Research progress of clinical symptoms and treatment of primary uveal mucosa-associated lymphoid tissue lymphoma_Chinese Journal of Ocular Fundus Diseases

Authors：

Chen Xin , Zhang Lili ,  Zhang Ting , Chen Qian , Bi Yingwen , Xu Gezhi

Department of Ophthalmology, Eye and ENT Hospital of Fudan University, Key Laboratory of Visual Impairment, Restoration of Shanghai and Key Laboratory of Myopia of State Health Ministry, Fudan University, Shanghai 200031, China;

Corresponding author：

Zhang Ting, Email: tina-chang07@163.com

Keywords：

Mucosa-associated lymphoid tissue lymphoma; B-cell; Marginal zone; Uveal neoplasms; Review

DOI：

10.3760/cma.j.cn511434-20240305-00091

Video：

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Abstract Full text Figures/Tables Video References Cited by

Mucosa-associated lymphoid tissue (MALT) lymphoma is an indolent B cell derived non-Hodgkin's lymphoma. It is the main type of uveal lymphoma and is extremely rare. The pathogenesis of ocular MALT lymphoma remains unclear. It is now considered to be associated with many causes. The manifestations of primary uveal MALT lymphoma differ. So sometimes it is necessary to diagnose depending on diversity of auxiliary tests. Ultrasound examination shows typical low and homogeneous internal reflectivity, with blood flow signal. Optical coherence tomography, fundus imaging, fundus angiography, magnetic resonance imaging and positron emission tomography computerized tomography can assist diagnosing. Primary uveal MALT lymphoma is sensitive to radiation therapy, chemotherapy and biotherapy have positive influence too. The prognosis of uveal MALT lymphoma is good, but its early diagnosis is rather challenging. The nonspecific clinical manifestations and the rarity of the disease can confound the initial diagnosis, resulting in delayed treatments which may cause irreversible vision loss.

Citation： Chen Xin, Zhang Lili, Zhang Ting, Chen Qian, Bi Yingwen, Xu Gezhi. Research progress of clinical symptoms and treatment of primary uveal mucosa-associated lymphoid tissue lymphoma. Chinese Journal of Ocular Fundus Diseases, 2024, 40(8): 656-662. doi: 10.3760/cma.j.cn511434-20240305-00091 Copy

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4. Schreuder MI, Van Den Brand M, Hebeda KM, et al. Novel developments in the pathogenesis and diagnosis of extranodal marginal zone lymphoma[J]. J Hematop, 2017, 10(3-4): 91-107. DOI: 10.1007/s12308-017-0302-2.
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6. Rasić DM, Stanković Z, Terzić T, et al. Primary extranodal marginal zone lymphoma of the uvea associated with massive diffuse epibulbar extension and focal infiltration of the optic nerve and meninges, clinically presented as uveitis masquerade syndrome: a case report[J]. Med Oncol, 2010, 27(3): 1010-1016. DOI: 10.1007/s12032-009-9325-6.
7. Byrne GI, Ojcius DM. Chlamydia and apoptosis: life and death decisions of an intracellular pathogen[J]. Nat Rev Microbiol, 2004, 2(10): 802-808. DOI: 10.1038/nrmicro1007.
8. Husain A, Roberts D, Pro B, et al. Meta-analyses of the association between chlamydia psittaci and ocular adnexal lymphoma and the response of ocular adnexal lymphoma to antibiotics[J]. Cancer, 2007, 110(4): 809-815. DOI: 10.1002/cncr.22843.
9. Coupland SE, Damato B. Understanding intraocular lymphomas[J]. Clin Experiment Ophthalmol, 2008, 36(6): 564-578. DOI: 10.1111/j.1442-9071.2008.01843.x.
10. Wang Z, Liu Y, Mo J, et al. Mucosal associated lymphoid tissue lymphoma of the uvea: an analysis of 3 cases[J]. BMC Ophthalmol, 2022, 22(1): 371. DOI: 10.1186/s12886-022-02598-2.
11. Mahdizad Z, Khalili Pour E, Mehrabi Bahar M, et al. Management of primary choroidal lymphoma presenting as extensive serous retinal detachment and salmon patch of bulbar conjunctiva: a case report[J]. J Med Case Reports, 2022, 16(1): 162. DOI: 10.1186/s13256-022-03373-z.
12. Sarraf D, Jain A, Dubovy S, et al. Mucosa-associated lymphoid tissue lymphoma with intraocular involvement[J]. Retina, 2005, 25(1): 94-98. DOI: 10.1097/00006982-200501000-00018.
13. Coutinho AB, Muccioli C, Martins MC, et al. Extranodal B-cell lymphoma of the uvea: a case report[J]. Can J Ophthalmol, 2005, 40(5): 623-626. DOI: 10.1016/s0008-4182(05)80058-4.
14. Freedman K, Shenoy S. Mucosa-associated lymphoid tissue lymphoma with intraocular and orbital involvement: case presentation and review of the literature[J]. Orbit, 2018, 37(4): 243-247. DOI: 10.1080/01676830.2017.1383479.
15. Jusufbegovic D, Kim V, Char DH. Primary uveal lymphoma with epibulbar extension masquerading as an intraocular inflammation[J/OL]. Can J Ophthalmol, 2015, 50(1): e24-e26[2015-02-01]. https://pubmed.ncbi.nlm.nih.gov/25677298/. DOI: 10.1016/j.jcjo.2014.11.018.
16. Koç I, Kiratli H, Kapucu Y, et al. Primary ciliary body marginal zone lymphoma presenting as hemorrhagic hypopyon[J]. Ocul Immunol Inflamm, 2021, 29(3): 496-499. DOI: 10.1080/09273948.2020.1815798.
17. Gillan EC, Ancona-Lezama D, Shields CL. Visual acuity loss in a healthy man[J]. JAMA Ophthalmol, 2020, 138(7): 789-790. DOI: 10.1001/jamaophthalmol.2020.0452.
18. Zhang L, Zhang T, Xu G, et al. Multipurpose ultrasonographic characteristics of primary uveal MALT lymphoma[J]. Graefe's Arch Clin Exp Ophthalmol, 2023, 261(8): 2383-2394. DOI: 10.1007/s00417-022-05958-2.
19. Erickson B, Mantopoulos D, Schoenfield L, et al. Multimodal imaging and clinicopathologic correlation in primary uveal lymphoma[J]. Case Report Ophthalmol, 2016, 7(1): 39-43. DOI: 10.1159/000442743.
20. Kumar V, Surve A, Kumawat D, et al. Ultra-wide field retinal imaging: a wider clinical perspective[J]. Indian J Ophthalmol, 2021, 69(4): 824-835. DOI: 10.4103/ijo.IJO_1403_20.
21. Gao X, Li B, You Q, et al. Primary extranodal marginal zone B-cell lymphoma with diffuse uveal involvement and focal infiltration of the trabecular meshwork: a case report and review of literature[J]. BMC Ophthalmol, 2015, 15: 48. DOI: 10.1186/s12886-015-0038-7.
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