Zhang Zhiping 1,2 , Wang Hongyan 2 , Xie Xiao 2 , Meng Jie 2 , Wang Jinyan 2 , He Xu 1,2 , Zhao Siping 1,2 , Liu Tingting 2,3,4
  • 1. First Clinical Medical College, Shandong University of Traditional Chinese Medicine, Jinan 250014, China;
  • 2. Eye Institute of Shandong First Medical University, Eye Hospital of Shandong First Medical University (Shandong Eye Hospital), Jinan 250002, China;
  • 3. School of Ophthalmology, Shandong First Medical University, Jinan 250062, China;
  • 4. State Key Laboratory Cultivation Base, Shandong Provincial Key Laboratory of Ophthalmology, Qingdao 266071, China;
Liu Tingting, Email: tingtingliu@vip.sina.com
Age-related macular degeneration; Subretinal drusenoid deposit; Reticular pseudophakic; Multimodal imaging; Diagnostic value
10.3760/cma.j.cn511434-20240407-00138
Export PDF Favorites Scan Get Citation

Abstract Full text Figures/Tables References Cited by

Objective To observe the multi-modal fundus imaging features of subretinal drusenoid deposit (SDD) in age-related macular degeneration (AMD), and observe image features. Methods A prospective clinical study. From December 2019 to December 2023, 65 patients (104 eyes) with a diagnosis of AMD-SDD by spectral domain optical coherence tomography (SD-OCT) examination in Shandong Eye Hospital were included. All eyes were examined by best corrected visual acuity (BCVA), traditional color fundus photography (CFP), ultra-wide-angle scanning laser fundus imaging (UWF), multicolor scanning laser fundus imaging (MC) and SD-OCT. The standard MC images were obtained by using Spectralis HRA+OCT for MC examination. The multi-mode image characteristics of SDD were analyzed retrospectively. Area under curve (AUC) was used to evaluate the sensitivity and specificity of CFP, MC and UWF in detecting SDD. Results Among 65 patients with SDD, 29 cases of males (52 eyes) and 36 cases of females (52 eyes) was included. There were 26 patients with unilateral SDD and 39 patients with bilateral SDD. The average age was (71.74±10.97) years. The early, middle and late stages of AMD were 31 (29.8%, 31/104), 24 (23.1%, 24/104), 49 (47.1%, 49/104) eyes, respectively. The SDD detected by CFP, MC and UWF was 76 (73.1%, 76/104), 94 (90.4%, 94/104), 96 (92.3%, 96/104) eyes. CFP showed that the edge of SDD in the macular area was blurred. UWF showed that the dot and the ribbon SDD were light yellow pale discrete deposits and light yellow interlaced network deposits respectively. MC showed the dot SDD had a strong yellow-green circular reflection, while the edge of the ribbon SDD was surrounded by a weak reflection, and the boundary was clear. SD-OCT showed that SDD had strong reflection signal, which was located between the retinal pigment epithelium layer and the photoreceptor cell layer. The dot SDD could break through the ellipsoid zone and caused slight uplift or interruption of the external membrane, showing a cone-like strong reflection signal. While the ribbon SDD showed a continuous "hill-like" protrusion, which hardly broke through ellipsoid zone. The sensitivity and specificity of CFP, MC and UWF for SDD were 73.1%, 90.4%, 92.3% and 61.1%, 94.4% and 83.3%, respectively. Conclusions MC and UWF show high sensitivity and specificity in diagnosing AMD-SDD, which is superior to CFP. SD-OCT can effectively reveal the location and morphoLogical characteristics of SDD under retina.

Citation： Zhang Zhiping, Wang Hongyan, Xie Xiao, Meng Jie, Wang Jinyan, He Xu, Zhao Siping, Liu Tingting. Diagnostic value and characteristic analysis of multimodal imaging in subretinal drusenoid deposit in age-related macular degeneration. Chinese Journal of Ocular Fundus Diseases, 2024, 40(9): 693-698. doi: 10.3760/cma.j.cn511434-20240407-00138 Copy

  • Previous Article

    Evaluation of conjunctival sac culture findings prior to intravitreal injection

  • Next Article

    Correlation between systemic immune inflammation index and diabetic epiretinal membranes