Retinal hemorrhages in newborns and associated factors_Chinese Journal of Ocular Fundus Diseases

Authors：

 ZhangJianping , MaJinyu , WeiLifang , 莫海明 , 吴凯林

Department of Ophthalmology, Liuzhou Maternity and Children Hospital, Liuzhou 545001, China;

Corresponding author：

ZhangJianping, Email: 13768340179@163.com

Keywords：

Retinal hemorrhage/etiology; Retinal hemorrhage/diagnosis; Infant, newborn; Root cause analysis

DOI：

10.3760/cma.j.issn.1005-1015.2015.02.011

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Objective To investigate the related factors of the retina1 hemorrhage in newborns. Methods 9558 newborns included in this observation between March of 2012 and July of 2013 in our hospital. The fundus was examined by the fully-integrated wide-field digital imaging system RetCamⅢat 0-4 days after born. According to the literature, retinal hemorrhage was classified into degreeⅠ, ⅡandⅢ. The condition for baby and the mother during pregnancy were correlatively analyzed. The other factors were analyzed including twins, premature delivery, big baby, mode of delivery, fetal birth, forceps delivery, suction delivery, asphyxia, jaundice, ABO hemolytic, cranial hematoma, intracranial hemorrhage, maternal age, first-time mom, the maternal previous mode of production, emergency delivery, the first stage of labor prolonged, the second stage of labor prolonged, the third stage of labor prolonged, pregnancy-induced hypertension, gestational diabetes, oxytocin, prenatal body mass index (BMI). Multivariate logistic regression analysis was used. Results In 9558 cases of newborns, retinal hemorrhages were found in 2753 infants (28.8%), including 1137 degreeⅠ(41.3%), 895 degreeⅡ(32.5%) and 721 degreeⅢ(26.2%). Multivariate logistic regression analysis showed that the mode of delivery, asphyxia, jaundice, advanced maternal age, maternal previous birth, prenatal BMI is a risk factor for neonatal values retinal hemorrhage (r=0.146, 5.841, 1.847, 0.071, 0.246, 0.965;P < 0.05). The degree of fundus hemorrhage was not related to birth weight and BMI (P > 0.05). Conclusions The neonatal retinal hemorrhage rate was 28.8%. Mode of delivery, asphyxia, neonatal jaundice, maternal age, the previous mode of delivery of mothers with more than one previous birth, prenatal BMI values may be risk factors lead to retinal hemorrhage.

Citation： ZhangJianping, MaJinyu, WeiLifang. Retinal hemorrhages in newborns and associated factors. Chinese Journal of Ocular Fundus Diseases, 2015, 31(2): 153-156. doi: 10.3760/cma.j.issn.1005-1015.2015.02.011 Copy

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6.	潘建东, 黄崇斌, 陈峰, 等.新生儿视网膜出血及其相关影响因素观察分析[J].中华眼底病杂志, 2013, 29(3):280-283.
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9.	张闻璐.148例新生儿窒息的眼底检查临床探讨[J].华北煤炭医学院学报, 2010, 12(5):682-683.
10.	Emerson MV, Pieramic DJ.Stoessel KM, et al.Incidence and rate of disappearance of retinal hemorrhage in newborns[J].Ophthalmology, 2001, 108(1):36-39.
11.	Choi YJ, Jung MS, Kim SY.Retinal hemorrhage associated with perinatal distress in newborns[J]. Korean J Ophthalmol, 2011, 25(5):311-316.
12.	李树爱, 武传红.新生儿颅内出血并发视网膜出血的相关因素的探讨[J].井岗山医专学报, 2004, 11(6):20-21.
13.	金贞爱, 赵以坤, 金正勇.延边地区新生儿黄疸原因分析[J].中国妇幼保健, 2012, 27(12):1807-1809.
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15.	杜鹃, 李洁.孕妇体重对分娩方式的影响[J].中国实用妇科与产科杂志, 2012, 28(2):108-110.

1. 叶鸿瑁.新生儿窒息及复苏[M]//邵肖梅, 叶鸿瑁, 丘小汕.实用新生儿学.4版.北京:人民卫生出版社, 2011:222-225.
2. 赵培泉.眼部疾病[M]//邵肖梅, 叶鸿昌, 丘小汕.实用新生儿学.4版.北京:人民卫生出版社, 2011:882-891.
3. 中华人民共和国卫生部疾病控制司.中国成人超重和肥胖症预防控制指南[M].北京:人民卫生出版社, 2006:2.
4. Egge K, Lyng G, Maltau JM.Effect of instrumental delivery on the:frequency and severity of retinal hemorrhages in the newborn[J].Acta Obstet Gynecol Scand, 1981, 60(2):153-155.
5. 殷纳新, 袁进, 陈家祺, 等.新生儿视网膜出血广域数字化眼底成像系统分析[J].中国实用眼科杂志, 2013, 2, 31(2):191-193.
6. 潘建东, 黄崇斌, 陈峰, 等.新生儿视网膜出血及其相关影响因素观察分析[J].中华眼底病杂志, 2013, 29(3):280-283.
7. 朱文珲, 骆荣江, 刘韶瑞.高危新生儿眼底出血临床分析[J].中华眼底病杂志, 2012, 28(5):482-484.
8. 陈丽娜, 何晓平, 黄立平, 等.影响足月新生儿眼底出血的临床因素探讨[J].中国医学创新, 2012, 9(21):97-98.
9. 张闻璐.148例新生儿窒息的眼底检查临床探讨[J].华北煤炭医学院学报, 2010, 12(5):682-683.
10. Emerson MV, Pieramic DJ.Stoessel KM, et al.Incidence and rate of disappearance of retinal hemorrhage in newborns[J].Ophthalmology, 2001, 108(1):36-39.
11. Choi YJ, Jung MS, Kim SY.Retinal hemorrhage associated with perinatal distress in newborns[J]. Korean J Ophthalmol, 2011, 25(5):311-316.
12. 李树爱, 武传红.新生儿颅内出血并发视网膜出血的相关因素的探讨[J].井岗山医专学报, 2004, 11(6):20-21.
13. 金贞爱, 赵以坤, 金正勇.延边地区新生儿黄疸原因分析[J].中国妇幼保健, 2012, 27(12):1807-1809.
14. Artal R, Lockwood CJ, Brown HL.Weight gain recommenda-tions in pregnancy and the obesity epidemic[J].Obstet Gynecol, 2010, 115(1):152-155.
15. 杜鹃, 李洁.孕妇体重对分娩方式的影响[J].中国实用妇科与产科杂志, 2012, 28(2):108-110.

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