Choroidal thickness of macular and peripapillary area in malignant glaucoma_Chinese Journal of Ocular Fundus Diseases

Authors：

ChenXiangxi , XiaoHui , GuoXinxing , 米兰 , 黄洁蕾 ,  刘杏

State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou 510060, China;

Corresponding author：

刘杏, Email: liuxing@mail.sysu.edu.cn

Keywords：

Glaucoma/physiopathology; Choroid/physiopathology; Macula lutea; Optic disk; Tomography, optical coherence

DOI：

10.3760/cma.j.issn.1005-1015.2014.06.011

Video：

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Objective To compare the choroidal thickness (CT) of macular and peripapillary area among malignant glaucoma(MG), chronic primary angle-closure glaucoma (CPACG) and normal control eyes. And to investigate the correlation between CT and MG. Methods Sixteen subjects (32 eyes) with MG, 31 (31 eyes) with CPACG and 32 (32 eyes) normal controls were collected. MG eyes and the fellow non-MG eyes were included in the MG group. CT of all subjects was measured in the fovea, 1mm and 3mm to the fovea and peripapillary area using enhanced-depth imaging technique of optical coherence tomography (OCT-EDI). The average of CT in fovea by horizontal and vertical macular scan was defined as the average CT in fovea. The average of temporal, superior, nasal and inferior CT in 1 mm and 3 mm to the fovea were measured respectively. The average of temporal, superior, nasal and inferior CT was defined as the average CT in peripapillary area. The differences of CT among MG, CPACG and normal controls were compared. And the differences of CT between MG eyes and the fellow non-MG eyes were compared. Results After eliminating the influence of age, the average CT of MG in the fovea, 1mm and 3mm to the fovea was significantly thicker than that of CPACG and normal controls (P < 0.05). And the average CT of CPACG in the fovea, 1mm and 3mm to the fovea was significantly thicker than that of normal controls (P < 0.05). In peripapillary area, the temporal, superior and inferior CT of MG was significantly thicker than that of CPACG and normal controls (P < 0.05). There was no significant difference of CT in peripapillary area between CPACG and normal controls (P > 0.05). In the fovea, 1mm and 3mm to the fovea and peripapillary area, there was no significant difference of CT between MG eye and the fellow non-MG eye in MG group (t=－1.029~－0.130, P > 0.05). Conclusions The choroid thickness of macular and peripapillary area in MG eyes is thicker than that of CPACG and the normal controls. An increased CT of macular and peripapillary area may be one of the risk factors for MG.

Citation： ChenXiangxi, XiaoHui, GuoXinxing. Choroidal thickness of macular and peripapillary area in malignant glaucoma. Chinese Journal of Ocular Fundus Diseases, 2014, 30(6): 578-582. doi: 10.3760/cma.j.issn.1005-1015.2014.06.011 Copy

1.	Liu X, Li M, Cheng B. Phacoemulsification combined with posterior capsulorhexis and anterior vitrectomy in the management of malignant glaucoma in phakic eyes[J]. Acta Ophthalmol, 2013, 91:660-566.
2.	Shahid H, Salmon JF. Malignant glaucoma:a review of the modern literature. J Ophthalmol, 2012, 2012:852659.[2012-01-09]http://www.hindawi.com/journals/joph/2012/852659/.
3.	刘杏, 李媚, 王忠浩.相干光断层扫描检测原发性闭角型青光眼的眼前节生物学参数[J].中华眼科杂志, 2013, 49:109-115.
4.	Quigley HA, Friedman DS, Congdon NG. Possible mechanisms of primary angle-closure and malignant glaucoma[J]. J Glaucoma, 2003, 12:167-180.
5.	Quigley HA. What's the choroid got to do with angle closure?[J]. Arch Ophthalmol, 2009, 127:693-694.
6.	李加青, 丁小燕, 曾婧.慢性中心性浆液性脉络膜视网膜病变患者双眼脉络膜厚度频域光相干断层扫描检查分析[J].中华眼底病杂志, 2012, 28:325-328.
7.	Huang J, Wang Z, Wu Z. Comparison of ocular biometry between eyes with chronic primary angle-closure glaucoma and their fellow eyes with primary angle-closure or primary angle-closure suspect. J Glaucoma, 2013.[2013-04-14]http://www.researchgate.net/publication/242653158.
8.	卓业鸿, 葛坚, 刘奕志.恶性青光眼手术治疗远期疗效探讨[J].中国实用眼科杂志, 2004, 22:20-22.
9.	黄圣松, 余敏斌, 刘奕志.晶状体后囊和玻璃体前界膜切开治疗恶性青光眼的临床研究[J].中国实用眼科杂志, 2005, 23:915-918.
10.	Kubota T, Jonas JB, Naumann GO. Decreased choroidal thickness in eyes with secondary angle closure glaucoma:an aetiological factor for deep retinal changes in glaucoma?[J].Br J Ophthalmol, 1993, 77:430-432.
11.	Yin ZQ, Vaegan, Millar TJ, et al. Widespread choroidal insufficiency in primary open-angle glaucoma[J]. J Glaucoma, 1997, 6:23-32.
12.	Grasbon T, Schriever S, Hoops JP. 3-D ultrasound:initial experiences in various eye diseases[J].Ophthalmologe, 2001, 98:88-93.
13.	Spaide RF, Koizumi H, Pozzoni MC. Enhanced depth imaging spectral-domain optical coherence tomography[J]. Am J Ophthalmol, 2008, 146:496-500.
14.	Imamura Y, Fujiwara T, Margolis R, et al. Enhanced depth imaging optical coherence tomography of the choroid in central serous chorioretinopathy[J]. Retina, 2009, 29:1469-1473.
15.	McCourt EA, Cadena BC, Barnett CJ. Measurement of subfoveal choroidal thickness using spectral domain optical coherence tomography[J]. Ophthalmic Surg Lasers Imaging, 2010, 41:528-533.
16.	Maul EA, Friedman DS, Chang DS. Choroidal thickness measured by spectral domain optical coherence tomography:factors affecting thickness in glaucoma patients[J]. Ophthalmology, 2011, 118:1571-1579.
17.	Quigley HA. Angle-closure glaucoma-simpler answers to complex mechanisms:LXVI Edward Jackson Memorial Lecture[J]. Am J Ophthalmol, 2009, 148:657-669.
18.	Silver DM, Geyer O. Pressure-volume relation for the living human eye[J]. Curr Eye Res, 2000, 20:115-120.

1. Liu X, Li M, Cheng B. Phacoemulsification combined with posterior capsulorhexis and anterior vitrectomy in the management of malignant glaucoma in phakic eyes[J]. Acta Ophthalmol, 2013, 91:660-566.
2. Shahid H, Salmon JF. Malignant glaucoma:a review of the modern literature. J Ophthalmol, 2012, 2012:852659.[2012-01-09]http://www.hindawi.com/journals/joph/2012/852659/.
3. 刘杏, 李媚, 王忠浩.相干光断层扫描检测原发性闭角型青光眼的眼前节生物学参数[J].中华眼科杂志, 2013, 49:109-115.
4. Quigley HA, Friedman DS, Congdon NG. Possible mechanisms of primary angle-closure and malignant glaucoma[J]. J Glaucoma, 2003, 12:167-180.
5. Quigley HA. What's the choroid got to do with angle closure?[J]. Arch Ophthalmol, 2009, 127:693-694.
6. 李加青, 丁小燕, 曾婧.慢性中心性浆液性脉络膜视网膜病变患者双眼脉络膜厚度频域光相干断层扫描检查分析[J].中华眼底病杂志, 2012, 28:325-328.
7. Huang J, Wang Z, Wu Z. Comparison of ocular biometry between eyes with chronic primary angle-closure glaucoma and their fellow eyes with primary angle-closure or primary angle-closure suspect. J Glaucoma, 2013.[2013-04-14]http://www.researchgate.net/publication/242653158.
8. 卓业鸿, 葛坚, 刘奕志.恶性青光眼手术治疗远期疗效探讨[J].中国实用眼科杂志, 2004, 22:20-22.
9. 黄圣松, 余敏斌, 刘奕志.晶状体后囊和玻璃体前界膜切开治疗恶性青光眼的临床研究[J].中国实用眼科杂志, 2005, 23:915-918.
10. Kubota T, Jonas JB, Naumann GO. Decreased choroidal thickness in eyes with secondary angle closure glaucoma:an aetiological factor for deep retinal changes in glaucoma?[J].Br J Ophthalmol, 1993, 77:430-432.
11. Yin ZQ, Vaegan, Millar TJ, et al. Widespread choroidal insufficiency in primary open-angle glaucoma[J]. J Glaucoma, 1997, 6:23-32.
12. Grasbon T, Schriever S, Hoops JP. 3-D ultrasound:initial experiences in various eye diseases[J].Ophthalmologe, 2001, 98:88-93.
13. Spaide RF, Koizumi H, Pozzoni MC. Enhanced depth imaging spectral-domain optical coherence tomography[J]. Am J Ophthalmol, 2008, 146:496-500.
14. Imamura Y, Fujiwara T, Margolis R, et al. Enhanced depth imaging optical coherence tomography of the choroid in central serous chorioretinopathy[J]. Retina, 2009, 29:1469-1473.
15. McCourt EA, Cadena BC, Barnett CJ. Measurement of subfoveal choroidal thickness using spectral domain optical coherence tomography[J]. Ophthalmic Surg Lasers Imaging, 2010, 41:528-533.
16. Maul EA, Friedman DS, Chang DS. Choroidal thickness measured by spectral domain optical coherence tomography:factors affecting thickness in glaucoma patients[J]. Ophthalmology, 2011, 118:1571-1579.
17. Quigley HA. Angle-closure glaucoma-simpler answers to complex mechanisms:LXVI Edward Jackson Memorial Lecture[J]. Am J Ophthalmol, 2009, 148:657-669.
18. Silver DM, Geyer O. Pressure-volume relation for the living human eye[J]. Curr Eye Res, 2000, 20:115-120.

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