Advances in the Application of Smart Phones in Modern Medicine_Journal of Biomedical Engineering

Authors：

WANGLin ^1,2 , HUJie ^1,2 , LIFei ^2,3 , WEIHuilin ⁴ , LIYing ⁵ , LUTianjian ² , WANGShuqi ⁶ ,  XUFeng ^1,2

1. The Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an 710049, China;
2. Bioinspired Engineering and Biomechanics Center, Xi'an Jiaotong University, Xi'an 710049, China;
3. Department of Applied Chemistry, School of Science, Xi'an Jiaotong University, Xi'an 710049, China;
4. Lauren Biotechnology Ltd., Nanjing 210019, China;
5. School of Electronic Engineering, Xidian University, Xi'an 710126, China;
6. Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02139, U. S. A;

Corresponding author：

XUFeng, Email: fengxu@mail.xjtu.edu.cn

Keywords：

Smart phone; Modern medicine; Applications; Advances; Point-of-care testing (POCT)

DOI：

10.7507/1001-5515.20140042

Video：

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Since smart phones have been developed, significant advances in the function of mobile phone due to the development of software, hardware and accessories have been reached. Till now, smart phones have been engaged in daily life with an increasing impact. As a new medical model, mobile phone medicine is emerging and has found widespread applications in medicine, especially in diagnosing, monitoring and screening various diseases. In addition, mobile phone medical application shows great potential trend to improve healthcare in resource-limited regions due to its advantageous features of portability and information communication capability. Nowadays, the scientific and technological issues related to mobile phone medicine have attracted worldwide attention. In this review, we summarize state-of-the-art advances of mobile phone medicine with focus on its diagnostics applications in order to expand the fields of their applications and promote healthcare informatization.

Citation： WANGLin, HUJie, LIFei, WEIHuilin, LIYing, LUTianjian, WANGShuqi, XUFeng. Advances in the Application of Smart Phones in Modern Medicine. Journal of Biomedical Engineering, 2014, 31(1): 222-227. doi: 10.7507/1001-5515.20140042 Copy

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2.	张晓丁,刘静.基于手机的远程可视化医学技术研究[J].中国医疗器械信息,2010,16(10):28-33,79.
3.	WANG H, LIU J. Mobile phone based health care technology[J]. Recent Pat Biomed Eng, 2009, 2(1):15-21.
4.	XIE Q M, LIU J. Mobile phone based biomedical imaging technology:a newly emerging area[J]. Recent Pat Biomed Eng, 2010, 3(1):41-53.
5.	黄硕,刘静.手机与计算机之间的图像无线交互传输技术及其医学应用[J].中国医疗器械杂志,2010,34(3):167-171.
6.	LIU L, LIU J. Biomedical sensor technologies on the platform of mobile phones[J]. Front Mech Eng, 2011, 6(2):160-175.
7.	GRANOT Y, IVORRA A, RUBINSKY B. A new concept for medical imaging centered on cellular phone technology[J]. PLoS One, 2008, 3(4):e2075.
8.	ZUROVAC D, AO T A, SNOW R W. Mobile phone text messaging:tool for malaria control in Africa[J]. PLoS Med, 2012, 9(2):e1001176.
9.	王昊,刘静.睡眠障碍的手机监测方法研究[J].北京生物医学工程,2010,29(3):270-277.
10.	COXWORTH B. Face-scanning cameras could pick out drunks[EB/OL]. (2012-09-04)[2012-10-04]. http://www.gizmag.com/drunk-face-scanning-cameras/23993/.
11.	唐艳,汤井田.应用移动通讯技术设计心电监护系统[J].生物医学工程学杂志,2006,23(5):1130-1133.
12.	WONG P. EPI Life:World's first EKG mobile phone[EB/OL]. (2010-06-16)[2012-10-04]. http://news.cnet.com/8301-17938_105-20007953-1.html?part=rssamp;amp;subj=newsamp;amp;tag=2547-1_3-0-20.
13.	ROBERTSON A. New imaging system could let cellphones see through walls[EB/OL]. (2012-04-18)[2012-10-04]. http://www.theverge.com/2012/4/18/2957280/imaging-chip-research-ut-dallas-cell-phone-x-ray-vision.
14.	ISO T, KAWASAKI N, KURAKAKE S. Personal context extractor with multiple sensors on a cell phone[C/OL]. The Seventh IFIP International Conference on Mobile and Wireless Communications Networks (MWCN 2005), Marrakech, Morocco, September 19-21, 2005. (2005-09-21)[2012-10-04]. http://www.ctr.kcl.ac.uk/MWCN2005/Paper/C200525.pdf.
15.	SCULLY C G, LEE J, MEYER J, et al. Physiological parameter monitoring from optical recordings with a mobile phone[J]. IEEE Trans Biomed Eng, 2012, 59(2):303-306.
16.	刘琳,刘静.手机助老助残技术的研究与进展[J].中国医疗器械信息,2011,17(1):6-15.
17.	SMITH Z J, CHU K, ESPENSON A R, et al. Cell-phone-based platform for biomedical device development and education applications[J]. PLoS One, 2011, 6(3):e17150.
18.	FITZPATRICK T. Ultrasound imaging now possible with a smartphone[EB/OL]. (20090-4-20)[2012-10-04]. http://news.wustl.edu/news/pages/13928.aspx.
19.	BALAN E. HealthPia GlucoPhone, with Blood Glucose Meter[EB/OL]. (20070-8-14)[2012-10-04]. http://news.softpedia.com/news/HealthPia-GlucoPhone-with-Blood-Glucose-Meter-62664.shtml.
20.	CARROLL A E, MARRERO D G, DOWNS S M. The healthpia glucopack diabetes phone:a usability study[J]. Diabetes Technol Ther, 2007, 9(2):158-164.
21.	CARROLL A E, DIMEGLIO L A, STEIN S, et al. Using a cell phone-based glucose monitoring system for adolescent diabetes management[J]. Diabetes Educ, 2011, 37(1):59-66.
22.	MACMANUS C, KATZ L. Android phones get heart-healthy[EB/OL]. (2010-10-14)[2012-10-04]. http://news.cnet.com/8301-17938_105-20019684-1.html.
23.	IWAMOTO J, OGAWA H, MAKI H, et al. A mobile phone-based ecg and heart sound monitoring system-biomed 2011[J]. Biomed Sci Instrum, 2011, 47:160-164.
24.	EHMEN H, HAESNER M, STEINKE I, et al. Comparison of four different mobile devices for measuring heart rate and ECG with respect to aspects of usability and acceptance by older people[J]. Appl Ergon, 2012, 43(3):582-587.
25.	王海滨,江钟伟,董秀成,等.基于听诊器的心音采集解析系统[J].生物医学工程学杂志,2009,26(2):282-287.
26.	李建银.基于智能手机平台的心音采集和无线传输技术的研究[D].南京:南京邮电大学,2011.
27.	SUTHERLAND K. StethoCloud promises a low-cost solution to pneumonia diagnoses[EB/OL].(2012-09-04)[2012-10-04]. http://www.gizmag.com/stethoscope-stethocloud-app/23999/.
28.	BRESLAUER D N, MAAMARI R N, SWITZ N A, et al. Mobile phone based clinical microscopy for global health applications[J]. PLoS One, 2009, 4(7):e6320.
29.	ZHU H, MAVANDADI S, COSKUN A F, et al. Optofluidic fluorescent imaging cytometry on a cell phone[J]. Anal Chem, 2011, 83(17):6641-6647.
30.	UCLA Office of Intellectual Property & Industry Sponsored Research. A Cell Phone-Based Electrical Biosensor[EB/OL]. (2011)[2012-10-04]. http://techtransfer.universityofcalifornia.edu/NCD/22116.html?utm_source=iBridgeamp;utm_medium=webpageamp;utm_term=ncdid_22116amp;utm_campaign=TechWebsites.
31.	WANG S, ZHAO X, KHIMJI I, et al. Integration of cell phone imaging with microchip elisa to detect ovarian cancer he4 biomarker in urine at the point-of-care[J]. Lab Chip, 2011, 11(20):3411-3418.
32.	MERTZ L. Ultrasound fetal monitoring spectrometer there's an app for that!:biomedical smart phone apps are taking healthcare by storm[J]. IEEE Pulse, 2012, 3(2):16-21.

1. International Telecommunication Union. Key statistical highlights:ITU data release June 2012[EB/OL]. (2012-06)[2012-10-04].http://www.itu.int/ITUD/ict/statistics/material/pdf/2011%20Statistical%20highlights_June_2012.pdf.
2. 张晓丁,刘静.基于手机的远程可视化医学技术研究[J].中国医疗器械信息,2010,16(10):28-33,79.
3. WANG H, LIU J. Mobile phone based health care technology[J]. Recent Pat Biomed Eng, 2009, 2(1):15-21.
4. XIE Q M, LIU J. Mobile phone based biomedical imaging technology:a newly emerging area[J]. Recent Pat Biomed Eng, 2010, 3(1):41-53.
5. 黄硕,刘静.手机与计算机之间的图像无线交互传输技术及其医学应用[J].中国医疗器械杂志,2010,34(3):167-171.
6. LIU L, LIU J. Biomedical sensor technologies on the platform of mobile phones[J]. Front Mech Eng, 2011, 6(2):160-175.
7. GRANOT Y, IVORRA A, RUBINSKY B. A new concept for medical imaging centered on cellular phone technology[J]. PLoS One, 2008, 3(4):e2075.
8. ZUROVAC D, AO T A, SNOW R W. Mobile phone text messaging:tool for malaria control in Africa[J]. PLoS Med, 2012, 9(2):e1001176.
9. 王昊,刘静.睡眠障碍的手机监测方法研究[J].北京生物医学工程,2010,29(3):270-277.
10. COXWORTH B. Face-scanning cameras could pick out drunks[EB/OL]. (2012-09-04)[2012-10-04]. http://www.gizmag.com/drunk-face-scanning-cameras/23993/.
11. 唐艳,汤井田.应用移动通讯技术设计心电监护系统[J].生物医学工程学杂志,2006,23(5):1130-1133.
12. WONG P. EPI Life:World's first EKG mobile phone[EB/OL]. (2010-06-16)[2012-10-04]. http://news.cnet.com/8301-17938_105-20007953-1.html?part=rssamp;amp;subj=newsamp;amp;tag=2547-1_3-0-20.
13. ROBERTSON A. New imaging system could let cellphones see through walls[EB/OL]. (2012-04-18)[2012-10-04]. http://www.theverge.com/2012/4/18/2957280/imaging-chip-research-ut-dallas-cell-phone-x-ray-vision.
14. ISO T, KAWASAKI N, KURAKAKE S. Personal context extractor with multiple sensors on a cell phone[C/OL]. The Seventh IFIP International Conference on Mobile and Wireless Communications Networks (MWCN 2005), Marrakech, Morocco, September 19-21, 2005. (2005-09-21)[2012-10-04]. http://www.ctr.kcl.ac.uk/MWCN2005/Paper/C200525.pdf.
15. SCULLY C G, LEE J, MEYER J, et al. Physiological parameter monitoring from optical recordings with a mobile phone[J]. IEEE Trans Biomed Eng, 2012, 59(2):303-306.
16. 刘琳,刘静.手机助老助残技术的研究与进展[J].中国医疗器械信息,2011,17(1):6-15.
17. SMITH Z J, CHU K, ESPENSON A R, et al. Cell-phone-based platform for biomedical device development and education applications[J]. PLoS One, 2011, 6(3):e17150.
18. FITZPATRICK T. Ultrasound imaging now possible with a smartphone[EB/OL]. (20090-4-20)[2012-10-04]. http://news.wustl.edu/news/pages/13928.aspx.
19. BALAN E. HealthPia GlucoPhone, with Blood Glucose Meter[EB/OL]. (20070-8-14)[2012-10-04]. http://news.softpedia.com/news/HealthPia-GlucoPhone-with-Blood-Glucose-Meter-62664.shtml.
20. CARROLL A E, MARRERO D G, DOWNS S M. The healthpia glucopack diabetes phone:a usability study[J]. Diabetes Technol Ther, 2007, 9(2):158-164.
21. CARROLL A E, DIMEGLIO L A, STEIN S, et al. Using a cell phone-based glucose monitoring system for adolescent diabetes management[J]. Diabetes Educ, 2011, 37(1):59-66.
22. MACMANUS C, KATZ L. Android phones get heart-healthy[EB/OL]. (2010-10-14)[2012-10-04]. http://news.cnet.com/8301-17938_105-20019684-1.html.
23. IWAMOTO J, OGAWA H, MAKI H, et al. A mobile phone-based ecg and heart sound monitoring system-biomed 2011[J]. Biomed Sci Instrum, 2011, 47:160-164.
24. EHMEN H, HAESNER M, STEINKE I, et al. Comparison of four different mobile devices for measuring heart rate and ECG with respect to aspects of usability and acceptance by older people[J]. Appl Ergon, 2012, 43(3):582-587.
25. 王海滨,江钟伟,董秀成,等.基于听诊器的心音采集解析系统[J].生物医学工程学杂志,2009,26(2):282-287.
26. 李建银.基于智能手机平台的心音采集和无线传输技术的研究[D].南京:南京邮电大学,2011.
27. SUTHERLAND K. StethoCloud promises a low-cost solution to pneumonia diagnoses[EB/OL].(2012-09-04)[2012-10-04]. http://www.gizmag.com/stethoscope-stethocloud-app/23999/.
28. BRESLAUER D N, MAAMARI R N, SWITZ N A, et al. Mobile phone based clinical microscopy for global health applications[J]. PLoS One, 2009, 4(7):e6320.
29. ZHU H, MAVANDADI S, COSKUN A F, et al. Optofluidic fluorescent imaging cytometry on a cell phone[J]. Anal Chem, 2011, 83(17):6641-6647.
30. UCLA Office of Intellectual Property & Industry Sponsored Research. A Cell Phone-Based Electrical Biosensor[EB/OL]. (2011)[2012-10-04]. http://techtransfer.universityofcalifornia.edu/NCD/22116.html?utm_source=iBridgeamp;utm_medium=webpageamp;utm_term=ncdid_22116amp;utm_campaign=TechWebsites.
31. WANG S, ZHAO X, KHIMJI I, et al. Integration of cell phone imaging with microchip elisa to detect ovarian cancer he4 biomarker in urine at the point-of-care[J]. Lab Chip, 2011, 11(20):3411-3418.
32. MERTZ L. Ultrasound fetal monitoring spectrometer there's an app for that!:biomedical smart phone apps are taking healthcare by storm[J]. IEEE Pulse, 2012, 3(2):16-21.

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