The changes of macular choroidal thickness in patients with mild to moderate Alzheimer’s disease_Chinese Journal of Ocular Fundus Diseases

Authors：

Bao Jing ,  Lyu Zhigang , Zhang Xiangxiang , Ye Danni

Department of Ophthalmology, Jinhua Central Hospital, Jinhua 321000, China;

Corresponding author：

Lyu Zhigang, Email: jhyylzg@163.com

Keywords：

Alzheimer's disease; Tomography, optical coherence; Choroidal thickness

DOI：

10.3760/cma.j.issn.1005-1015.2019.03.004

Video：

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Objective To obverse the changes of macular choroidal thickness (CT) in patients with mild to moderate Alzheimer’s disease (AD).Methods This was a case-control study. Twenty-one patients with mild to moderate AD confirmed by Neurology Department of Jinhua Central Hospital from November 2016 to June 2018 and 21 age-matched control subjects were concluded in the study. There was no significant difference in age (t=0.128), intraocular pressure (t=0.440) and axial length (t=1.202) between the two groups (P＞0.05). There was significant difference in mini-mental state examination score (t=8.608, P＜0.05). CT was measured by OCT with enhanced depth imaging technique in the subfoveal choroid, at 0.5 mm and 1.0 mm from the center of the fovea nasal (NCT_{0.5, 1.0 mm}), temporal (TCT_{0.5, 1.0 mm}), superior (SCT_{0.5, 1 .0 mm}), and inferior (ICT_{0.5, 1.0 mm}). Independent-samples t test was used to compare the results obtained from these two groups.Results SFCT (t=2.431), NCT_{0.5, 1.0 mm} (t=3.341, 2.640), TCT_{0.5, 1.0 mm} (t=3.340, 2.899), SCT_{0.5, 1.0 mm} (t=3.576, 3.751) and ICT_{0.5, 1.0 mm} (t=2.897, 2.903) were significantly thinner in AD eyes than those in control eyes.Conclusion Compared with healthy subjects, patients with mild to moderate AD showed a significant reduction in CT.

Citation： Bao Jing, Lyu Zhigang, Zhang Xiangxiang, Ye Danni. The changes of macular choroidal thickness in patients with mild to moderate Alzheimer’s disease. Chinese Journal of Ocular Fundus Diseases, 2019, 35(3): 231-234. doi: 10.3760/cma.j.issn.1005-1015.2019.03.004 Copy

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11.	Trebbastoni A, Marcelli M, Mallone F, et al. Attenuation of choroidal thickness in patients with alzheimer disease: evidence from an Italian prospective study[J]. Alzheimer Dis Assoc Disord, 2017, 31(2): 128-134. DOI: 10.1097/WAD.0000000000000176.
12.	Bulut M, Yaman A, Erol MK, et al. Choroidal thickness in patients with mild cognitive impairment and Alzheimer's type dementia[J/OL]. J Ophthalmol, 2016, 2016: 7291257[2016-01-11]. http://dx.doi.org/10.1155/2016/7291257. DOI: 10.1155/2016/7291257.
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14.	Barteselli G, Chhablani J, El-Emam S, et al. Choroidal volume variations with age, axial length, and sex in healthy subjects: a three-dimensional analysis[J]. Ophthalmology, 2012, 119(12): 2572-2578. DOI: 10.1016/j.ophtha.2012.06.065.
15.	Usui S, Ikuno Y, Akiba M, et al. Circadian changes in subfoveal choroidal thickness and the relationship with circulatory factors in healthy subjects[J]. Invest Ophthalmol Vis Sci, 2012, 53(4): 2300-2307. DOI: 10.1167/iovs.11-8383.
16.	Ding X, Li J, Zeng J, et al. Choroidal thickness in healthy Chinese subjects[J]. Invest Ophthalmol Vis Sci, 2011, 52(13): 9555-9560. DOI: 10.1167/iovs.11-8076.
17.	李略, 杨治坤, 董方田. 应用增强深部成像的相干光断层扫描测量正常人脉络膜厚度[J]. 中华眼科杂志, 2012, 48(9): 819-823. DOI: 10.3760/cma.j.issn.0412-4081.2012.09.012.Li L, Yang ZK, Dong FT. Choroidal thickness in normal subjects measured by enhanced depth imaging optical coherence tomography[J]. Chin J Ophthalmol, 2012, 48(9): 819-823. DOI: 10.3760/cma.j.issn.0412-4081.2012.09.012.

1. Dehabadi MH, Davis BM, Wong TK, et al. Retinal manifestations of Alzheimer’s disease[J]. Neurodegener Dis Manag, 2014, 4(3): 241-252. DOI: 10.2217/nmt.14.19.
2. Niall P, Tariq A, Thomas M, et al. Retinal vascular image analysis as a potential screening tool for cerebrovascular disease: a rationale based on homology between cerebral and retinal microvasculatures[J]. J Anat, 2005, 206(4): 319-348. DOI: 10.1111/j.1469-7580.2005.00395.x.
3. Tsai Y, Lu B, Ljubimov AV, et al. Ocular changes in TgF344-AD rat model of Alzheimer's disease[J]. Invest Ophthalmol Vis Sci, 2014, 55(1): 523-534. DOI: 10.1167/iovs.13-12888.
4. Gharbiya M, Trebbastoni A, Parisi F, et al. Choroidal thinning as a new finding in Alzheimer's disease: evidence from enhanced depth imaging spectral domain optical coherence tomography[J]. J Alzheimers Dis, 2014, 40(4): 907-917. DOI: 10.3233/JAD-132039.
5. Cunha JP, Proença R, Dias-Santos A, et al. Choroidal thinning: Alzheimer's disease and aging[J]. Alzheimers Dement (Amst), 2017, 8: 11-17. DOI: 10.1016/j.dadm.2017.03.004.
6. McKhann G, Drachman D, Folstein M, et al. Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease[J]. Neurology, 1984, 34(7): 939-944. DOI: 10.1212/WNL.34.7.939.
7. Wang B, Niu Y, Miao L, et al. Decreased complexity in alzheimer's disease: resting-state fmri evidence of brain entropy mapping[J]. Front Aging Neurosci, 2017, 9: 378. DOI: 10.3389/fnagi.2017.00378.
8. Du LY, Chang LY, Ardiles AO, et al. Alzheimer's disease-related protein expression in the retina of octodon degus[J/OL]. PLoS One, 2015, 10(8): 0135499[2015-08-12]. https://doi.org/10.1371/journal.pone.0135499. DOI: 10.1371/journal.pone.0135499.
9. Frost S, Kanagasingam Y, Sohrabi H, et al. Retinal vascular biomarkers for early detection and monitoring of Alzheimer’s disease[J]. Transl. Psychiatry, 2013, 3: 233. DOI: 10.1038/tp.2012.150.
10. Cunha JP, Moura-Coelho N, Proença RP, et al. Alzheimer’s disease: a review of its visual system neuropathology. Optical coherence tomography-a potential role as a study tool in vivo[J]. Graefe’s Arch Clin Exp Ophthalmol, 2016, 254(11): 2079-2092. DOI: 10.1007/s00417-016-3430-y.
11. Trebbastoni A, Marcelli M, Mallone F, et al. Attenuation of choroidal thickness in patients with alzheimer disease: evidence from an Italian prospective study[J]. Alzheimer Dis Assoc Disord, 2017, 31(2): 128-134. DOI: 10.1097/WAD.0000000000000176.
12. Bulut M, Yaman A, Erol MK, et al. Choroidal thickness in patients with mild cognitive impairment and Alzheimer's type dementia[J/OL]. J Ophthalmol, 2016, 2016: 7291257[2016-01-11]. http://dx.doi.org/10.1155/2016/7291257. DOI: 10.1155/2016/7291257.
13. Bayhan HA, Aslan Bayhan S, Celikbilek A, et al. Evaluation of the chorioretinal thickness changes in Alzheimer's disease using spectral-domain optical coherence tomography[J]. Clin Exp Ophthalmol, 2015, 43(2): 145-151. DOI: 10.1111/ceo.12386.
14. Barteselli G, Chhablani J, El-Emam S, et al. Choroidal volume variations with age, axial length, and sex in healthy subjects: a three-dimensional analysis[J]. Ophthalmology, 2012, 119(12): 2572-2578. DOI: 10.1016/j.ophtha.2012.06.065.
15. Usui S, Ikuno Y, Akiba M, et al. Circadian changes in subfoveal choroidal thickness and the relationship with circulatory factors in healthy subjects[J]. Invest Ophthalmol Vis Sci, 2012, 53(4): 2300-2307. DOI: 10.1167/iovs.11-8383.
16. Ding X, Li J, Zeng J, et al. Choroidal thickness in healthy Chinese subjects[J]. Invest Ophthalmol Vis Sci, 2011, 52(13): 9555-9560. DOI: 10.1167/iovs.11-8076.
17. 李略, 杨治坤, 董方田. 应用增强深部成像的相干光断层扫描测量正常人脉络膜厚度[J]. 中华眼科杂志, 2012, 48(9): 819-823. DOI: 10.3760/cma.j.issn.0412-4081.2012.09.012.Li L, Yang ZK, Dong FT. Choroidal thickness in normal subjects measured by enhanced depth imaging optical coherence tomography[J]. Chin J Ophthalmol, 2012, 48(9): 819-823. DOI: 10.3760/cma.j.issn.0412-4081.2012.09.012.

Chinese Journal of Ocular Fundus Diseases

The changes of macular choroidal thickness in patients with mild to moderate Alzheimer’s disease

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