Full-field flash electroretinogram following up for children with history of pre-threshold or threshold retinopathy of prematurity_Chinese Journal of Ocular Fundus Diseases

Authors：

 WangPing , TianMi , ZhangJinmei , 唐景 , 王曦琅 , 陶利娟

Department of Ophthalmology, Children's Hospital of Hunan Province, Changsha 410007, China;

Corresponding author：

WangPing, Email: wangping22@sina.com

Keywords：

Vision,ocular/physiology; Retinopathy of prematurity/physiology; Electroretinography

DOI：

10.3760/cma.j.issn.1005-1015.2014.01.006

Video：

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Objective To evaluate the characteristics of electroretinagram (EGR) in children with history of pre-threshold or threshold retinopathy of prematurity (ROP). Methods A total of 24 children (48 eyes) with history of pre-threshold ROP or threshold ROP received F-ERG examination.Ten age and body weight-matched children with a history of premature birth (20 eyes) but without ROP were recruited as control group. The rod response, maximal rod-cone response and cone response of F-ERG were recorded respectively following the International Standard Protocal of ISCEV (2000 version).The latency and amplitude of a-wave and b-wave of various responses were analyzed. The trial was approved by the Ethic Committee of Hunan Children's Hospital and informed consent was obtained from the parents of patients prior to any medical procedure. Results There was significant difference between ROP and control group in rod response,the latency was longer (t=5.643,P<0.05) and the amplitude was lower in ROP group(t=7.068,P<0.05).In maximal rod-cone response both in a and b wave, the latency wave was longer(t=3.099, 2.886;P<0.05) and the amplitude was lower(t=5.614, 2.850;P<0.05) in ROP group. But there is no difference between ROP and control group in cone response latency(t=0.819, 0.948)and amplitude(t=0.904, 0.850). Conclusion ERG in ROP children with history of pre-threshold or threshold ROP is abnormal, which mainly in rod response,but the cone response remains normal.

Citation： WangPing, TianMi, ZhangJinmei. Full-field flash electroretinogram following up for children with history of pre-threshold or threshold retinopathy of prematurity. Chinese Journal of Ocular Fundus Diseases, 2014, 30(1): 21-23. doi: 10.3760/cma.j.issn.1005-1015.2014.01.006 Copy

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7.	Maureen EH, Anne M, Anne BF, et al. Long term effects of retinopathy of prematurity (ROP) on rod and rod-driven function[J]. Doc Ophthalmol, 2011, 122:19-27.
8.	Fulton AB, Hansen RM, Moskowitz A, et al. The neurovascular retina in retinopathy of prematurity[J]. Prog Retin Eye Res,2009,28:452-482.
9.	Akula JD, Mocko JA, Moskowitz A, et al. The oscillatory potentials of the darkadapted electroretinogram in retinopathy of prematurity[J]. Invest Ophthalmol Vis Sci, 2007, 48:5788-5797.
10.	贾洪娟,项道满,毛娅妮,等. 早产儿视网膜病变激光光凝治疗后视网膜功能发育状况观察[J]. 中华眼底病杂志,2011,27:1005-1015.
11.	Fulton AB, Hansen RM, Moskowitz A.The cone electroretinogram in retinopathy of prematurity[J].Invest Ophthalmol Vis Sci,2008,49:814-819.
12.	Fulton AB, Hansen RM,Moskowitz A.Development of rod function in term born and former preterm subjects[J].Optom Vis Sci,2009,86:653-658.
13.	Thomas AR.The development of the retina[M]//Stepled JR.Retina. 3rd eds.St Louis:Mosby Press Inc,2001:3-20.

1. Baker PS, Tasman W. Myopia in adults with retinopathy of prematurity[J]. Am J Ophthalmol, 2008, 145:1090-1094.
2. Cook A, White S, Batterbury M, et al. Ocular growth and refractive error development in premature infants with or without retinopathy of prematurity[J]. Invest Ophthalmol Vis Sci, 2008, 49:5199-5207.
3. Holmstrom G, Rydberg A, Larsson E. Prevalence and development of strabismus in 10-year-old premature children:a population-based study[J]. J Pediatr Ophthalmol Strabismus, 2006, 43:346-352.
4. Ecsedy M, Szamosi A, Karko C, et al. A comparison of macular structure imaged by optical coherence tomography in preterm and full-term children[J]. Invest Ophthalmol Vis Sci, 2007, 48:5207-5211.
5. International Committee for the Classification of Retinopathy of Prematurity.The international classification of retinopathy of prematurity revisited[J]. Arch Ophthalmol, 2005, 123:991-999.
6. Marmor MF, Holder GE, Seeliger MW, et al. Standard for clinical electroretinography (2004 update)[J]. Doc Ophthalmol, 2004,108:107-114.
7. Maureen EH, Anne M, Anne BF, et al. Long term effects of retinopathy of prematurity (ROP) on rod and rod-driven function[J]. Doc Ophthalmol, 2011, 122:19-27.
8. Fulton AB, Hansen RM, Moskowitz A, et al. The neurovascular retina in retinopathy of prematurity[J]. Prog Retin Eye Res,2009,28:452-482.
9. Akula JD, Mocko JA, Moskowitz A, et al. The oscillatory potentials of the darkadapted electroretinogram in retinopathy of prematurity[J]. Invest Ophthalmol Vis Sci, 2007, 48:5788-5797.
10. 贾洪娟,项道满,毛娅妮,等. 早产儿视网膜病变激光光凝治疗后视网膜功能发育状况观察[J]. 中华眼底病杂志,2011,27:1005-1015.
11. Fulton AB, Hansen RM, Moskowitz A.The cone electroretinogram in retinopathy of prematurity[J].Invest Ophthalmol Vis Sci,2008,49:814-819.
12. Fulton AB, Hansen RM,Moskowitz A.Development of rod function in term born and former preterm subjects[J].Optom Vis Sci,2009,86:653-658.
13. Thomas AR.The development of the retina[M]//Stepled JR.Retina. 3rd eds.St Louis:Mosby Press Inc,2001:3-20.

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Full-field flash electroretinogram following up for children with history of pre-threshold or threshold retinopathy of prematurity

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