Bronchopulmonary dysplasia (BPD) and retinopathy of prematurity (ROP) are common and critically important diseases of preterm infants. The common feature of both conditions is altered angiogenesis and pathological changes in the case of incomplete organ development. The interaction of multiple factors leads to abnormal angiogenesis, which not only increases the possibility of comorbidity of BPO and ROP, but also reveals the potential co-pathogenesis between the two. However, the specific mechanism of this angiogenic balance in the occurrence and development of BPD or ROP is still unclear, and there are no animal models to explore the pathogenesis of both diseases. At present, effective prevention measures for BPO and ROP are still lacking, and treatment methods mainly rely on drug therapy and surgery. In the future, more studies should be conducted to find common therapeutic targets for factors affecting angiogenesis, so as to provide better treatment options for BPD and ROP and improve the effectiveness of treatment.
Citation:
Zhang Caiyu, Sun Huiqing. Research progress on the correlation between bronchopulmonary dysplasia and retinopathy of prematurity. Chinese Journal of Ocular Fundus Diseases, 2025, 41(2): 163-168. doi: 10.3760/cma.j.cn511434-20240925-00357
Copy
Copyright © the editorial department of Chinese Journal of Ocular Fundus Diseases of West China Medical Publisher. All rights reserved
1. |
|
2. |
|
3. |
|
4. |
|
5. |
|
6. |
|
7. |
|
8. |
|
9. |
|
10. |
|
11. |
|
12. |
|
13. |
Sonny S, Yuan H, Chen S, et al. GSDMD deficiency ameliorates hyperoxia-induced BPD and ROP in neonatal mice[J/OL]. Sci Rep, 2023, 13(1): 143[2023-01-04]. https://pubmed.ncbi.nlm.nih.gov/36599874/. DOI: 10.1038/s41598-022-27201-y.
|
14. |
|
15. |
|
16. |
|
17. |
|
18. |
|
19. |
|
20. |
Donohue PK, Gilmore MM, Cristofalo E, et al. Inhaled nitric oxide in preterm infants: a systematic review[J/OL]. Pediatrics, 2011, 127(2): e414-e422[2011-01-10]. https://pubmed.ncbi.nlm.nih.gov/21220391/. DOI: 10.1542/peds.2010-3428.
|
21. |
|
22. |
|
23. |
Bhat R, Salas AA, Foster C, et al. Prospective analysis of pulmonary hypertension in extremely low birth weight infants[J/OL]. Pediatrics, 2012, 129(3): e682-e689[2012-02-06]. https://pubmed.ncbi.nlm.nih.gov/22311993/. DOI: 10.1542/peds.2011-1827.
|
24. |
|
25. |
|
26. |
|
27. |
Capoluongo E, Ameglio F, Lulli P, et al. Epithelial lining fluid free IGF-I-to-PAPP-A ratio is associated with bronchopulmonary dysplasia in preterm infants[J/OL]. Am J Physiol Endocrinol Metab, 2007, 292(1): E308-313[2006-09-05]. https://pubmed.ncbi.nlm.nih.gov/16954333/. DOI: 10.1152/ajpendo.00251.2006.
|
28. |
|
29. |
|
30. |
|
31. |
|
32. |
|
33. |
|
34. |
|
35. |
|
36. |
|
37. |
|
38. |
|
39. |
|
40. |
|
41. |
|
42. |
|
43. |
|
44. |
|
45. |
|
46. |
|
47. |
|
48. |
|
49. |
|
50. |
|
51. |
|
52. |
|
53. |
|
54. |
Thomas W, Speer CP. Nonventilatory strategies for prevention and treatment of bronchopulmonary dysplasia--what is the evidence?[J]. Neonatology, 2008, 94(3): 150-159. DOI: 10.1159/000143719.
|
55. |
Ambalavanan N, Tyson JE, Kennedy KA, et al. Vitamin A supplementation for extremely low birth weight infants: outcome at 18 to 22 months[J/OL]. Pediatrics, 2005, 115(3): e249-e254[2005-02-15]. https://pubmed.ncbi.nlm.nih.gov/15713907/. DOI: 10.1542/peds.2004-1812.
|
56. |
|
57. |
|
58. |
Darlow BA, Graham PJ. Vitamin A supplementation to prevent mortality and short and long-term morbidity in very low birthweight infants[J/OL]. Cochrane Database Syst Rev, 2007, 1(4): CD000501[2007-10-17]. https://pubmed.ncbi.nlm.nih.gov/17943744/DOI: 10.1002/14651858.CD000501.pub2.
|
59. |
|
60. |
|
61. |
|
62. |
|
63. |
|
64. |
|
65. |
Singh JK, Wymore EM, Wagner BD, et al. Relationship between severe bronchopulmonary dysplasia and severe retinopathy of prematurity in premature newborns[J/OL]. J AAPOS, 2019, 23(4): e1-e4[2019-05-24]. https://pubmed.ncbi.nlm.nih.gov/31132481/. DOI: 10.1016/j.jaapos.2019.02.008.
|
66. |
|
67. |
|
68. |
|
69. |
|
70. |
|
71. |
|
- 1.
- 2.
- 3.
- 4.
- 5.
- 6.
- 7.
- 8.
- 9.
- 10.
- 11.
- 12.
- 13. Sonny S, Yuan H, Chen S, et al. GSDMD deficiency ameliorates hyperoxia-induced BPD and ROP in neonatal mice[J/OL]. Sci Rep, 2023, 13(1): 143[2023-01-04]. https://pubmed.ncbi.nlm.nih.gov/36599874/. DOI: 10.1038/s41598-022-27201-y.
- 14.
- 15.
- 16.
- 17.
- 18.
- 19.
- 20. Donohue PK, Gilmore MM, Cristofalo E, et al. Inhaled nitric oxide in preterm infants: a systematic review[J/OL]. Pediatrics, 2011, 127(2): e414-e422[2011-01-10]. https://pubmed.ncbi.nlm.nih.gov/21220391/. DOI: 10.1542/peds.2010-3428.
- 21.
- 22.
- 23. Bhat R, Salas AA, Foster C, et al. Prospective analysis of pulmonary hypertension in extremely low birth weight infants[J/OL]. Pediatrics, 2012, 129(3): e682-e689[2012-02-06]. https://pubmed.ncbi.nlm.nih.gov/22311993/. DOI: 10.1542/peds.2011-1827.
- 24.
- 25.
- 26.
- 27. Capoluongo E, Ameglio F, Lulli P, et al. Epithelial lining fluid free IGF-I-to-PAPP-A ratio is associated with bronchopulmonary dysplasia in preterm infants[J/OL]. Am J Physiol Endocrinol Metab, 2007, 292(1): E308-313[2006-09-05]. https://pubmed.ncbi.nlm.nih.gov/16954333/. DOI: 10.1152/ajpendo.00251.2006.
- 28.
- 29.
- 30.
- 31.
- 32.
- 33.
- 34.
- 35.
- 36.
- 37.
- 38.
- 39.
- 40.
- 41.
- 42.
- 43.
- 44.
- 45.
- 46.
- 47.
- 48.
- 49.
- 50.
- 51.
- 52.
- 53.
- 54. Thomas W, Speer CP. Nonventilatory strategies for prevention and treatment of bronchopulmonary dysplasia--what is the evidence?[J]. Neonatology, 2008, 94(3): 150-159. DOI: 10.1159/000143719.
- 55. Ambalavanan N, Tyson JE, Kennedy KA, et al. Vitamin A supplementation for extremely low birth weight infants: outcome at 18 to 22 months[J/OL]. Pediatrics, 2005, 115(3): e249-e254[2005-02-15]. https://pubmed.ncbi.nlm.nih.gov/15713907/. DOI: 10.1542/peds.2004-1812.
- 56.
- 57.
- 58. Darlow BA, Graham PJ. Vitamin A supplementation to prevent mortality and short and long-term morbidity in very low birthweight infants[J/OL]. Cochrane Database Syst Rev, 2007, 1(4): CD000501[2007-10-17]. https://pubmed.ncbi.nlm.nih.gov/17943744/DOI: 10.1002/14651858.CD000501.pub2.
- 59.
- 60.
- 61.
- 62.
- 63.
- 64.
- 65. Singh JK, Wymore EM, Wagner BD, et al. Relationship between severe bronchopulmonary dysplasia and severe retinopathy of prematurity in premature newborns[J/OL]. J AAPOS, 2019, 23(4): e1-e4[2019-05-24]. https://pubmed.ncbi.nlm.nih.gov/31132481/. DOI: 10.1016/j.jaapos.2019.02.008.
- 66.
- 67.
- 68.
- 69.
- 70.
- 71.