Characteristic of optical coherence tomography image and choroidal thickness in patients with multiple evanescent white dot syndrome_Chinese Journal of Ocular Fundus Diseases

Authors：

 YanShu , DuMin , ShaoLing , 刘钰 , 杨洁 , 周琨

Department of Ophthalmology, Zhengzhou Second Hospital, Zhengzhou 450006, China;

Corresponding author：

YanShu, Email: yanshu8302@126.com

Keywords：

Retinal diseases/diagnosis; Choroid; Macula lutea; Tomography, optical coherence

DOI：

10.3760/cma.j.issn.1005-1015.2015.06.009

Video：

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Objective To observe the characteristic of optical coherence tomography (OCT) and subfoveal choroidal thickness(SFCT) in patients with multiple evanescent white dot syndrome (MEWDS). Methods The clinical data of 10 patients (10 eyes)with MEWDS were included in the study. 10 normal subjects with matched age, gender and ocular refractive status was selected as control. The patients including 9 females (9 eyes) and 1 male (1 eye), with the average age of (27±8) years. The onset time ranged from 5 to 14 days. The patients were in acute phase if it was in 2 weeks after onset, or convalescent phase if onset was 8 weeks ago. The corrected vision, slit lamp biomicroscopy, ophthalmoscope, fundus photography, fundus fluorescein angiography, indocyanine green angiography and optical coherence tomography (OCT) were performed alone or combined in all patients. The SFCT between the acute and convalescent phases were measured using enhanced depth imaging OCT. The average follow-up was 5 months. The OCT characteristics of affected eyes between acute and convalescent phase were compared. The SFCT of the affected eyes and fellow eye were compared. Results The foveal inner segment-outer segment (IS/OS) was disrupted, thin, irregular in the acute phase, and restored in the convalescent phase. The SFCT of patients in the acute phase was (239±140.7) μm, in the convalescent phase was (189.9±115.6) μm. The SFCT in the acute phase was more thicker than the convalescent phase (t=5.287, P < 0.05). The SFCT of fellow eyes in the acute phase was (214.6±127.2) μm, in the convalescent phase was (186.5±108.6) μm, the difference was significant(t=3.553, P < 0.05).The SFCT in the control subject was (155.5±83.5) μm. The SFCT in the acute phase was thicker than the control(Z=-2.117, P < 0.05). Conclusions In the acute phase of MEWDS, the foveal IS/OS was disrupted, thin and irregular in OCT scan. The choroid is thicker in the acute phase than in the convalescent phase in both eyes, and thicker than controls.

Citation： YanShu, DuMin, ShaoLing. Characteristic of optical coherence tomography image and choroidal thickness in patients with multiple evanescent white dot syndrome. Chinese Journal of Ocular Fundus Diseases, 2015, 31(6): 549-552. doi: 10.3760/cma.j.issn.1005-1015.2015.06.009 Copy

1.	Jampol LM, Sieving PA, Pugh D, et al. Multiple evanescent white dot syndrome.Ⅰ. Clinical findings[J]. Arch Ophthalmol, 1984, 102(5): 671-674.
2.	卢宁, 王光璐, 张风, 等.多发性一过性白点综合征的临床观察[J].中华眼底病杂志, 1997, 13 (1): 31-32.
3.	时冀川, 郑曰忠, 王兰惠, 等.多发性一过性白点综合征的临床和眼底血管造影特征[J].中华眼底病杂志, 2011, 27(4):339-341.
4.	李志, 王林丽, 甘润, 等.多发性一过性白点综合征的临床观察[J].国际眼科杂志, 2013, 13(11):2322-2324.
5.	李科军, 刘瑜玲.多发性一过性白点综合征视网膜及脉络膜造影特征分析[J].中国实用眼科杂志, 2013, 31(12):1586-1590.
6.	周才喜.多发性一过性白点综合征眼底吲哚青绿血管造影图像特征意义[J].中国实用眼科杂志, 2013, 31(12):1591-1595.
7.	周才喜, 苑志峰, 刘立民, 等.多发性一过性白点综合征的频域光相干断层扫描检查特征[J].中华眼底病杂志, 2012, 28 (4): 397-399.
8.	陈青山, 吕娟, 李志, 等.多发性一过性白点综合征眼底血管造影特征[J].中华眼底病杂志, 2012, 28 (2): 175-177.
9.	Spaide RF, Koizumi H, Pozzoni MC.Enhanced deplhimaging speetral-domain optical coherence tomngraph[J].Am J Ophthahnol, 2008, 146(4):496-500.
10.	Sikorski BL, Wojtkowski M, Kaluzny JJ, et al.Correlation of spectral optical coherence tomography with fluoreseein andindocyanine green angiography in multiple evanescent white dot syndrome[J].Br J Ophthalmol, 2008, 92(11):1552-1557.
11.	Nguyen MH, Witkin AJ, Reiche IE, et al.Microstructural abnormalities in MEWDS demonstrated by ultrahigh resolution optical coherence tomography[J]. Retina, 2007, 27(4):414-418.
12.	Amin HI.Optical coherence tomography findings in multiple evanescent white dot syndrome[J].Retina, 2006, 26(4):483-484.
13.	Aoyagi R, Hayashi T, Masai A, et al.Subfoveal choroidal thickness in multiple evanescent white dot syndrome[J].Clin Exp Optom, 2012, 95(2):212-217.
14.	Li D, Kishi S. Restored photoreceptor outer segment damage in multiple evanescent white dot syndrome[J].Ophthalmology, 2009, 116(4):762-770.
15.	Aaberg TM, Campo RV, Joffe L.Recurrences and bilaterality in the multiple evanescent white-dot syndrome[J].Am J Ophthalmol, 1985, 100(1):29-37.

1. Jampol LM, Sieving PA, Pugh D, et al. Multiple evanescent white dot syndrome.Ⅰ. Clinical findings[J]. Arch Ophthalmol, 1984, 102(5): 671-674.
2. 卢宁, 王光璐, 张风, 等.多发性一过性白点综合征的临床观察[J].中华眼底病杂志, 1997, 13 (1): 31-32.
3. 时冀川, 郑曰忠, 王兰惠, 等.多发性一过性白点综合征的临床和眼底血管造影特征[J].中华眼底病杂志, 2011, 27(4):339-341.
4. 李志, 王林丽, 甘润, 等.多发性一过性白点综合征的临床观察[J].国际眼科杂志, 2013, 13(11):2322-2324.
5. 李科军, 刘瑜玲.多发性一过性白点综合征视网膜及脉络膜造影特征分析[J].中国实用眼科杂志, 2013, 31(12):1586-1590.
6. 周才喜.多发性一过性白点综合征眼底吲哚青绿血管造影图像特征意义[J].中国实用眼科杂志, 2013, 31(12):1591-1595.
7. 周才喜, 苑志峰, 刘立民, 等.多发性一过性白点综合征的频域光相干断层扫描检查特征[J].中华眼底病杂志, 2012, 28 (4): 397-399.
8. 陈青山, 吕娟, 李志, 等.多发性一过性白点综合征眼底血管造影特征[J].中华眼底病杂志, 2012, 28 (2): 175-177.
9. Spaide RF, Koizumi H, Pozzoni MC.Enhanced deplhimaging speetral-domain optical coherence tomngraph[J].Am J Ophthahnol, 2008, 146(4):496-500.
10. Sikorski BL, Wojtkowski M, Kaluzny JJ, et al.Correlation of spectral optical coherence tomography with fluoreseein andindocyanine green angiography in multiple evanescent white dot syndrome[J].Br J Ophthalmol, 2008, 92(11):1552-1557.
11. Nguyen MH, Witkin AJ, Reiche IE, et al.Microstructural abnormalities in MEWDS demonstrated by ultrahigh resolution optical coherence tomography[J]. Retina, 2007, 27(4):414-418.
12. Amin HI.Optical coherence tomography findings in multiple evanescent white dot syndrome[J].Retina, 2006, 26(4):483-484.
13. Aoyagi R, Hayashi T, Masai A, et al.Subfoveal choroidal thickness in multiple evanescent white dot syndrome[J].Clin Exp Optom, 2012, 95(2):212-217.
14. Li D, Kishi S. Restored photoreceptor outer segment damage in multiple evanescent white dot syndrome[J].Ophthalmology, 2009, 116(4):762-770.
15. Aaberg TM, Campo RV, Joffe L.Recurrences and bilaterality in the multiple evanescent white-dot syndrome[J].Am J Ophthalmol, 1985, 100(1):29-37.

Chinese Journal of Ocular Fundus Diseases

Characteristic of optical coherence tomography image and choroidal thickness in patients with multiple evanescent white dot syndrome

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