The prevalence of age-related macular degeneration in the rural area of Qidong County, Jangsu Province_Chinese Journal of Ocular Fundus Diseases

Authors：

WangYing ,  GuanHuaijin , LuHong , 张国伟 , 薛莹 , 陈佳

Eye Center, The Affiliated Hospital of Nantong University, Nantong 226500, China;

Corresponding author：

GuanHuaijin, Email: wangying2010@139.com

Keywords：

Macular degeneration/epidemiology; Macular degeneration/diagnosis; Macular degeneration/etiology; Data collection

DOI：

10.3760/cma.j.issn.1005-1015.2015.05.012

Video：

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Objective To study the prevalence of age-related macular degeneration (AMD) in the population aged 50 and over in Qidong County of Jangsu Province. Methods 3644 individuals from 4 villages were randomly selected by clustering sampling method, according to the household registration information and door to door visits. Visual acuity was measured by modified Bailey-Lovie E logMAR chart. The examination of eyelids, cornea, lens and fundus were also carried out. The diagnosis of AMD was made according to the clinical hierarchy system by Age-Related Eye Diseases Study. χ² test was used to analyze the prevalence of AMD and its related factors. Results Among 3644 selected individuals, 2985 individuals received examination with a participating rate of 81.92%. In total 97 patients (136 eyes) had AMD with a prevalence rate of 3.25%. Among them, 71 patients (105 eyes) had early stage of AMD (2.38%); 26 patients (31 eyes) had late stage of AMD (0.87%). In these late stage patients, there were 9 patients (13 eyes) of exudative lesions (0.30%). There were 32 male (3.11%) and 65 female (3.32%) patients. There was no statistically significant difference between male and female prevalence (χ²=0.29, P > 0.05). Correlation analysis results showed that the long-term smoking (χ²=15.19) and heart cerebrovascular disease (χ²=81.50) was associated with AMD (P < 0.05). Conclusions The prevalence rate of AMD is 3.25% in the residents aged 50 and above in the rural area of Qidong County, Jangsu Province. Long-term smoking, high blood pressure and cardiovascular disease are the risk factors of AMD.

Citation： WangYing, GuanHuaijin, LuHong. The prevalence of age-related macular degeneration in the rural area of Qidong County, Jangsu Province. Chinese Journal of Ocular Fundus Diseases, 2015, 31(5): 459-461. doi: 10.3760/cma.j.issn.1005-1015.2015.05.012 Copy

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1. 武明星, 郑政, 周希瑗.年龄相关性黄斑变性流行病学研究进展[J].国际眼科杂志, 2015, 15(2) :223-2270.
2. 赵欣, 田碧琪, 郝云赫, 等.北京西长安街社区50岁以上人群年龄相关性黄斑变性患病率调查[J].国际眼科杂志, 2011, 11(8):1364-1368.
3. 曹葭, 姚勇, 傅东红, 等.无锡市50岁及以上人群年龄相关性黄斑变性流行病学调查[J].中国实用眼科杂志, 2013, 31(4):494-498.
4. 黄晓波, 邹海东, 王宁, 等.上海市北新泾街道老年人年龄相关性黄斑变性的患病率调查[J].上海交通大学学报(医学版), 2012, 32(2):155-159.
5. 邹海东, 张晳, 许迅, 等.上海市静安区曹家渡街道年龄相关性黄斑变性的患病率调查[J].中华眼科杂志, 2005, 4(1):15-19.
6. Seddon JM, Sharma S, Adelman RA, et al. Evaluation of the clinical age-related maculopathy staging system[J].Ophthalmology, 2006, 113(2):260-266.
7. Khan JC, Thurlby DA, Shahid H, et al. Somking and age related macular degeneration:the number of pack years of cigarette smoking is a major determinat of risk for both geographic atrophy and ehoroidal neovascularisaton[J]. Br J Ophthalmol, 2006, 90(1): 75-80.
8. Mützell S. Brain damage in alcoholics without neuropshychological impairment: a populationg study[J]. Ups J Med Sci, 1991, 96(2):129-140.
9. 李武靓, 李慧平, 李娜, 等.宁夏农村地区60岁以上人群年龄相关性黄斑变性的患病率调查[J].宁夏医学杂志, 2015, 37(2):125-128.
10. Velilla S, García-Medina JJ, García-Layana A, et al.Smoking and age-related macular degeneration: review and update. J Ophthalmol, 2013, 2013:895147.http://dx. Doi. org/10.1155/2013/895147.
11. Lechanteur YT, van de Camp PL, Smailhodzic D, et al. Association of smoking and CFH and ARMS2 risk variants with younger age at onset of neovascular age-related macular degeneration[J].JAMA Ophthalmol, 2015, 133(5):533-541.
12. Jonas JB, Xu L.Smoking and age-related macular degeneration[J].Arch Ophthalmol, 2009, 127(6):826-827.
13. Erke MG, Bertelsen G, Peto T, et al. Prevalence of age-related macular degeneration in elderly Caucasians: the Tromso Eye Study[J].Ophthalmology, 2012, 119(9):1737-1743.
14. Choudhury F, Varma R, McKean-Cowdin R, et al.Risk factors for four-year incidence and progression of age-related macular degeneration: the Los Angeles Latino Eye study[J].Am J Ophthalmol, 2011, 152(3):385-395.
15. Clemons TE, Milton RC, Klein R, et al.Risk factors for the incidence of advanced age-related macular degeneration in the Age-Related Eye Disease Study (AREDS) AREDS report no. 19[J]. Ophthalmology, 2005, 112(4):533-539.

Chinese Journal of Ocular Fundus Diseases

The prevalence of age-related macular degeneration in the rural area of Qidong County, Jangsu Province

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