Characteristics of iris vessels exposure and its relevant factors in normal full-term neonates_Chinese Journal of Ocular Fundus Diseases

Authors：

 Chen Wei , Wang Lihua , Feng Jingjing , Tong Huan , Dong Liping , Pu Jianing , Xing Shanshan

Department of Ophthalmology, Beijing Haidian Maternal and Child Health Hospital, Beijing 100080, China;

Corresponding author：

Chen Wei, Email: chenweidgj@163.com

Keywords：

Neonatal screening; Iris/growth & development; Root cause analysis

DOI：

10.3760/cma.j.issn.1005-1015.2017.06.013

Video：

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Objective To observe the rate of iris vessels exposure and analyze its relevant factors in normal full-term neonates. Methods A retrospective study. 1855 normal full term neonates, including 947 boys and 908 girls, were enrolled. The mean gestational age (GA) was (38.84±1.10) weeks and mean birth weight (BW) was (3 396.52±402.08) g. There were 1235 neonates from normal term vaginal delivery, 402 cases of cesarean delivery and 218 cases of forceps delivery. All neonates were examined with hand-held portable slit lamp biomicroscopy within 1 to 3 days after birth by two trained ophthalmologist respectively. Iris vessels exposure was defined as radial red blood vessels along iris fibers. Infants were divided into iris vessels exposure group and iris vessels unexposed group according to the findings of slit lamp biomicroscopy. 78 infants with iris vessels exposure were followed up for 42 days after birth till the iris vessels can’t be seen under microscope. The differences between the two groups were compared for gender, mode of delivery (MOD), GA, BW and body length (BL). Multiple logistic regressions were used to determine the factors related to iris vessels exposure. Results There were 298 neonates with iris vessels exposure among 1855 neonates and the rate was 16.1%. 1557 neonates (83.9%) had unexposed iris vessels. There were no different in gender (χ²=0.551) and MOD (χ²=3.036) between iris vessels exposure group and unexposed group (P>0.05), while the differences in GA (χ²=47.216), BW (t=4.603) and BL (t=3.936) between the two groups were statistically significant (P=0.000). Multiple logistic regression analysis revealed that only GA (β=−0.291, odds ratio=0.747, 95% confidence interval: 0.656 - 0.851, P=0.000) was correlated to iris vessels exposure significantly. The iris vessels couldn’t be seen in 77 of 78 infants with iris vessels exposure when followed up to 42 days. Conclusions The iris vessels exposure in normal full-term neonates is frequently observed. There is a significant inverse correlation between GA and iris vessels exposure.

Citation： Chen Wei, Wang Lihua, Feng Jingjing, Tong Huan, Dong Liping, Pu Jianing, Xing Shanshan. Characteristics of iris vessels exposure and its relevant factors in normal full-term neonates. Chinese Journal of Ocular Fundus Diseases, 2017, 33(6): 609-611. doi: 10.3760/cma.j.issn.1005-1015.2017.06.013 Copy

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1. 赵少贞, 袁佳琴. 裂隙灯活体显微镜检查, 虹膜检查 [M]//李凤鸣, 谢立信. 中华眼科学. 北京: 人民卫生出版社, 2014: 604-605.Zhao SZ, Yuan JQ. Examination of slit lamp biomicroscopy, examination of the iris [M]//Li FM, Xie LX. Chinese ophthalmology. Beijing: People's Medical Publishing House, 2014: 604-605.
2. 朱秀安. 眼球壁, 葡萄膜 [M]//李凤鸣, 谢立信. 中华眼科学. 北京: 人民卫生出版社, 2014: 87-94.Zhu XA. Wall of the eyeball, uvea [M]//Li FM, Xie LX. Chinese ophthalmology. Beijing: People's Medical Publishing House, 2014: 87-94.
3. 李汉林, 周琼. 虹膜新生血管[J]. 江西医药, 2004, 39(6): 448-450. DOI: 10.3760/cma.j.issn.1673-5803.2006.04.018.Li HL, Zhou Q. Iris neovascularization [J]. Jiangxi Medical Journal, 2004, 39(6): 448-450. DOI: 10.3760/cma.j.issn.1673-5803.2006.04.018.
4. 中华医学会眼科学分会眼底病学组. 中国早产儿视网膜病变筛查指南(2014年)[J]. 中华眼科杂志, 2014, 50(12): 933-935. DOI: 10.3760/cma.j.issn.0412-4081.2014.12.017.Chinese Ocular Fundus Diseases Society, Chinese Ophthalmological Society, Chinese Medical Association. Screening guidelines of Chinese retinopathy of prematurity (2014) [J]. Chin J Ophthalmol, 2014, 50(12): 933-935. DOI: 10.3760/cma.j.issn.0412-4081.2014.12.017.
5. 李凤鸣, 黄时洲, 石珍荣. 眼的胚胎发育, 眼的血管系统 [M]//李凤鸣, 谢立信. 中华眼科学. 北京: 人民卫生出版社, 2014: 36-38.Li FM, Huang SZ, Shi ZR. Fetal development of eye, blood vessels of eye [M]//Li FM, Xie LX. Chinese ophthalmology. Beijing: People's Medical Publishing House, 2014: 36-38.
6. Ludwig CA, Callaway NF, Fredrick DR. What colour are newborns' eyes? Prevalence of iris colour in the Newborn Eye Screening Test (NEST) Study [J]. Acta Ophthalmol, 2016, 94(5): 485-488. DOI: 10.1111/aos.13006.
7. Li LH, Li N, Zhao JY, et al. Findings of perinatal ocular examination performed on 3573 healthy full-term newborns [J]. Br J Ophthalmol, 2013, 97(5): 588-591. DOI: 10.1136/bjophthalmol-2012-302539.
8. 王雅从, 耿韶辉, 李艳涛, 等. 新生儿10000例RetCam检查结果分析[J]. 中国眼耳鼻喉科杂志, 2015, 15(5): 348-351. DOI: 10.14166/j.issn.1671-2420.2015.05.012.Wang YC, Geng SH, Li YT, et al. Application of RetCam Ⅲ examination in 10 000 neonates[J]. Chin J Ophthalmol and Otorhinolaryngol, 2015, 15(5): 348-351. DOI: 10.14166/j.issn.1671-2420.2015.05.012.

Chinese Journal of Ocular Fundus Diseases

Characteristics of iris vessels exposure and its relevant factors in normal full-term neonates

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