.11735/j.issn.1004-0242.2021.01.A005.Zhang L, Yao PF, Liu YY, et al. Establishment and management of tumor biobank 3.0 in Hubei Cancer Hospital[J]. China Cancer, 2021, 30(1): 48-53. DOI: 10.11735/j.issn.1004-0242.2021.01. A005. DOI: 10.11735/j.issn.1004-0242.2021.01.A005.
18. 宋金云, 赵宏宇. 不明原因肝病生物样本库的建立与管理[J]. 肝脏, 2021, 26(2): 199-201. DOI: 10.3969/j.issn.1008-1704.2021.02.027.Song JY, Zhao HY. Establishment and management of biobank for unknown etiology liver disease[J]. Chinese Hepatology, 2021, 26(2): 199-201. DOI: 10.3969/j.issn.1008-1704.2021.02.027.
19. Gao Z, Tan J, Wang S, et al. The xiangya ocular tumor bank: a disease-specific biobank for advancing translational research into ocular tumors[J/OL]. Front Med (Lausanne), 2022, 8: 774624[2022-01-27]. https://pubmed.ncbi.nlm.nih.gov/35155464/. DOI: 10.3389/fmed.2021.774624.
20. Yang P, Du L, Ye Z. How to deal with uveitis patients?[J]. Curr Mol Med, 2018, 17(7): 468-470. DOI: 10.2174/15665240186661 80207153342.
21. 郑雪妮, 段小红. 口腔罕见病与遗传病生物样本库的建立与完善[J]. 实用口腔医学杂志, 2016, 32(6): 773-777. DOI: 10.3969/j.issn.1001-3733.2016.06.006.Zheng XN, Duan XH. Developmentofa biobank oforalraredisessesand geneticdiseases[J]. J Pract Stomatol, 2016, 32(6): 773-777. DOI: 10.3969/j.issn.1001-3733.2016.06.006.
22. 王敏, 高志梅, 吕志宝, 等. 儿童专科医院特色生物样本库的建立与应用[J]. 中国医药生物技术, 2016, 11(3): 280-284. DOI: 10.3969/j.issn.1673-713X.2016.03.017.Wang M, Gao ZM, Lyu ZB, et al. Establishment and application of a characteristic biobank in children's specialized hospitals[J]. Chin Med Biotechnol, 2016, 11(3): 280-284. DOI: 10.3969/j.issn.1673-713X.2016.03.017.
23. Yang Y, Liu YM, Wei MY, et al. The liver tissue bank and clinical database in China[J]. Front Med China, 2010, 4(4): 443-447. DOI: 10.1007/s11684-010-0190-7.
24. Li H, Qiu Y, Zhang X, et al. Establishment of a lung cancer biobank of a southern chinese population[J]. J Thorac Dis, 2009, 1(1): 17-22.
25. 丁玲, 丁斐, 王钊, 等. 生物样本库行业管理规范[M]//陈曲波. 生物样本库信息系统功能设计与实践. 北京: 人民卫生出版社, 2022: 1-10.Ding L, Ding F, Wang Z, et al. Biobank industry management standard[M]//Chen QB. Functional design and practice of biobank information system. Beijing: People's Health Publishing House, 2022: 1-10.
26. 国家卫生健康委关于印发“十四五”全国眼健康规划(2021-2025年)的通知. 国卫医发〔2022〕1号. 2022-01-04. https://www.gov.cn/zhengce/zhengceku/2022-01/17/content_5668951.htm.Circular of the National Health Commission on the issuance of the National Eye Health Plan for the 14th Five-Year Plan (2021-2025). National Health and Medical Development [2022] No. 1. 2022-01-04. https://www.gov.cn/zhengce/zhengceku/2022-01/17/content_5668951.htm.
27. 王乐, 刘苏来, 蒋宇, 等. 肿瘤生物样本库的发展现状及探讨[J]. 现代肿瘤医学, 2020, 28(5): 832-835. DOI: 10.3969/j.issn.1672-4992.2020.05.033.Wang L, Liu SL, Jiang Y, et al. Development status and discussion of biobank[J]. Modern Oncology, 2020, 28(5): 832-835. DOI: 10.3969/j.issn.1672-4992.2020.05.033.

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Construction of fundus disease-specific biobank: an evidence-based analysis and inspiration

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