The circumpapillary retinal nerve fiber layer thickness and optic disc parameters in retinitis pigmentosa eyes_Chinese Journal of Ocular Fundus Diseases

Authors：

PangYanhua , TanZhi , ZhouZhou ,  ZhaoGuiling , LyuQiurong

Department of Ophthalmology, The Affiliated Hospital of Guangdong Medical College, Zhanjiang 524023, China;

Corresponding author：

ZhaoGuiling, Email: zhaoguiling@qq.com

Keywords：

Retinitis pigmentosa; Optic disk; Nerve fibers; Tomography, optical coherence

DOI：

10.3760/cma.j.issn.1005-1015.2016.01.011

Video：

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Objective To observe the changes of circumpapillary retinal nerve fiber layer (CP-RNFL) thickness and optic disk parameters in retinitis pigmentosa (RP) eyes. Methods Prospective clinical case-control study. A total of 25 patients (42 eyes) with RP were in the RP group, and 42 age matched healthy subjects (84 eyes) in the control group. All subjects underwent optical coherence tomography (OCT) examination, in which 37 eyes with 3D optic disk scanning and 5 eyes with circle optic disk scanning. The parameters included average thickness of entire CP-RNFL, thickness of nasal, superior, temporal and inferior quadrant of CP-RNFL, disc area, disc cup area, rim area, cup/disc (C/D) area ratio, C/D horizontal diameter ratio, C/D vertical diameter ratio, disc cup volume and disc rim volume. Results The average thickness and the thickness of temporal and nasal quadrants of CP-RNFL in RP group were significantly thicker than the control group (t=2.27, 3.73, 6.44; P=0.027, 0.00, 0.00), while the thickness of inferior and superior areas were the same as control group(t=-1.49, -1.19; P=0.14, 0.24). The disc area, disc cup area, C/D area ratio, C/D horizontal diameter ratio, C/D vertical diameter ratio, disc cup volume in RP group were significantly bigger than control group (P < 0.05), while rim area and rim volume were not significant differences (t=1.75, 0.40; P=0.08, 0.59). Conclusion In comparison with the healthy subjects, the average thickness and temporal and nasal areas of CP-RNFL in RP eyes were thicker, and the disc area, disc cup area, C/D area ratio, C/D horizontal diameter ratio, C/D vertical diameter ratio, disc cup volume in RP eyes were bigger.

Citation： PangYanhua, TanZhi, ZhouZhou, ZhaoGuiling, LyuQiurong. The circumpapillary retinal nerve fiber layer thickness and optic disc parameters in retinitis pigmentosa eyes. Chinese Journal of Ocular Fundus Diseases, 2016, 32(1): 44-46. doi: 10.3760/cma.j.issn.1005-1015.2016.01.011 Copy

1.	Van Soest S, Westerveld A, De Jong PT, et al.Retinitis pigmentosa: defined from a molecular point of view[J]. Surv Ophthalmol, 1999, 43(4):321-334.
2.	Wen Y, Klein M, Hood DC. Relationships among multifocal electroretinogram amplitude, visual field sensitivity, and SD-OCT receptor layer thicknesses in patients with retinitis pigmentosa[J]. Invest Ophthalmol Vis Sci, 2012, 53(2):833-840. DOI: 10.1167/iovs.11-8410.
3.	Li ZY, Possin DE, Milam AH. Histopathology of bone spicule pigmentation in retinitis pigmentosa[J].Ophthalmology, 1995, 102(5):805-816.
4.	Anastasakis A, Genead MA, McAnany JJ, et al. Evaluation of retinal nerve fiber layer thickness in patients with retinitis pigmentosa using spectral-domain optical coherence tomography[J]. Retina, 2012, 32(2):358-363.DOI: 10.1097/IAE.0b013e31821a891a.
5.	Xue K, Wang M, Chen J, et al. Retinal nerve fiber layer analysis with scanning laser polarimetry and RTVue-OCT in patients of retinitis pigmentosa[J].Ophthalmologica, 2013, 229(1):38-42.DOI: 10.1159/000337227.
6.	陈彭, 赵明威, 张承芬.视网膜色素变性[M]//张承芬.眼底病学. 2版.北京:人民卫生出版社, 2010:508-520.Cheng P, Zhao MW, Zhang CF. Retinitis pigmentosa[M]//Zhang CF. Diseases of ocular fundus. 2nd ed. Beijing:People's Medical Publishing House, 2010:508-520.
7.	Hood DC, Lin CE, Lazow MA, et al. Thickness of receptor and post-receptor retinal layers in patients with retinitis pigmentosa measured with frequency-domain optical coherence tomography[J]. Invest Ophthalmol Vis Sci, 2009, 50(5):2328-2336. DOI: 10.1167/iovs.08-2936.
8.	Hwang YH, Kim SW, Kim YY, et al.Optic nerve head, retinal nerve fiber layer, and macular thickness measurements in young patients with retinitis pigmentosa[J].Curr Eye Res, 2012, 37(10):914-920. DOI: 10.3109/02713683.2012.688163.
9.	Yildinn MA, Erden B, Teltikoglu M, et al. Analysis of the retinal nerve fiber layer in retinitis pigmentosa using optic coherence tomography.Ophthalmol, 2015, 2015:157365. http://www.hindawi.com/journals/joph/2015/157365/. DOI: 10.1155/2015/157365.
10.	Walia S, Fishman GA. Retinal nerve fiber layer analysis in RP patients using Fourier-domain OCT[J]. Invest Ophthalmol Vis Sci, 2008, 49(8):3525-3528. DOI: 10.1167/iovs.08-1842.
11.	Oishi A, Otani M, Sasahara M, et al. Retinal nerve fiber layer thickness in patients with retinitis pigmentosa[J]. Eye, 2009, 23(3):561-566. DOI: 10.1038/eye.2008.63.
12.	Milam AH, Li ZY, Fariss RN. Histopathology of the human retina in retinitis pigmentosa[J]. Prog Retin Eye Res, 1998, 17(2):175-205.
13.	Huang Q, Chowdhury V, Coroneo MT. Evaluation of patient suitability for a retinal prosthesis using structural and functional tests of inner retinal integrity. Neural Eng, 2009, 6(3):035010. http://stacks.iop.org/1741-2560/6/035010. DOI: 10.1088/1741-2560/6/3/035010.
14.	Knight QJ, Girkin CA, Budenz DL, et al.Effect of race, age, and axial length on optic nerve head parameters and retinal nerve fiber layer thickness measured by Cirrus HD-OCT[J]. Arch Ophthalmol, 2012, 130(3):312-318. DOI: 10.1001/archopthalmol.2011.1576.
15.	赵桂玲, 陈剑, 庞燕华, 等.3D OCT研究近视眼RNFL厚度及视盘参数[J].中国实用眼科杂志, 2014, 32(3):282-285. DOI: 10.3760/cma.j.issn.1006-4443.2014.03.007.Zhao GL, Chen J, Pang YH, et al. Analysis on thickness of retinal nerve fiber layer and optic nerve head parameters in myopia by using optical coherence tomography[J]. Chin J Pract Ophthalmol, 2014, 32(3):282-285. DOI: 10.3760/cma.j.issn.1006-4443.2014.03.007.
16.	Girkin CA, McGwin G Jr, Sinai MJ, et al. Variation in optic nerve and macular structure with age and race with spectral-domain optical coherence tomography[J]. Ophthalmology, 2011, 118(12):2403-2408. DOI: 10.1016/j.ophtha.2011.06.013.

1. Van Soest S, Westerveld A, De Jong PT, et al.Retinitis pigmentosa: defined from a molecular point of view[J]. Surv Ophthalmol, 1999, 43(4):321-334.
2. Wen Y, Klein M, Hood DC. Relationships among multifocal electroretinogram amplitude, visual field sensitivity, and SD-OCT receptor layer thicknesses in patients with retinitis pigmentosa[J]. Invest Ophthalmol Vis Sci, 2012, 53(2):833-840. DOI: 10.1167/iovs.11-8410.
3. Li ZY, Possin DE, Milam AH. Histopathology of bone spicule pigmentation in retinitis pigmentosa[J].Ophthalmology, 1995, 102(5):805-816.
4. Anastasakis A, Genead MA, McAnany JJ, et al. Evaluation of retinal nerve fiber layer thickness in patients with retinitis pigmentosa using spectral-domain optical coherence tomography[J]. Retina, 2012, 32(2):358-363.DOI: 10.1097/IAE.0b013e31821a891a.
5. Xue K, Wang M, Chen J, et al. Retinal nerve fiber layer analysis with scanning laser polarimetry and RTVue-OCT in patients of retinitis pigmentosa[J].Ophthalmologica, 2013, 229(1):38-42.DOI: 10.1159/000337227.
6. 陈彭, 赵明威, 张承芬.视网膜色素变性[M]//张承芬.眼底病学. 2版.北京:人民卫生出版社, 2010:508-520.Cheng P, Zhao MW, Zhang CF. Retinitis pigmentosa[M]//Zhang CF. Diseases of ocular fundus. 2nd ed. Beijing:People's Medical Publishing House, 2010:508-520.
7. Hood DC, Lin CE, Lazow MA, et al. Thickness of receptor and post-receptor retinal layers in patients with retinitis pigmentosa measured with frequency-domain optical coherence tomography[J]. Invest Ophthalmol Vis Sci, 2009, 50(5):2328-2336. DOI: 10.1167/iovs.08-2936.
8. Hwang YH, Kim SW, Kim YY, et al.Optic nerve head, retinal nerve fiber layer, and macular thickness measurements in young patients with retinitis pigmentosa[J].Curr Eye Res, 2012, 37(10):914-920. DOI: 10.3109/02713683.2012.688163.
9. Yildinn MA, Erden B, Teltikoglu M, et al. Analysis of the retinal nerve fiber layer in retinitis pigmentosa using optic coherence tomography.Ophthalmol, 2015, 2015:157365. http://www.hindawi.com/journals/joph/2015/157365/. DOI: 10.1155/2015/157365.
10. Walia S, Fishman GA. Retinal nerve fiber layer analysis in RP patients using Fourier-domain OCT[J]. Invest Ophthalmol Vis Sci, 2008, 49(8):3525-3528. DOI: 10.1167/iovs.08-1842.
11. Oishi A, Otani M, Sasahara M, et al. Retinal nerve fiber layer thickness in patients with retinitis pigmentosa[J]. Eye, 2009, 23(3):561-566. DOI: 10.1038/eye.2008.63.
12. Milam AH, Li ZY, Fariss RN. Histopathology of the human retina in retinitis pigmentosa[J]. Prog Retin Eye Res, 1998, 17(2):175-205.
13. Huang Q, Chowdhury V, Coroneo MT. Evaluation of patient suitability for a retinal prosthesis using structural and functional tests of inner retinal integrity. Neural Eng, 2009, 6(3):035010. http://stacks.iop.org/1741-2560/6/035010. DOI: 10.1088/1741-2560/6/3/035010.
14. Knight QJ, Girkin CA, Budenz DL, et al.Effect of race, age, and axial length on optic nerve head parameters and retinal nerve fiber layer thickness measured by Cirrus HD-OCT[J]. Arch Ophthalmol, 2012, 130(3):312-318. DOI: 10.1001/archopthalmol.2011.1576.
15. 赵桂玲, 陈剑, 庞燕华, 等.3D OCT研究近视眼RNFL厚度及视盘参数[J].中国实用眼科杂志, 2014, 32(3):282-285. DOI: 10.3760/cma.j.issn.1006-4443.2014.03.007.Zhao GL, Chen J, Pang YH, et al. Analysis on thickness of retinal nerve fiber layer and optic nerve head parameters in myopia by using optical coherence tomography[J]. Chin J Pract Ophthalmol, 2014, 32(3):282-285. DOI: 10.3760/cma.j.issn.1006-4443.2014.03.007.
16. Girkin CA, McGwin G Jr, Sinai MJ, et al. Variation in optic nerve and macular structure with age and race with spectral-domain optical coherence tomography[J]. Ophthalmology, 2011, 118(12):2403-2408. DOI: 10.1016/j.ophtha.2011.06.013.

Chinese Journal of Ocular Fundus Diseases

The circumpapillary retinal nerve fiber layer thickness and optic disc parameters in retinitis pigmentosa eyes

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