The correlation between the vitreomacular adhesion and exudative age-related macular degeneration：a meta-analysis_Chinese Journal of Ocular Fundus Diseases

Authors：

Tao Jiwei , Chen Yiqi , Mao Jianbo , Zhang Yun , Zhao Shixin ,  Shen Lijun

Eye Hospital of Wenzhou Medical University, Hangzhou 310020, China;

Corresponding author：

Shen Lijun, Email: slj@mail.eye.ac.cn

Keywords：

Wet macular degeneration/etiology; Vitreous detachment; Meta-analysis

DOI：

10.3760/cma.j.issn.1005-1015.2017.06.017

Video：

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Abstract Full text Figures/Tables Video References Cited by

Objective To investigate the correlation between the vitreomacular adhesion (VMA) and exudative age-related macular degeneration (AMD). Methods A literature research was performed in PubMed, EMbase, Cochrane Library, CNKI and Wanfang database from January 2000 to December 2016. Case-control studies on the relationship between VMA or posterior vitreous detachment and exudative AMD were included in this analysis. Literature screening and data extraction were performed according to inclusion and exclusion criteria. The qualities of the literatures were evaluated according to the Newcastle-Ottawa Scale (NOS). Seven literatures were selected into meta-analysis. The NOS score was 9 points in 1 article, 8 scores in 4 articles, 7 points in 2 articles. A total of 947 eyes with exudative AMD, 638 eyes with dry AMD, and 618 eyes with controls were included. The correlation between exudative AMD and VMA were analyzed using the software Review manager 5.3. Results The prevalence of VMA in exudative AMD eyes was higher than that in controls [odds ratio (OR)=2.14, 95% confidence interval (CI)=1.19 - 3.84, P=0.010] and dry AMD eyes (OR=2.24, 95%CI=1.24 - 4.03, P=0.007). There was no difference in PVD prevalence among exudative AMD eyes, dry AMD eyes (OR=0.44, 95%CI=0.16 - 1.20, P=0.110) and controls (OR=0.70, 95%CI=0.41 - 1.18, P=0.180). Conclusion There is correlation between VMA and exudative AMD.

Citation： Tao Jiwei, Chen Yiqi, Mao Jianbo, Zhang Yun, Zhao Shixin, Shen Lijun. The correlation between the vitreomacular adhesion and exudative age-related macular degeneration：a meta-analysis. Chinese Journal of Ocular Fundus Diseases, 2017, 33(6): 626-630. doi: 10.3760/cma.j.issn.1005-1015.2017.06.017 Copy

1.	Shao J, Choudhary MM, Schachat AP. Neovascular age-related macular degeneration[J]. Dev Ophthalmol, 2016, 55: 125-136. DOI: 10.1159/000438969.
2.	Simpson A, Petrarca R, Jackson TL. Vitreomacular adhesion and neovascular age-related macular degeneration--a review[J]. Surv Opthalmol, 2012, 57(6): 498-509. DOI: 10.1016/j.survophthal.2012.01.011.
3.	Maier M, Pfrommer S, Burzer S, et al. Vitreomacular interface and posterior vitreomacular adhesion in exudative age-related macular degeneration (AMD): an OCT-based comparative study[J]. Klin Monatsbl Augenheilkd, 2012, 229(10): 1030-1035. DOI: 10.1055/s-0032-1315305.
4.	Krebs I, Brannath W, Glittenberg C, et al. Posterior vitreomacular adhesion: a potential risk factor for exudative age-related macular degeneration?[J]. Am J Ophthalmol, 2007, 144(5): 741-746. DOI: 10.1016/j.ajo.2007.07.024.
5.	Robison CD, Krebs I, Binder S, et al. Vitreomacular adhesion in active and end-stage age-related macular degeneration[J]. Am J Ophthalmol, 2009, 148(1): 79-82. DOI: 10.1016/j.ajo.2009.01.014.
6.	Mojana F, Cheng L, Bartsch DU, et al. The role of abnormal vitreomacular adhesion inage-related macular degeneration: spectral optical coherence tomography and surgical results[J]. Am J Ophthalmol, 2008, 146(2): 218-227. DOI: 10.1016/j.ajo.2008.04.027.
7.	Nomura Y, Ueta T, Iriyama A, et al. Vitreomacular interface in typical exudative age-related macular degeneration and polypoidal choroidal vasculopathy[J]. Ophthalmology, 2010, 118(5): 853-859. DOI: 10.1016/j.ophtha.2010.09.001.
8.	Maggio E, Polito A, Guerriero M. Vitreomacular adhesion and the risk of neovascular age-related macular degeneration[J]. Ophthalmology, 2017, 124(5): 657-666. DOI: 10.1016/j.ophtha.2017.01.018.
9.	El-Hifnawy MA, Ibrahim HA, Gomaa AR. The vitreomacular interface in different types of age-related macular degeneration[J]. Int J Ophthalmol, 2017, 10(2): 246-253. DOI: 10.18240/ijo.2017.02.11.
10.	Stefansson E. Microplasmin-induced posterior vitreous detachment affects vitreous oxygen levels[J]. Retina, 2008, 28(8): 1175-1176. DOI: 10.1097/IAE.0b013e318180ab29.
11.	Stefansson E, Geirsdottir A, Sigurdsson H. Metabolic physiology in age related macular degeneration[J]. Prog Retin Eye Res, 2011, 30(1): 72-80. DOI: 10.1016/j.preteyeres.2010.09.003.
12.	Schulze S, Hoerle S, Mennel S, et al. Vitreomacular traction and exudative age-related macular degeneration[J]. Acta Ophthalmol, 2008, 86(5): 470-481. DOI: 10.1111/j.1755-3768.2008.01210.x.
13.	Nussenblatt RB, Ferris F. Age-related macular degeneration and the immune response: implications for therapy[J]. Am J Ophthalmol, 2007, 144(4): 618-626. DOI: 10.1016/j.ajo.2007.06.025.
14.	Donoso LA, Kim D, Frost A, et al. The role of inflammationin the pathogenesis of age-related macular degeneration[J]. Surv Ophthalmol, 2006, 51(2): 137-152. DOI: 10.1016/j.survophthal.2005.12.001.
15.	Wang Y, Wang VM, Chan CC.The role of anti-inflammatory agents in age-related macular degeneration(AMD) treatment[J]. Eye, 2011, 25(2): 127-139. DOI: 10.1038/eye.2010.196.
16.	Beutel J, Luke M, Bartz-Schmidt KU, et al. Vitreal-induced RPE cell traction: investigation of pathological vitreous samples in an invitro contraction model[J]. Ophthalmologe, 2009, 106(10): 893-898. DOI: 10.1007/s00347-008-1847-3.

1. Shao J, Choudhary MM, Schachat AP. Neovascular age-related macular degeneration[J]. Dev Ophthalmol, 2016, 55: 125-136. DOI: 10.1159/000438969.
2. Simpson A, Petrarca R, Jackson TL. Vitreomacular adhesion and neovascular age-related macular degeneration--a review[J]. Surv Opthalmol, 2012, 57(6): 498-509. DOI: 10.1016/j.survophthal.2012.01.011.
3. Maier M, Pfrommer S, Burzer S, et al. Vitreomacular interface and posterior vitreomacular adhesion in exudative age-related macular degeneration (AMD): an OCT-based comparative study[J]. Klin Monatsbl Augenheilkd, 2012, 229(10): 1030-1035. DOI: 10.1055/s-0032-1315305.
4. Krebs I, Brannath W, Glittenberg C, et al. Posterior vitreomacular adhesion: a potential risk factor for exudative age-related macular degeneration?[J]. Am J Ophthalmol, 2007, 144(5): 741-746. DOI: 10.1016/j.ajo.2007.07.024.
5. Robison CD, Krebs I, Binder S, et al. Vitreomacular adhesion in active and end-stage age-related macular degeneration[J]. Am J Ophthalmol, 2009, 148(1): 79-82. DOI: 10.1016/j.ajo.2009.01.014.
6. Mojana F, Cheng L, Bartsch DU, et al. The role of abnormal vitreomacular adhesion inage-related macular degeneration: spectral optical coherence tomography and surgical results[J]. Am J Ophthalmol, 2008, 146(2): 218-227. DOI: 10.1016/j.ajo.2008.04.027.
7. Nomura Y, Ueta T, Iriyama A, et al. Vitreomacular interface in typical exudative age-related macular degeneration and polypoidal choroidal vasculopathy[J]. Ophthalmology, 2010, 118(5): 853-859. DOI: 10.1016/j.ophtha.2010.09.001.
8. Maggio E, Polito A, Guerriero M. Vitreomacular adhesion and the risk of neovascular age-related macular degeneration[J]. Ophthalmology, 2017, 124(5): 657-666. DOI: 10.1016/j.ophtha.2017.01.018.
9. El-Hifnawy MA, Ibrahim HA, Gomaa AR. The vitreomacular interface in different types of age-related macular degeneration[J]. Int J Ophthalmol, 2017, 10(2): 246-253. DOI: 10.18240/ijo.2017.02.11.
10. Stefansson E. Microplasmin-induced posterior vitreous detachment affects vitreous oxygen levels[J]. Retina, 2008, 28(8): 1175-1176. DOI: 10.1097/IAE.0b013e318180ab29.
11. Stefansson E, Geirsdottir A, Sigurdsson H. Metabolic physiology in age related macular degeneration[J]. Prog Retin Eye Res, 2011, 30(1): 72-80. DOI: 10.1016/j.preteyeres.2010.09.003.
12. Schulze S, Hoerle S, Mennel S, et al. Vitreomacular traction and exudative age-related macular degeneration[J]. Acta Ophthalmol, 2008, 86(5): 470-481. DOI: 10.1111/j.1755-3768.2008.01210.x.
13. Nussenblatt RB, Ferris F. Age-related macular degeneration and the immune response: implications for therapy[J]. Am J Ophthalmol, 2007, 144(4): 618-626. DOI: 10.1016/j.ajo.2007.06.025.
14. Donoso LA, Kim D, Frost A, et al. The role of inflammationin the pathogenesis of age-related macular degeneration[J]. Surv Ophthalmol, 2006, 51(2): 137-152. DOI: 10.1016/j.survophthal.2005.12.001.
15. Wang Y, Wang VM, Chan CC.The role of anti-inflammatory agents in age-related macular degeneration(AMD) treatment[J]. Eye, 2011, 25(2): 127-139. DOI: 10.1038/eye.2010.196.
16. Beutel J, Luke M, Bartz-Schmidt KU, et al. Vitreal-induced RPE cell traction: investigation of pathological vitreous samples in an invitro contraction model[J]. Ophthalmologe, 2009, 106(10): 893-898. DOI: 10.1007/s00347-008-1847-3.

Chinese Journal of Ocular Fundus Diseases

The correlation between the vitreomacular adhesion and exudative age-related macular degeneration：a meta-analysis

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