Objective To observe the characteristics of multifocal eletrotetinogram (mfERG) in nonarteritic anterior ischemic optic neuropathy (NAION) and its relationship with visual acuity and macular central retinal thickness (CRT).
Methods By means of patients self-contrast analysis. 40 patients (40 eyes) with NAION were collected underwent the examinations of best corrected visual acuity, fundus color photography, fundus fluorescein angiography and field of vision. All the disease and normal eyes had underwent the examination of frequency-domain optical coherence tomography (fdOCT) and mfERG. The CRT and retinal thickness about perifovea, parafovea were documented with fdOCT. All patients underwent the retinal macular function exam with mfERG. Centered by macular fovea, the reaction zone were divided into 5 rings from inside to outside by circles, ring 1 0.00°, ring 2 5.44°, ring 3 10.31°, ring 4 16.31°, ring 5 23.42°. Treated ring 1 hexagon as macular center, the amplitude densities of P1 wave, the amplitude of P1 and N1 wave, and the latencies of P1and N1 wave at every ring were observed. The relationship between mfERG characteristics and visual acuity or CRT were analyzed by Spearman correlation analysis.
Results fdOCT revealed that there was significantly statistical difference in the retinal thickness about perifovea between disease eyes and contralateral eyes (P < 0.05). The increase of CRT and retinal thickness about parafovea had no significantly statistical difference between diseases eyes and contralateral eyes (P > 0.05). mfERG revealed that the decrease of amplitude densities about P1 wave at ring 1 to 2 had significantly statistical difference between two groups (P < 0.05); there were no significantly statistical difference in the amplitude densities of P1 wave at ring 3 to 5; the decrease of amplitude about P1 and N1 wave at ring 1 had significantly statistical difference between two groups (P < 0.05). There was no significantly statistical difference in the amplitude of P1 and N1wave at ring 2 to 5, the latencies of P1 and N1 wave at ring 1 to 5 (P > 0.05). The correlation analysis revealed that the amplitude densities and amplitude of P1 wave at ring 1, amplitude of N1 wave at ring 1 had no effect on visual acuity (r=-0.087, 0.195, -0.134; P > 0.05) and CRT(r=-0.154, 0.365, 0.412; P > 0.05).
Conclusions Compared with contralateral eyes, the disease eyes were significantly decrease in amplitude densities of P1 wave at ring 1 to 2, amplitude of P1 and N1 wave at ring 1.There are no correlated between the amplitude densities of P1 wave at ring 1, amplitude of P1 and N1 wave at ring 1 and visual acuity or CRT.
Citation：
GongHongxia, PangYaju, WangLanhui. Characteristics of multifocal eletrotetinogram in nonarteritic anterior ischemic optic neuropathy and its relationship with visual acuity and macular central retinal thickness. Chinese Journal of Ocular Fundus Diseases, 2015, 31(6): 532-535. doi: 10.3760/cma.j.issn.1005-1015.2015.06.005
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Copyright © the editorial department of Chinese Journal of Ocular Fundus Diseases of West China Medical Publisher. All rights reserved
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- 2. Hood DC, Bach M, Brigell M, et al. ISCEV standard for clinical muhifocal electroretinography(2011 edition)[J].Doc Ophthalmol, 2012, 124(1):1-13.
- 3. Miyake Y. Electrodiagnosis of electrodiagnosis of retinal diseases[M]//Miyake Y. Acquired retinal diseases. Tokyo:Springer-Verlag, 2006:181.
- 4. 孔佳慧, 陈松, 王昀, 等.糖尿病患者多焦视网膜电图检测与黄斑区视网膜厚度相关分析[J].中华实用眼科杂志, 2015, 33(2):137-141.
- 5. 陈晶华, 黎晓新.多焦视网膜电图与多焦视诱发电位检测的原理和临床应用[J].中华眼科杂志, 2001, 37(3):167-170.
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