Pay attention to the research hotspots and evidence quality for the diagnosis and treatment of non-arteritic anterior ischemic optic neuropathy_Chinese Journal of Ocular Fundus Diseases

Authors：

 ZhongYong , ChenTing

Department of Ophthalmology, Chinese Academy of Medical Sciences & Peking Union Medical College, Peking Union Medical College Hospital, Beijing 100730, China;

Corresponding author：

ZhongYong, Email: yzhong_eye@163.com

Keywords：

Optic neuropathy, ischemic/etiology; Risk factors

DOI：

10.3760/cma.j.issn.1005-1015.2015.06.002

Video：

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Non-arteritic anterior ischemic optic neuropathy (NAION) is one of the most common acute optic neuropathy in adult characterized with impaired visual acuity and visual fields. The pathogenesis of NAION mostly result from the interactions between the systemic risk factors (such as diabetes mellitus, night hypotension, hereditary) and the local ocular risk factors (such as small optic disc and vitreo-papillary traction). A fully promoted diagnosis and treatment of NAION are based on the higher levels of clinical evidence, as well as the comprehensive assessment of relationship between the systemic and ocular risk factors in the pathogenesis of NAION. Secondary optic neuropathy of NAION and the early diagnosis with effective treatment of the fellow eye would be highly emphasized.

Citation： ZhongYong, ChenTing. Pay attention to the research hotspots and evidence quality for the diagnosis and treatment of non-arteritic anterior ischemic optic neuropathy. Chinese Journal of Ocular Fundus Diseases, 2015, 31(6): 521-523. doi: 10.3760/cma.j.issn.1005-1015.2015.06.002 Copy

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2.	Miller NR, Arnold AC. Current concepts in the diagnosis, pathogenesis and management of nonarteritic anterior ischaemic optic neuropathy[J]. Eye (Lond), 2015, 29(1):65-79.
3.	Ciulla TA, Harris A, Latkany P, et al. Ocular perfusion abnormalities in diabetes[J]. Acta Ophthalmol Scand, 2002, 80(5):468-477.
4.	Arnold AC. Pathogenesis of nonarteritic anterior ischemic optic neuropathy[J]. J Neuroophthalmol, 2003, 23(2):157-163.
5.	Chen T, Song D, Shan G, et al. The association between diabetes mellitus and nonarteritic anterior ischemic optic neuropathy: a systematic review and meta-analysis[J/OL].PLoS One, 2013, 8(9):76653[2013-09-30].http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3786911/..
6.	Ciulla TA, Amador AG, Zinman B. Diabetic retinopathy and diabetic macular edema: pathophysiology, screening, and novel therapies[J]. Diabetes Care, 2003, 26(9):2653-2664.
7.	Miyamoto K, Ogura Y. Pathogenetic potential of leukocytes in diabetic retinopathy[J]. Semin Ophthalmol, 1999, 14(4):233-239.
8.	Slagle WS, Musick AN, Eckermann D R. Diabetic papillopathy and its relation to optic nerve ischemia[J]. Optom Vis Sci, 2009, 86:395-403.
9.	Glueck CJ, Fontaine RN, Wang P. Interaction of heritable and estrogen-induced thrombophilia: possible etiologies for ischemic optic neuropathy and ischemic stroke[J].Thromb Haemost, 2001, 85(2):256-259.
10.	Wan W, Peng T, Jin X, et al. Glutathione-S-transferase deletions and non-arteritic anterior ischemic optic neuropathy[J/OL]. Mol Neurobiol, 2015[2015-05-20]. http://download.springer.com/static/pdf/20/art%253A10.1007%252Fs12035-015-9185-3.pdf?originUrl=http%3A%2F%2Flink.springer.com%2Farticle%2F10.1007%2Fs12035-015-9185-3 & token2=exp=1447376091~acl=%2Fstatic%2Fpdf%2F20%2Fart%25253A10.1007%25252Fs12035-015-9185-3.pdf%3ForiginUrl%3Dhttp%253A%252F%252Flink.springer.com%252Farticle%252F10.1007%252Fs12035-015-9185-3*~hmac=ef645d299a5827a6f3cc906ecd413adefa8c9ca2267b46d4b1291e78164c9af3.. [published onlie ahead of pint 20 May 2015].
11.	Sakai T, Shikishima K, Matsushima M, et al. Genetic polymorphisms associated with endothelial function in nonarteritic anterior ischemic optic neuropathy[J]. Mol Vis, 2013, 19:213-219.
12.	Markoula S, Giannopoulos S, Asproudis I, et al. Renin-angiotensin-aldosterone system genes and nonarteritic anterior ischemic optic neuropathy[J]. Mol Vis, 2011, 17:1254-1260.
13.	Burde RM.Optic disk risk factors for nonarteritic anterior ischemic optic neuropathy[J]. 1993, 116(6):759-764.
14.	Beck RW, Servais GE, Hayreh SS. Anterior ischemic optic neuropathy.Ⅸ. Cup-to-disc ratio and its role in pathogenesis[J]. Ophthalmology, 1987, 94(11):1503-1508.
15.	Parsa CF, Hoyt WF. Nonarteritic anterior ischemic optic neuropathy (NAION): a misnomer. Rearranging pieces of a puzzle to reveal a nonischemic papillopathy caused by vitreous separation[J]. Ophthalmology, 2015, 122(3):439-442.
16.	Maekubo T, Chuman H, Kodama Y, et al. Evaluation of inner retinal thickness around the optic disc using optical coherence tomography of a rodent model of nonarteritic ischemic optic neuropathy[J]. Jpn J Ophthalmol, 201357(3): 327-332.
17.	Christoph K, Flemming B. Assessment of functional and morphometric endpont in patients with non-arteritic anterior ischemic optic neuropathy (NAION)[J]. Graefe's Arch Clin Exp Ophthalmol, 2014252(3):515-521.
18.	Touitou V, Johnson MA, Guo Y, et al.Sustained neuroprotection from a single intravitreal injection of PGJ2 in a rodent model of anterior ischemic optic neuropathy[J]. Invest Ophthalmol Vis Sci, 2013.54(12):7402-7409.
19.	Chuman H, Maekubo T, Osako T, et al. Effects of L-arginine on anatomical and electrophysiological deterioration of the eye in a rodent model of nonarteritic ischemic optic neuropathy[J]. Jpn J Ophthalmol, 2013. 57(4): 402-409.
20.	Goldenberg-Cohen N, Dadon-Bar-El S, Hasanreisoglu M, et al.Possible neuroprotective effect of brimonidine in a mouse model of ischaemic optic neuropathy[J]. Clin Experiment Ophthalmol, 2009.37(7): 718-729.
21.	Michael KM, Yan G. Ciliary neurotrophic factor(CNTF)-mediated ganglion cell survival in a rodent model of non-arteritic anterior ischaemic optic neuropathy (NAION)[J]. Br J Ophthalmol, 2015, 99(1):133-137.
22.	Fard MA, Ebrahimi KB, Miller NR. RhoA activity and post-ischemic inflammation in an experimental model of adult rodent anterior ischemic optic neuropathy[J]. Brain Res, 2013, 1534:76-86.
23.	Ahmed Z, Kalinski H, Berry M, et al. Ocular neuroprotection by siRNA targeting capase-2[J/OL]. Cell Death Dis, 2011, 2: e173. http://www.researchgate.net/publication/51223438_Ocular_neuroprotection_by_siRNA_targeting_caspase-2.. [published online 16 June 2011].
24.	Di Polo A, Aigner LJ. Prolonged delivery of brain-derived neurotrophic factor by adenovirus-infected Muller cells temporarily rescues injured retinal ganglion cells[J]. Proc Natl Acad Sci USA, 1998, 95(7):3978-3983.

1. Hayreh SS. Ischemic optic neuropathy[J]. Prog Retin Eye Re, 2009, 28(1):34-62.
2. Miller NR, Arnold AC. Current concepts in the diagnosis, pathogenesis and management of nonarteritic anterior ischaemic optic neuropathy[J]. Eye (Lond), 2015, 29(1):65-79.
3. Ciulla TA, Harris A, Latkany P, et al. Ocular perfusion abnormalities in diabetes[J]. Acta Ophthalmol Scand, 2002, 80(5):468-477.
4. Arnold AC. Pathogenesis of nonarteritic anterior ischemic optic neuropathy[J]. J Neuroophthalmol, 2003, 23(2):157-163.
5. Chen T, Song D, Shan G, et al. The association between diabetes mellitus and nonarteritic anterior ischemic optic neuropathy: a systematic review and meta-analysis[J/OL].PLoS One, 2013, 8(9):76653[2013-09-30].http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3786911/..
6. Ciulla TA, Amador AG, Zinman B. Diabetic retinopathy and diabetic macular edema: pathophysiology, screening, and novel therapies[J]. Diabetes Care, 2003, 26(9):2653-2664.
7. Miyamoto K, Ogura Y. Pathogenetic potential of leukocytes in diabetic retinopathy[J]. Semin Ophthalmol, 1999, 14(4):233-239.
8. Slagle WS, Musick AN, Eckermann D R. Diabetic papillopathy and its relation to optic nerve ischemia[J]. Optom Vis Sci, 2009, 86:395-403.
9. Glueck CJ, Fontaine RN, Wang P. Interaction of heritable and estrogen-induced thrombophilia: possible etiologies for ischemic optic neuropathy and ischemic stroke[J].Thromb Haemost, 2001, 85(2):256-259.
10. Wan W, Peng T, Jin X, et al. Glutathione-S-transferase deletions and non-arteritic anterior ischemic optic neuropathy[J/OL]. Mol Neurobiol, 2015[2015-05-20]. http://download.springer.com/static/pdf/20/art%253A10.1007%252Fs12035-015-9185-3.pdf?originUrl=http%3A%2F%2Flink.springer.com%2Farticle%2F10.1007%2Fs12035-015-9185-3 & token2=exp=1447376091~acl=%2Fstatic%2Fpdf%2F20%2Fart%25253A10.1007%25252Fs12035-015-9185-3.pdf%3ForiginUrl%3Dhttp%253A%252F%252Flink.springer.com%252Farticle%252F10.1007%252Fs12035-015-9185-3*~hmac=ef645d299a5827a6f3cc906ecd413adefa8c9ca2267b46d4b1291e78164c9af3.. [published onlie ahead of pint 20 May 2015].
11. Sakai T, Shikishima K, Matsushima M, et al. Genetic polymorphisms associated with endothelial function in nonarteritic anterior ischemic optic neuropathy[J]. Mol Vis, 2013, 19:213-219.
12. Markoula S, Giannopoulos S, Asproudis I, et al. Renin-angiotensin-aldosterone system genes and nonarteritic anterior ischemic optic neuropathy[J]. Mol Vis, 2011, 17:1254-1260.
13. Burde RM.Optic disk risk factors for nonarteritic anterior ischemic optic neuropathy[J]. 1993, 116(6):759-764.
14. Beck RW, Servais GE, Hayreh SS. Anterior ischemic optic neuropathy.Ⅸ. Cup-to-disc ratio and its role in pathogenesis[J]. Ophthalmology, 1987, 94(11):1503-1508.
15. Parsa CF, Hoyt WF. Nonarteritic anterior ischemic optic neuropathy (NAION): a misnomer. Rearranging pieces of a puzzle to reveal a nonischemic papillopathy caused by vitreous separation[J]. Ophthalmology, 2015, 122(3):439-442.
16. Maekubo T, Chuman H, Kodama Y, et al. Evaluation of inner retinal thickness around the optic disc using optical coherence tomography of a rodent model of nonarteritic ischemic optic neuropathy[J]. Jpn J Ophthalmol, 201357(3): 327-332.
17. Christoph K, Flemming B. Assessment of functional and morphometric endpont in patients with non-arteritic anterior ischemic optic neuropathy (NAION)[J]. Graefe's Arch Clin Exp Ophthalmol, 2014252(3):515-521.
18. Touitou V, Johnson MA, Guo Y, et al.Sustained neuroprotection from a single intravitreal injection of PGJ2 in a rodent model of anterior ischemic optic neuropathy[J]. Invest Ophthalmol Vis Sci, 2013.54(12):7402-7409.
19. Chuman H, Maekubo T, Osako T, et al. Effects of L-arginine on anatomical and electrophysiological deterioration of the eye in a rodent model of nonarteritic ischemic optic neuropathy[J]. Jpn J Ophthalmol, 2013. 57(4): 402-409.
20. Goldenberg-Cohen N, Dadon-Bar-El S, Hasanreisoglu M, et al.Possible neuroprotective effect of brimonidine in a mouse model of ischaemic optic neuropathy[J]. Clin Experiment Ophthalmol, 2009.37(7): 718-729.
21. Michael KM, Yan G. Ciliary neurotrophic factor(CNTF)-mediated ganglion cell survival in a rodent model of non-arteritic anterior ischaemic optic neuropathy (NAION)[J]. Br J Ophthalmol, 2015, 99(1):133-137.
22. Fard MA, Ebrahimi KB, Miller NR. RhoA activity and post-ischemic inflammation in an experimental model of adult rodent anterior ischemic optic neuropathy[J]. Brain Res, 2013, 1534:76-86.
23. Ahmed Z, Kalinski H, Berry M, et al. Ocular neuroprotection by siRNA targeting capase-2[J/OL]. Cell Death Dis, 2011, 2: e173. http://www.researchgate.net/publication/51223438_Ocular_neuroprotection_by_siRNA_targeting_caspase-2.. [published online 16 June 2011].
24. Di Polo A, Aigner LJ. Prolonged delivery of brain-derived neurotrophic factor by adenovirus-infected Muller cells temporarily rescues injured retinal ganglion cells[J]. Proc Natl Acad Sci USA, 1998, 95(7):3978-3983.

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Pay attention to the research hotspots and evidence quality for the diagnosis and treatment of non-arteritic anterior ischemic optic neuropathy

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