光相干断层扫描血管成像技术及其在眼底相关疾病中的应用_Chinese Journal of Ocular Fundus Diseases

Authors：

王林妮 ,  李志清 , 李筱荣

300384 天津医科大学眼科医院天津医科大学眼科研究所天津医科大学眼视光学院;

Corresponding author：

李志清, Email: lzhqyk@163.com

Keywords：

视网膜血管; 体层摄影术, 光学相干/利用; 眼疾病/诊断; 综述

DOI：

10.3760/cma.j.issn.1005-1015.2015.05.026

Video：

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光相干断层扫描(OCT)血管成像技术(OCTA)是一种快速、无创的新型血管成像技术。可实现视网膜脉络膜血管分层成像, 量化病灶血流面积和指定区域血流指数；同时避免了眼底血管造影等有创检查的潜在风险。应用于视网膜血管性疾病、脉络膜新生血管、特发性黄斑中心凹旁毛细血管扩张症及视神经炎等眼底疾病的诊断和治疗随访, 在分层显示视网膜各层血管及其血流状态方面表现出独具特色的优势。但OCTA扫描范围有限、对患者配合度要求较高；对视网膜血管屏障功能的观察较为有限。随着OCTA扫描速度提高和扫描范围扩大, 联合常规横断面OCT等辅助检查, 有望克服OCTA使用过程中发现的这些不足, 拓展OCTA在眼底疾病中的应用范围, 从而加深对视网膜循环及其相关疾病的认识。

Citation： 王林妮, 李志清, 李筱荣. 光相干断层扫描血管成像技术及其在眼底相关疾病中的应用. Chinese Journal of Ocular Fundus Diseases, 2015, 31(5): 495-497. doi: 10.3760/cma.j.issn.1005-1015.2015.05.026 Copy

1.	Jia Y, Bailey ST, Hwang TS, et al. Quantitative optical coherence tomography angiography of vascular abnormalities in the living human eye[J]. Proc Natl Acad Sci USA, 2015, 112(18):2395-2402.
2.	de Carlo TE, Bonini Filho MA, Chin AT, et al. Spectral-domain optical coherence tomography angiography of choroidal neovascularization[J]. Ophthalmology, 2015, 122(6):1228-1238.
3.	Schwartz DM, Fingler J, Kim DY, et al. Phase-variance optical coherence tomography: a technique for noninvasive angiography[J]. Ophthalmology, 2014, 121(1):180-187.
4.	Kim DY, Fingler J, Werner JS, et al. In vivo volumetric imaging of human retinal circulation withphase-variance optical coherence tomography[J]. Biomed Opt Express, 2011, 2(6):1504-1513.
5.	Kim DY, Fingler J, Zawadzki RJ, et al. Noninvasive imaging of the foveal avascular zone withhigh-speed, phase-variance optical coherence tomography[J]. Invest Ophthalmol Vis Sci, 2012, 53(1):85-92.
6.	Leitgeb RA, Schmetterer L, Hitzenberger CK, et al. Real-time measurement of in vitro flow by Fourier-domain color Doppler optical coherence tomography[J]. Opt Lett, 2004, 29(2):171-173.
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11.	Jia Y, Tan O, Tokayer J, et al. Split-spectrum amplitude-decorrelation angiography with optical coherence tomography[J]. Opt Express, 2012, 20(4):4710-4725.
12.	Wangsa-Wirawan ND, Linsenmeier RA. Retinal oxygen: fundamental and clinical aspects[J]. Arch Ophthalmol, 2003, 121(4):547-557.
13.	Kwiterovich KA, Maguire MG, Murphy RP, et al. Frequency of adverse systemic reactions after fluorescein angiography: results of a prospective study[J]. Ophthalmology, 1991, 98(7):1139-1142.
14.	Ha SO, Kim DY, Sohn CH, et al. Anaphylaxis caused by intravenous fluorescein: clinical characteristics and review of literature[J]. Intern Emerg Med, 2014, 9(3):325-330.
15.	Matsunaga D, Yi J, Puliafito CA, et al. OCT angiography in healthy human subjects[J]. Ophthalmic Surg Lasers Imaging Retina, 2014, 45(6):510-515.
16.	Xu J, Han S, Balaratnasingam C, et al. Retinal angiography with real-time speckle variance optical coherence tomography. Br J Ophthalmol, 2015. http://bjo.bmj.com/content/early/2015/03/02/bjophthalmol-2014-306010.long.[published online ahead of print].
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18.	Spaide RF, Klancnik JM Jr, Cooney MJ. Retinal vascular layers imaged by fluorescein angiography and optical coherence tomography angiography[J]. JAMA Ophthalmol, 2015, 133(1):45-50.
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20.	Kuehlewein L, An L, Durbin MK, et al. Imaging areas of retinal nonperfusion in ischemic branch retinal vein occlusion with swept-source OCT microangiography[J]. Ophthalmic Surg Lasers Imaging Retina, 2015, 46(2):249-252.
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24.	Jia Y, Bailey ST, Wilson DJ, et al. Quantitative optical coherence tomography angiography of choroidal neovascularization in age-related macular degeneration[J]. Ophthalmology, 2014, 121(7):1435-4144.
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26.	Bonini Filho MA, de Carlo TE, Ferrara D, et al. Association of choroidal neovascularization and central serous chorioretinopathy with optical coherence tomography angiography[J]. JAMA Ophthalmol, 2015, 133(8):899-906.
27.	Dansingani KK, Naysan J, Freund KB. En face OCT angiography demonstrates flow in early type 3 neovascularization (retinal angiomatous proliferation) [J]. Eye (Lond), 2015, 29(5):703-706.
28.	Spaide RF. Optical coherence tomography angiography signs of vascular abnormalization with antiangiogenic therapy for choroidal neovascularization[J]. Am J Ophthalmol, 2015, 160(1):6-16.
29.	Yannuzzi LA. Macular telangiectasia type 2[M]//Yannuzzi LA. The retinal atlas. Philadelphia: Saunders Elsevier, 2010:422.
30.	Thorell MR, Zhang Q, Huang Y, et al. Swept-source OCT angiography of macular telangiectasia type 2[J]. Ophthalmic Surg Lasers Imaging Retina, 2014, 45(5):369-380.
31.	Spaide RF, Klancnik JM Jr, Cooney MJ. Retinal vascular layers in macular telangiectasia type 2 imaged by optical coherence tomographic angiography[J]. JAMA Ophthalmol, 2015, 133(1):66-73.
32.	Jia Y, Wei E, Wang X, et al. Optical coherence tomography angiography of optic disc perfusion in glaucoma[J]. Ophthalmology, 2014, 121(7):1322-1332.
33.	Percy AK, Nobrega FT, Kurland LT. Optic neuritis and multiple sclerosis: an epidemiologic study[J]. Arch Ophthalmol, 1972, 87(2):135-139.
34.	Wang X, Jia Y, Spain R, et al. Optical coherence tomography angiography of optic nerve head and parafovea in multiple sclerosis[J]. Br J Ophthalmol, 2014, 98(10):1368-1373.

1. Jia Y, Bailey ST, Hwang TS, et al. Quantitative optical coherence tomography angiography of vascular abnormalities in the living human eye[J]. Proc Natl Acad Sci USA, 2015, 112(18):2395-2402.
2. de Carlo TE, Bonini Filho MA, Chin AT, et al. Spectral-domain optical coherence tomography angiography of choroidal neovascularization[J]. Ophthalmology, 2015, 122(6):1228-1238.
3. Schwartz DM, Fingler J, Kim DY, et al. Phase-variance optical coherence tomography: a technique for noninvasive angiography[J]. Ophthalmology, 2014, 121(1):180-187.
4. Kim DY, Fingler J, Werner JS, et al. In vivo volumetric imaging of human retinal circulation withphase-variance optical coherence tomography[J]. Biomed Opt Express, 2011, 2(6):1504-1513.
5. Kim DY, Fingler J, Zawadzki RJ, et al. Noninvasive imaging of the foveal avascular zone withhigh-speed, phase-variance optical coherence tomography[J]. Invest Ophthalmol Vis Sci, 2012, 53(1):85-92.
6. Leitgeb RA, Schmetterer L, Hitzenberger CK, et al. Real-time measurement of in vitro flow by Fourier-domain color Doppler optical coherence tomography[J]. Opt Lett, 2004, 29(2):171-173.
7. Tao YK, Kennedy KM, Izatt JA. Velocity-resolved 3D retinal microvessel imaging using singleflow imaging spectral domain optical coherence tomography[J]. Opt Express, 2009, 17(5):4177-4188.
8. Liu X, Kirby M, Zhao F. Motion analysis and removal in intensity variation based OCT angiography[J]. Biomed Opt Express, 2014, 5(11):3833-3847.
9. Nam AS, Chico-Calero I, Vakoc BJ. Complex differential variance algorithm for optical coherence tomography angiography[J]. Biomed Opt Express, 2014, 5(11):3822-3832.
10. Drexler W, Liu M, Kumar A, et al. Optical coherence tomography today: speed, contrast, and multimodality. J Biomed Opt, 2014, 19(7):071412.http://biomedicaloptics.spiedigitallibrary.org/article.aspx?articleid=1893809.
11. Jia Y, Tan O, Tokayer J, et al. Split-spectrum amplitude-decorrelation angiography with optical coherence tomography[J]. Opt Express, 2012, 20(4):4710-4725.
12. Wangsa-Wirawan ND, Linsenmeier RA. Retinal oxygen: fundamental and clinical aspects[J]. Arch Ophthalmol, 2003, 121(4):547-557.
13. Kwiterovich KA, Maguire MG, Murphy RP, et al. Frequency of adverse systemic reactions after fluorescein angiography: results of a prospective study[J]. Ophthalmology, 1991, 98(7):1139-1142.
14. Ha SO, Kim DY, Sohn CH, et al. Anaphylaxis caused by intravenous fluorescein: clinical characteristics and review of literature[J]. Intern Emerg Med, 2014, 9(3):325-330.
15. Matsunaga D, Yi J, Puliafito CA, et al. OCT angiography in healthy human subjects[J]. Ophthalmic Surg Lasers Imaging Retina, 2014, 45(6):510-515.
16. Xu J, Han S, Balaratnasingam C, et al. Retinal angiography with real-time speckle variance optical coherence tomography. Br J Ophthalmol, 2015. http://bjo.bmj.com/content/early/2015/03/02/bjophthalmol-2014-306010.long.[published online ahead of print].
17. Mendis KR, Balaratnasingam C, Yu P, et al.Correlation of histologic and clinical images to determine the diagnostic value of fluorescein angiography for studying retinal capillary detail[J]. Invest Ophthalmol Vis Sci, 2010, 51(11):5864-5869.
18. Spaide RF, Klancnik JM Jr, Cooney MJ. Retinal vascular layers imaged by fluorescein angiography and optical coherence tomography angiography[J]. JAMA Ophthalmol, 2015, 133(1):45-50.
19. Ishibazawa A, Nagaoka T, Takahashi A, et al. Optical coherence tomography angiography in diabetic retinopathy: a prospective pilot study[J]. Am J Ophthalmol, 2015, 160(1):35-44.
20. Kuehlewein L, An L, Durbin MK, et al. Imaging areas of retinal nonperfusion in ischemic branch retinal vein occlusion with swept-source OCT microangiography[J]. Ophthalmic Surg Lasers Imaging Retina, 2015, 46(2):249-252.
21. Ikuno Y, Tano Y. Retinal and choroidal biometry in highly myopic eyes with spectral-domain optical coherence tomography[J]. Invest Ophthalmol Vis Sci, 2009, 50(8): 3876-3880.
22. Ikuno Y, Jo Y, Hamasaki T, et al. Ocular risk factors for choroidal neovascularization in pathologic myopia[J]. Invest Ophthalmol Vis Sci, 2010, 51(7): 3721-3725.
23. Hong YJ, Miura M, Makita S, et al. Noninvasive investigation of deep vascular pathologies of exudative macular diseases by high-penetration optical coherence angiography[J]. Invest Ophthalmol Vis Sci, 2013, 54(5):3621-3631.
24. Jia Y, Bailey ST, Wilson DJ, et al. Quantitative optical coherence tomography angiography of choroidal neovascularization in age-related macular degeneration[J]. Ophthalmology, 2014, 121(7):1435-4144.
25. Moult E, Choi W, Waheed NK, et al. Ultrahigh-speed swept-source OCT angiography in exudative AMD[J]. Ophthalmic Surg Lasers Imaging Retina, 2014, 45(6):496-505.
26. Bonini Filho MA, de Carlo TE, Ferrara D, et al. Association of choroidal neovascularization and central serous chorioretinopathy with optical coherence tomography angiography[J]. JAMA Ophthalmol, 2015, 133(8):899-906.
27. Dansingani KK, Naysan J, Freund KB. En face OCT angiography demonstrates flow in early type 3 neovascularization (retinal angiomatous proliferation) [J]. Eye (Lond), 2015, 29(5):703-706.
28. Spaide RF. Optical coherence tomography angiography signs of vascular abnormalization with antiangiogenic therapy for choroidal neovascularization[J]. Am J Ophthalmol, 2015, 160(1):6-16.
29. Yannuzzi LA. Macular telangiectasia type 2[M]//Yannuzzi LA. The retinal atlas. Philadelphia: Saunders Elsevier, 2010:422.
30. Thorell MR, Zhang Q, Huang Y, et al. Swept-source OCT angiography of macular telangiectasia type 2[J]. Ophthalmic Surg Lasers Imaging Retina, 2014, 45(5):369-380.
31. Spaide RF, Klancnik JM Jr, Cooney MJ. Retinal vascular layers in macular telangiectasia type 2 imaged by optical coherence tomographic angiography[J]. JAMA Ophthalmol, 2015, 133(1):66-73.
32. Jia Y, Wei E, Wang X, et al. Optical coherence tomography angiography of optic disc perfusion in glaucoma[J]. Ophthalmology, 2014, 121(7):1322-1332.
33. Percy AK, Nobrega FT, Kurland LT. Optic neuritis and multiple sclerosis: an epidemiologic study[J]. Arch Ophthalmol, 1972, 87(2):135-139.
34. Wang X, Jia Y, Spain R, et al. Optical coherence tomography angiography of optic nerve head and parafovea in multiple sclerosis[J]. Br J Ophthalmol, 2014, 98(10):1368-1373.

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Chinese Journal of Ocular Fundus Diseases

光相干断层扫描血管成像技术及其在眼底相关疾病中的应用

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