Oxygen saturation in the retinal vessels of glaucoma and normal eyes_Chinese Journal of Ocular Fundus Diseases

Authors：

WeiLiqing , NieLi , QianZhenbin , ZhaoShixin , XuXiaoqiong , DouRenhui ,  PanWeihua

Eye Hospital of Wenzhou Medical University, Hangzhou 310020, China;

Corresponding author：

PanWeihua, Email: 995969194@qq.com

Keywords：

Glaucoma/etiology; Oximetry

DOI：

10.3760/cma.j.issn.1005-1015.2016.04.015

Video：

Export PDF Favorites Scan Get Citation

Abstract Full text Figures/Tables Video References Cited by

Objective To observe the difference of retinal vessel oxygen saturation in glaucoma and normal eyes. Methods A cross sectional study design was performed. Fifty eyes of 30 glaucoma patients (glaucoma group) and 41 eyes of 27 age-and sex-matched healthy subjects (control group) were included. Retinal vessel oxygen saturation was measured with a spectrophotometric retinal oximeter in darkness and visual fields were obtained by Humphrey filed analyzer. The glaucoma eyes were divided into two groups: mean defect (MD)<6 dB (28 eyes) and MD≥6 dB (22 eyes) according to mean defect of visual field. Results Retinal arteriolar oxygen saturation values in glaucoma group and control group were (94.52±6.51)% and (93.47±6.30)% respectively. No statistical difference was found in retinal oxygen saturation in arterioles (H=-0.949, P=0.343). Retinal venous oxygen saturation values in glaucoma group and control group were (57.57±7.96)% and (52.60±7.70)% respectively. The retinal venous oxygen saturation values in glaucoma group was higher than that in control group (H=-3.318,P=0.001). The retinal arteriovenous difference in glaucoma group and control group were (36.59±4.69)% and (42.41±6.73)% respectively. The retinal arteriovenous difference in glaucoma group was lower than that in control group (H=-4.148,P<0.01). The retinal arteriolar oxygen saturation values in glaucoma eyes with MD<6 dB and MD≥6 dB were (93.38±6.33)% and (95.71±6.54)% respectively, with no statistical difference (H=-1.857,P=0.063). Retinal venous oxygen saturation values in glaucoma eyes with MD<6 dB and MD≥6 dB were (54.83±6.10)% and (61.07±8.79)% respectively. The retinal venous oxygen saturation values in MD≥6 dB glaucoma eyes was higher than that in MD<6 dB glaucoma eyes (H=-2.599, P=0.009). The retinal arteriovenous difference in glaucoma eyes with MD<6 dB and MD≥6 dB were (38.12±4.34)% and (34.64±4.49)% respectively. The retinal arteriovenous difference in MD≥6 dB glaucoma eyes was lower than that in MD<6 dB glaucoma eyes (H=-2.463,P<0.05). Conclusions Compared with healthy eyes, there is no change in the retinal arteriolar oxygen saturation, but the retinal venous oxygen saturation is higher and the retinal arteriovenous difference is lower. This feature is more obvious in MD≥6 dB glaucoma eyes.

Citation： WeiLiqing, NieLi, QianZhenbin, ZhaoShixin, XuXiaoqiong, DouRenhui, PanWeihua. Oxygen saturation in the retinal vessels of glaucoma and normal eyes. Chinese Journal of Ocular Fundus Diseases, 2016, 32(4): 408-412. doi: 10.3760/cma.j.issn.1005-1015.2016.04.015 Copy

1.	Foster PJ, Buhrmann R, Quigley HA, et al. The definition and classification of glaucoma in prevalence surveys[J]. Br J Ophthalmol,2002,86(2):238-242. DOI:10.1136/bjo.86.2.238.
2.	Ramm L, Jentsch S, Peters S, et al. Dependence of diameters and oxygen saturation of retinal vessels on visual field damage and age in primary open-angle glaucoma[J]. Acta Ophthalmol, 2015, 94(3):276-281. DOI:10.1111/aos.12727.
3.	Garh fer G, Fuchsjäger-Mayrl G, Vass C, et al. Retrobulbar blood flow velocities in open angle glaucoma and their association with mean arterial blood pressure[J]. Invest Ophthalmol Vis Sci, 2010, 51(12):6652-6657. DOI:10.1167/iovs.10-5490.
4.	la Cour M, Kiilgaard J, Eysteinsson T, et al. Optic nerve oxygen tension:effects of intraocular pressure and dorzolamide[J]. Br J Ophthalmol, 2000, 84(9):1045-1049. DOI:10.1136/bjo.84.9.1045.
5.	Stefansson E, Pedersen D, Jensen P, et al. Optic nerve oxygenation[J]. Prog Retin Eye Res, 2005, 24(3):307-332. DOI:10.1016/j.preteyeres.2004.09.001.
6.	周文炳,葛坚.青光眼的分类[M]//李凤鸣. 中华眼科学. 北京:人民卫生出版社,2004:1585-1588. Zhou WB,Ge J.Classfication of glaucoma[M]//Li FM. Chinese ophthalmology. Beijing:People's Medical Publishing House, 2004:1585-1588.
7.	陈洁, 蹇文渊,段俊国. 视网膜血氧饱和度测定技术研究及应用进展[J]. 西部医学, 2013, 25(11):1740-1744. DOI:10.3969/j.issn.1672-3511.2013.11052. Chen J, Jian WY, Duan JG. Application progress of retinal oxygen saturation determination[J]. Medical Journal of West China, 2013, 25(11):1740-1744. DOI:10.3969/j.issn.1672-3511.2013.11052.
8.	Tobe LA, Harris A, Schroeder A, et al. Retinal oxygen saturation and metabolism:how does it pertain to glaucoma? An update on the application of retinal oximetry in glaucoma[J]. Eur J Ophthalmol, 2013,23(4):465-472. DOI:10.5301/ejo.5000289.
9.	Michelson G, Scibor M. Intravascular oxygen saturation in retinal vessels in normal subjects and open-angle glaucoma subjects[J]. Acta Ophthalmol Scand, 2006, 84(3):289-295. DOI:10.1111/j.1600-0420.2005.00631.x.
10.	Olafsdottir OB, Vandewalle E, Abegão Pinto L, et al. Retinal oxygen metabolism in healthy subjects and glaucoma patients[J]. Br J Ophthalmol, 2014, 98(3):329-333. DOI:10.1136/bjophthalmol-2013-303162.
11.	Hardarson SH, Gottfredsdottir MS, Halldorsson GH, et al. Glaucoma filtration surgery and retinal oxygen saturation[J]. Invest Ophthalmol Vis Sci, 2009, 50(11):5247-5450. DOI:10.1167/iovs.08-3117.

1. Foster PJ, Buhrmann R, Quigley HA, et al. The definition and classification of glaucoma in prevalence surveys[J]. Br J Ophthalmol,2002,86(2):238-242. DOI:10.1136/bjo.86.2.238.
2. Ramm L, Jentsch S, Peters S, et al. Dependence of diameters and oxygen saturation of retinal vessels on visual field damage and age in primary open-angle glaucoma[J]. Acta Ophthalmol, 2015, 94(3):276-281. DOI:10.1111/aos.12727.
3. Garh fer G, Fuchsjäger-Mayrl G, Vass C, et al. Retrobulbar blood flow velocities in open angle glaucoma and their association with mean arterial blood pressure[J]. Invest Ophthalmol Vis Sci, 2010, 51(12):6652-6657. DOI:10.1167/iovs.10-5490.
4. la Cour M, Kiilgaard J, Eysteinsson T, et al. Optic nerve oxygen tension:effects of intraocular pressure and dorzolamide[J]. Br J Ophthalmol, 2000, 84(9):1045-1049. DOI:10.1136/bjo.84.9.1045.
5. Stefansson E, Pedersen D, Jensen P, et al. Optic nerve oxygenation[J]. Prog Retin Eye Res, 2005, 24(3):307-332. DOI:10.1016/j.preteyeres.2004.09.001.
6. 周文炳,葛坚.青光眼的分类[M]//李凤鸣. 中华眼科学. 北京:人民卫生出版社,2004:1585-1588. Zhou WB,Ge J.Classfication of glaucoma[M]//Li FM. Chinese ophthalmology. Beijing:People's Medical Publishing House, 2004:1585-1588.
7. 陈洁, 蹇文渊,段俊国. 视网膜血氧饱和度测定技术研究及应用进展[J]. 西部医学, 2013, 25(11):1740-1744. DOI:10.3969/j.issn.1672-3511.2013.11052. Chen J, Jian WY, Duan JG. Application progress of retinal oxygen saturation determination[J]. Medical Journal of West China, 2013, 25(11):1740-1744. DOI:10.3969/j.issn.1672-3511.2013.11052.
8. Tobe LA, Harris A, Schroeder A, et al. Retinal oxygen saturation and metabolism:how does it pertain to glaucoma? An update on the application of retinal oximetry in glaucoma[J]. Eur J Ophthalmol, 2013,23(4):465-472. DOI:10.5301/ejo.5000289.
9. Michelson G, Scibor M. Intravascular oxygen saturation in retinal vessels in normal subjects and open-angle glaucoma subjects[J]. Acta Ophthalmol Scand, 2006, 84(3):289-295. DOI:10.1111/j.1600-0420.2005.00631.x.
10. Olafsdottir OB, Vandewalle E, Abegão Pinto L, et al. Retinal oxygen metabolism in healthy subjects and glaucoma patients[J]. Br J Ophthalmol, 2014, 98(3):329-333. DOI:10.1136/bjophthalmol-2013-303162.
11. Hardarson SH, Gottfredsdottir MS, Halldorsson GH, et al. Glaucoma filtration surgery and retinal oxygen saturation[J]. Invest Ophthalmol Vis Sci, 2009, 50(11):5247-5450. DOI:10.1167/iovs.08-3117.

Chinese Journal of Ocular Fundus Diseases

Oxygen saturation in the retinal vessels of glaucoma and normal eyes

Abstract Full text Figures/Tables Video References Cited by

Previous Article

Next Article

Format

Content