The features of optical coherence tomography angiography in acute central serous chorioretinopathy eyes_Chinese Journal of Ocular Fundus Diseases

Authors：

Guo Jingli , Ding Xinyi ,  Wu Haixiang , Zhang Yongjin

Department of Ophthalmology, Eye & ENT Hospital of Fudan University, Shanghai 200031, China;

Corresponding author：

Wu Haixiang, Email: whx577@163.com

Keywords：

Central serous chorioretinopathy; Tomography, optical coherence; Diagnostic imaging

DOI：

10.3760/cma.j.issn.1005-1015.2017.05.013

Video：

Export PDF Favorites Scan Get Citation

Abstract Full text Figures/Tables Video References Cited by

ObjectiveTo observe the alterations of vascular density of superficial or deep retinal vascular plexus and the area of foveal avascular zone (FAZ) in acute central serous chorioretinopathy (CSC) eyes.MethodsThis is a retrospective study including 22 patients with unilateral CSC in acute stages. The patients were divided into group A (22 affected eyes) and B (22 fellow eyes). Twenty eyes of 20 age and gender-matched healthy volunteers (group C) were enrolled in this study. All subjects underwent optical coherence tomography (OCT) angiography examinations. The observation index included signal intensity of blood flow in choroidal capillary, vessel density and FAZ on the superficial capillary plexus (SCP) and deep capillary plexus (DCP).ResultsThe FAZ on DCP in group A was larger than that in group B and C (t=4.28, 5.57; P=0.00、0.00), but there was no significant difference of FAZ on SCP among 3 groups (t=0.28, 0.80; P=0.78, 0.43). The vessel density of SCP and DCP in group A and B were decreased than those in group C (t=−4.40, −2.91; P=0.00, 0.00). The type of choroidal capillaries dilation had two different manifestations by OCTA, which was circumscribed in 12 eyes and diffuse in 10 eyes. The subretinal fluid in macular area which presented dark chamber with weak reflection was observed by en-face OCT.ConclusionsThe vessel density of SCP and DCP in both eyes of acute CSC are lower than those in normal eyes. The FAZ of DCP in affected eyes of acute CSC is larger than that in fellow eyes and normal eyes. The blood flow of dilated choroidal capillary can be manifested as different morphological enhancements.

Citation： Guo Jingli, Ding Xinyi, Wu Haixiang, Zhang Yongjin. The features of optical coherence tomography angiography in acute central serous chorioretinopathy eyes. Chinese Journal of Ocular Fundus Diseases, 2017, 33(5): 494-497. doi: 10.3760/cma.j.issn.1005-1015.2017.05.013 Copy

1.	Levine R, Brucker AJ, Robinson F. Long-term follow-up of idiopathic central serous chorioretinopathy by fluorescein angiography[J]. Ophthalmology,1989,96(6):854-859.
2.	赵明威. 努力探索发病机制,进一步提升治疗水平:中心性浆液性脉络膜视网膜病变研究的现实与挑战[J].中华眼底病杂志,2011,27(4):305-308. DOI:10.3760/cma.j.issn.1005-1015.2011.04.001.Zhao MW.The pathogenesis and the clinical management:the challenges of treatment of central serous chorioretinopathy faced in reality[J].Chin J Ocul Fundus Dis,2011,27(4):305-308.DOI:10.3760/cma.j.issn.1005-1015.2011.04.001.
3.	Daruich A, Matet A, Dirani A, et al. Central serous chorioretinopathy: recent findings and new physiopathology hypothesis[J]. Prog Retin Eye Res,2015,48:82-118.DOI: 10.1016/j.preteyeres.2015.05.003.
4.	Vance SK, Imamura Y, Freund KB. The effects of sildenafil citrate on choroidal thickness as determined by enhanced depth imaging optical coherence tomography[J]. Retina,2011, 31(2): 332- 335.DOI: 10.1097/IAE.0b013e3181eef0ae.
5.	王敏. 利用光相干断层扫描血管成像技术优势,提升视网膜脉络膜血管疾病认知水平[J]. 中华眼底病杂志,2016,32(4):353-356.DOI:10.3760/cma.j.issn.1005-1015.2016.04.003.Wang M.Better understanding retinal and choroidal vascular diseases with optical coherence tomography angiography[J].Chin J Ocul Fundus Dis,2016,32(4):353-356. DOI:10.3760/cma.j.issn.1005-1015.2016.04.003.
6.	El Ameen A, Cohen SY, Semoun O,et al. Type 2 neovascularization secondary to age-related macular degeneration imaged by optical coherence tomography angiography[J]. Retina, 2015, 35(11):2212-2218.DOI: 10.1097/IAE.0000000000000773.
7.	Coscas G, Lupidi M, Coscas F, et al. Optical coherence tomography angiography during follow-up: qualitative and quantitative analysis of mixed type Ⅰand Ⅱchoroidal neovascularization after vascular endothelial growth factor trap therapy[J]. Ophthalmic Res,2015, 54(2):57-63. DOI: 10.1159/000433547.
8.	Ghasemi Falavarjani K, Iafe NA, Hubschman JP, et al. Optical coherence tomography angiography analysis of the foveal avascular zone and macular vessel density after anti-vegf therapy in eyes with diabetic macular edema and retinal vein occlusion[J]. Invest Ophthalmol Vis Sci, 2017, 58(1): 30-34.DOI: 10.1167/iovs.16-20579.
9.	Chen KC, Marsiglia M, Dolz-Marco R, et al. Foveal exudate and choroidal neovascularization in atypical cases of multiple evanescent white dot syndrome[J/OL]. Retina, 2017,2017:E1[2017-01-16].https://insights.ovid.com/pubmed?pmid=28098736. DOI: 10.1097/ IAE.0000000000001486.[published online ahead of print].
10.	Savastano MC, Lumbroso B, Rispoli M. In vivo characterization of retinal vascularization morphology using optical coherence tomography angiography[J]. Retina,2015,35(11):2196-2203. DOI: 10.1097/IAE.0000000000000635.
11.	Chan SY, Wang Q, Wei WB, et al. Optical coherence tomographic angiography in central serous chorioretinopathy[J]. Retina,2016,36(11):2051-2058. DOI: 10.1097/IAE.0000000000001064.
12.	Nelis P,Clemens CR,Alten F,et al. OCT Angiography reveals changes in foveal vessel architecture and foveal flow in central serous chorioretinopathy[J/OL]. Acta Ophthalmol, 2016,2016:E1[2016-11-22].http://onlinelibrary.wiley.com/doi/10.1111/aos.13299/abstract;jsessionid=CF38E27543A3753E3235505C15A577A2.f04t04.DOI:10.1111/aos.13299.[published online ahead of print].

1. Levine R, Brucker AJ, Robinson F. Long-term follow-up of idiopathic central serous chorioretinopathy by fluorescein angiography[J]. Ophthalmology,1989,96(6):854-859.
2. 赵明威. 努力探索发病机制,进一步提升治疗水平:中心性浆液性脉络膜视网膜病变研究的现实与挑战[J].中华眼底病杂志,2011,27(4):305-308. DOI:10.3760/cma.j.issn.1005-1015.2011.04.001.Zhao MW.The pathogenesis and the clinical management:the challenges of treatment of central serous chorioretinopathy faced in reality[J].Chin J Ocul Fundus Dis,2011,27(4):305-308.DOI:10.3760/cma.j.issn.1005-1015.2011.04.001.
3. Daruich A, Matet A, Dirani A, et al. Central serous chorioretinopathy: recent findings and new physiopathology hypothesis[J]. Prog Retin Eye Res,2015,48:82-118.DOI: 10.1016/j.preteyeres.2015.05.003.
4. Vance SK, Imamura Y, Freund KB. The effects of sildenafil citrate on choroidal thickness as determined by enhanced depth imaging optical coherence tomography[J]. Retina,2011, 31(2): 332- 335.DOI: 10.1097/IAE.0b013e3181eef0ae.
5. 王敏. 利用光相干断层扫描血管成像技术优势,提升视网膜脉络膜血管疾病认知水平[J]. 中华眼底病杂志,2016,32(4):353-356.DOI:10.3760/cma.j.issn.1005-1015.2016.04.003.Wang M.Better understanding retinal and choroidal vascular diseases with optical coherence tomography angiography[J].Chin J Ocul Fundus Dis,2016,32(4):353-356. DOI:10.3760/cma.j.issn.1005-1015.2016.04.003.
6. El Ameen A, Cohen SY, Semoun O,et al. Type 2 neovascularization secondary to age-related macular degeneration imaged by optical coherence tomography angiography[J]. Retina, 2015, 35(11):2212-2218.DOI: 10.1097/IAE.0000000000000773.
7. Coscas G, Lupidi M, Coscas F, et al. Optical coherence tomography angiography during follow-up: qualitative and quantitative analysis of mixed type Ⅰand Ⅱchoroidal neovascularization after vascular endothelial growth factor trap therapy[J]. Ophthalmic Res,2015, 54(2):57-63. DOI: 10.1159/000433547.
8. Ghasemi Falavarjani K, Iafe NA, Hubschman JP, et al. Optical coherence tomography angiography analysis of the foveal avascular zone and macular vessel density after anti-vegf therapy in eyes with diabetic macular edema and retinal vein occlusion[J]. Invest Ophthalmol Vis Sci, 2017, 58(1): 30-34.DOI: 10.1167/iovs.16-20579.
9. Chen KC, Marsiglia M, Dolz-Marco R, et al. Foveal exudate and choroidal neovascularization in atypical cases of multiple evanescent white dot syndrome[J/OL]. Retina, 2017,2017:E1[2017-01-16].https://insights.ovid.com/pubmed?pmid=28098736. DOI: 10.1097/ IAE.0000000000001486.[published online ahead of print].
10. Savastano MC, Lumbroso B, Rispoli M. In vivo characterization of retinal vascularization morphology using optical coherence tomography angiography[J]. Retina,2015,35(11):2196-2203. DOI: 10.1097/IAE.0000000000000635.
11. Chan SY, Wang Q, Wei WB, et al. Optical coherence tomographic angiography in central serous chorioretinopathy[J]. Retina,2016,36(11):2051-2058. DOI: 10.1097/IAE.0000000000001064.
12. Nelis P,Clemens CR,Alten F,et al. OCT Angiography reveals changes in foveal vessel architecture and foveal flow in central serous chorioretinopathy[J/OL]. Acta Ophthalmol, 2016,2016:E1[2016-11-22].http://onlinelibrary.wiley.com/doi/10.1111/aos.13299/abstract;jsessionid=CF38E27543A3753E3235505C15A577A2.f04t04.DOI:10.1111/aos.13299.[published online ahead of print].

Chinese Journal of Ocular Fundus Diseases

The features of optical coherence tomography angiography in acute central serous chorioretinopathy eyes

Abstract Full text Figures/Tables Video References Cited by

Previous Article

Next Article

Format

Content