坎地沙坦对早期糖尿病大鼠视网膜中Akt蛋白及其磷酸化位点表达的影响_Chinese Journal of Ocular Fundus Diseases

Authors：

潘学良 ,  王鲜 , 李志敏 , 杨主敏 , 徐涛

Corresponding author：

王鲜, Email: liangliang830@126.com

Keywords：

糖尿病视网膜病变/药物疗法; 磷脂酰肌醇3-激酶; 腺苷三磷酸双磷酸酶

DOI：

10.3760/cma.j.issn.1005-1015.2015.02.020

Video：

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Citation： 潘学良, 王鲜, 李志敏, 杨主敏, 徐涛. 坎地沙坦对早期糖尿病大鼠视网膜中Akt蛋白及其磷酸化位点表达的影响. Chinese Journal of Ocular Fundus Diseases, 2015, 31(2): 184-186. doi: 10.3760/cma.j.issn.1005-1015.2015.02.020 Copy

1.	刘俊, 裘正军, 江技, 等. Akt和磷酸化Aktl在胰腺癌组织中的表达及意义[J].中华胰腺病杂志, 2010, 10(2):128-130.
2.	肖国华, 王忠保. PKB/Akt在糖尿病及其血管并发症中的调节作用[J].医学研究杂志, 2010, 39(1):13-15.
3.	Zhou MS, Schulman IH, Raij L.Role of angiotensinⅡand oxidative stress in vascular insulin resistance linked to hypertension[J]. Am J Physiol Heart Circ Physiol, 2009, 296(3):H833-839.
4.	黎笑楠, 庞东渤, 赵海雁, 等.坎地沙坦治疗大鼠糖尿病视网膜病变的作用机制[J].国际眼科杂志, 2011, 11(2):226-228.
5.	谭歆, 庞东渤, 赵海燕, 等.坎地沙坦对糖尿病大鼠视网膜VEGF和MCP-1表达的影响[J].国际眼科杂志, 2011, 11(3):406-408.
6.	Guha M, Mackman N. The phosph atidy linositol 3-kinase-Akt. pathway limits lipopoly saccharide activation of signaling pathways and expression of inflame matory mediators in humanmonocytic cells[J]. J Biol Chem, 2002, 277(35):32124-32132.
7.	Kobayashi T, Taguchi K, Yasuhiro T, et al. Impairment of PI3K/Akt pathway underlies attenuated endothelial function in aorta of type 2 diabetic mouse model[J]. Hypertension, 2004, 44(6):956-962.
8.	兰超, 李莉.坎地沙坦对充血性心力衰竭的治疗作用及对内皮素和心钠素水平的影响[J].中国急救医学, 2006, 26(5):323-325.
9.	Sjolie AK, Klein R, Porta M, et al. Effect of candesartan on progression and regression of retinopathy in type 2 diabetes (DIRECT-Protect 2):a randomised placebo-controlled trial[J]. Lancet, 2008, 372(9647):1385-1393.
10.	Schrier RW, Estacio RO, Esler A, et al. Effects of aggressive blood pressure control in normotensive type 2 diabetic patients on albuminuria, retinopathy and strokes[J].Kidney Int, 2002, 61(3):1086-1097.

1. 刘俊, 裘正军, 江技, 等. Akt和磷酸化Aktl在胰腺癌组织中的表达及意义[J].中华胰腺病杂志, 2010, 10(2):128-130.
2. 肖国华, 王忠保. PKB/Akt在糖尿病及其血管并发症中的调节作用[J].医学研究杂志, 2010, 39(1):13-15.
3. Zhou MS, Schulman IH, Raij L.Role of angiotensinⅡand oxidative stress in vascular insulin resistance linked to hypertension[J]. Am J Physiol Heart Circ Physiol, 2009, 296(3):H833-839.
4. 黎笑楠, 庞东渤, 赵海雁, 等.坎地沙坦治疗大鼠糖尿病视网膜病变的作用机制[J].国际眼科杂志, 2011, 11(2):226-228.
5. 谭歆, 庞东渤, 赵海燕, 等.坎地沙坦对糖尿病大鼠视网膜VEGF和MCP-1表达的影响[J].国际眼科杂志, 2011, 11(3):406-408.
6. Guha M, Mackman N. The phosph atidy linositol 3-kinase-Akt. pathway limits lipopoly saccharide activation of signaling pathways and expression of inflame matory mediators in humanmonocytic cells[J]. J Biol Chem, 2002, 277(35):32124-32132.
7. Kobayashi T, Taguchi K, Yasuhiro T, et al. Impairment of PI3K/Akt pathway underlies attenuated endothelial function in aorta of type 2 diabetic mouse model[J]. Hypertension, 2004, 44(6):956-962.
8. 兰超, 李莉.坎地沙坦对充血性心力衰竭的治疗作用及对内皮素和心钠素水平的影响[J].中国急救医学, 2006, 26(5):323-325.
9. Sjolie AK, Klein R, Porta M, et al. Effect of candesartan on progression and regression of retinopathy in type 2 diabetes (DIRECT-Protect 2):a randomised placebo-controlled trial[J]. Lancet, 2008, 372(9647):1385-1393.
10. Schrier RW, Estacio RO, Esler A, et al. Effects of aggressive blood pressure control in normotensive type 2 diabetic patients on albuminuria, retinopathy and strokes[J].Kidney Int, 2002, 61(3):1086-1097.

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Chinese Journal of Ocular Fundus Diseases

坎地沙坦对早期糖尿病大鼠视网膜中Akt蛋白及其磷酸化位点表达的影响

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