Application of Silk Fibroin in Biomedical Areas_Journal of Biomedical Engineering

Authors：

JINHuanyu ^1,2 , LIUXing ¹ , YINHua ^2,3 ,  ANYan ^1,2

1. School of Public Health, Medical College of Soochow University, Suzhou 215123, China;
2. National Engineering Laboratory for Modern Silk, Soochow University, Suzhou 215123, China;
3. College of Textile and Clothing Engineering, Soochow University, Suzhou 215006, China;

Corresponding author：

ANYan, Email: dranyan@126.com

Keywords：

silk fibroin; drug carrier; tissue engineering; diabetes care; tumor care

DOI：

10.7507/1001-5515.20140043

Video：

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For a long period of time, silk fibroin has been applied in biomedical areas. Along with the development of biotechnology, new functions of silk fibroin are being found and developed. From the suture of surgery to the therapeutic drug and the ordinary tissue engineering frame to high grade frame with drug buffer system, exploitation of silk fibroin is constantly introduced with something new from the old ones. In our review, we summarize the applications of silk fibroin in tissue engineering, drug buffer system and medical care.

Citation： JINHuanyu, LIUXing, YINHua, ANYan. Application of Silk Fibroin in Biomedical Areas. Journal of Biomedical Engineering, 2014, 31(1): 228-232. doi: 10.7507/1001-5515.20140043 Copy

1.	王琳婷, 朱良均, 闵思佳. 丝素蛋白在生物医学领域的应用研究[J]. 北方蚕业, 2009, 30(3):1-7.
2.	RAMA P, MATUSKA S, PAGANONI G, et al. Limbal stem-cell therapy and long-term corneal regeneration[J]. N Eng J Med, 2010, 363(2):147-155.
3.	BRAY L J, GEORGE K A, AINSCOUGH S L, et al. Human corneal epithelial equivalents constructed on Bombyx mori silk fibroin membranes[J]. Biomaterial, 2011, 32(22):5086-5091.
4.	薛豪杰, 刘琳, 胡丹丹. 低溶胀壳聚糖/丝素蛋白复合膜的制备及性能测试[J]. 蚕业科学, 2011, 37(6):1073-1078.
5.	SERBAN M A, PANILAITIS B, KAPLAN D L. Silk fibroin and polyethylene glycol-based biocompatible tissue adhesives[J]. J Biomed Mater ResA, 2011, 98(4):567-575.
6.	曹阳, 王伯初, 迟少萍. 基于丝素蛋白的药物缓释材料[J]. 中国组织工程研究与临床康复, 2009, 13(8):1533-1536.
7.	WENK E,MERKLE H P,MEINEL L. Silk fibroin as a vehicle for drug delivery applications[J]. J Control Release, 2010, 150(2):128-141.
8.	WENK E,WANDREY A J,MERKLE H P, et al. Silk fibroin spheres as a platform for controlled drug delivery[J]. J Control Release, 2008, 132(1):26-34.
9.	KUNDU J, CHUNG Y I, KIM Y H, et al. Silk fibroin nanoparticles for cellular uptake and control release[J]. Int J Pharm, 2010,388(1-2):242-250.
10.	WANG X, WENK E, MATSUMOTO A, et al. Silk microspheres for encapsulation and controlled release[J]. J Control Release, 2007, 117(3):360-370.
11.	SHI P, GOH J C. Release and cellular acceptance of multiple drugs loaded silk fibroin particles[J]. Int J Pharm, 2011, 420(2):282-289.
12.	孙春光,谢世筠,张芃. 纳米丝素颗粒药物缓释剂的研制及在治疗小鼠溃疡性结肠炎中的药物控制释放作用[J]. 蚕业科学, 2011, 37(4):706-712.
13.	UEBERSAX L,MATTOTTI M, PAPALOÏZOS M, et al. Silk fibroin matrices for the controlled release of nerve growth factor (NGF)[J]. Biomaterials, 2007, 28(30):4449-4460.
14.	WENK E, MURPHY A R, KAPLAN D L, et al. The use of sulfonated silk fibroin derivatives to control binding, delivery and potency of FGF-2 in tissue regeneration[J]. Biomaterial, 2010, 31(6):1403-1413.
15.	WANG X, WENK E, ZHANG X, et al. Growth factor gradients via microsphere delivery in biopolymer scaffolds for osteochondral tissue engineering[J]. J Control Release, 2009, 134(2):81-90.
16.	ZHAO J, ZHANG Z, WANG S, et al. Apatite-coated silk fibroin scaffolds to healing mandibular border defects in canines[J]. Bone, 2009, 45(3):517-527.
17.	JIANG X, ZHAO J, WANG S, et al. Mandibular repair in rats with premineralized silk scaffolds and BMP-2-modified bMSCs[J]. Biomaterial, 2009, 30(27):4522-4532.
18.	黄国平, 陈克平. 家蚕丝素水解物治疗糖尿病的研究进展[J].安徽农业科学, 2010,38(25):13577-13579, 13581.
19.	HYUN C K, KIM I Y, FROST S C. Soluble fibroin enhances insulin sensitivity and glucose metabolism in 3T3-L1 adipocytes[J]. J Nutr,2004, 124(12):3257-3263.
20.	LEE H S, LEE H J, SUH H J. Silk protein hydrolysate increases glucose uptake through up-regulation of GLUT 4 and reduces the expression of leptin in 3T3-L1 fibroblast[J]. Nutr Res, 2011, 31(12):937-943.
21.	PARK K J, SHIN E J, KIM S H, et al. Insulin sensitization of MAP kinase signaling by fibroin in insulin-resistant Hirc-B cells[J]. Pharmacol Res, 2005, 52(4):346-356.
22.	PARK J H, NAM Y, PARK S Y, et al. Silk fibroin has a protective effect against high glucose induced apoptosis in HIT-T15 cells[J]. J Biochem Mol Toxicol, 2011, 25(4):238-243.
23.	BYUN E B, SUNG N Y, KWON S K, et al. In vitro and in vivo studies on the cytotoxicity of irradiated silk fibroin against mouse melanoma tumor cell[J]. Radiation Physics and Chemistry, 2009, 78(7-8):492-431.
24.	BYUN E B, SUNG N Y, KIM J H, et al. Enhancement of anti-tumor activity of gamma-irradiated silk fibroin via immunomodulatory effects[J]. Chem Biol Interact, 2010, 186(1):90-95.
25.	GOBIN A S, RHEA R, NEWMAN R A, et al. Silk-fibroin-coated liposomes for long-term and targeted drug delivery[J]. Int J Nanomedicine, 2006, 1(1):81-87.
26.	CHEEMA S K, GOBIN A S, RHEA R, et al. Silk fibroin mediated delivery of liposomal emodin to breast cancer cells[J]. Int J Pharm, 2007, 341(1-2):221-229.
27.	HOWARD M A, POLO K, PUSIC A L, et al. Breast cancer local recurrence after mastectomy and TRAM flap reconstruction:incidence and treatment options[J]. Plast Reconstr Surg, 2006, 117(5):1381-1386.
28.	GUPTA V, MUN G H, CHOI B, et al. Repair and reconstruction of a resected tumor defect using a composite of tissue flap-nanotherapeutic-silk fibroin and chitosan scaffold[J]. Ann Biomed Eng, 2011, 39(9):2374-2387.

1. 王琳婷, 朱良均, 闵思佳. 丝素蛋白在生物医学领域的应用研究[J]. 北方蚕业, 2009, 30(3):1-7.
2. RAMA P, MATUSKA S, PAGANONI G, et al. Limbal stem-cell therapy and long-term corneal regeneration[J]. N Eng J Med, 2010, 363(2):147-155.
3. BRAY L J, GEORGE K A, AINSCOUGH S L, et al. Human corneal epithelial equivalents constructed on Bombyx mori silk fibroin membranes[J]. Biomaterial, 2011, 32(22):5086-5091.
4. 薛豪杰, 刘琳, 胡丹丹. 低溶胀壳聚糖/丝素蛋白复合膜的制备及性能测试[J]. 蚕业科学, 2011, 37(6):1073-1078.
5. SERBAN M A, PANILAITIS B, KAPLAN D L. Silk fibroin and polyethylene glycol-based biocompatible tissue adhesives[J]. J Biomed Mater ResA, 2011, 98(4):567-575.
6. 曹阳, 王伯初, 迟少萍. 基于丝素蛋白的药物缓释材料[J]. 中国组织工程研究与临床康复, 2009, 13(8):1533-1536.
7. WENK E,MERKLE H P,MEINEL L. Silk fibroin as a vehicle for drug delivery applications[J]. J Control Release, 2010, 150(2):128-141.
8. WENK E,WANDREY A J,MERKLE H P, et al. Silk fibroin spheres as a platform for controlled drug delivery[J]. J Control Release, 2008, 132(1):26-34.
9. KUNDU J, CHUNG Y I, KIM Y H, et al. Silk fibroin nanoparticles for cellular uptake and control release[J]. Int J Pharm, 2010,388(1-2):242-250.
10. WANG X, WENK E, MATSUMOTO A, et al. Silk microspheres for encapsulation and controlled release[J]. J Control Release, 2007, 117(3):360-370.
11. SHI P, GOH J C. Release and cellular acceptance of multiple drugs loaded silk fibroin particles[J]. Int J Pharm, 2011, 420(2):282-289.
12. 孙春光,谢世筠,张芃. 纳米丝素颗粒药物缓释剂的研制及在治疗小鼠溃疡性结肠炎中的药物控制释放作用[J]. 蚕业科学, 2011, 37(4):706-712.
13. UEBERSAX L,MATTOTTI M, PAPALOÏZOS M, et al. Silk fibroin matrices for the controlled release of nerve growth factor (NGF)[J]. Biomaterials, 2007, 28(30):4449-4460.
14. WENK E, MURPHY A R, KAPLAN D L, et al. The use of sulfonated silk fibroin derivatives to control binding, delivery and potency of FGF-2 in tissue regeneration[J]. Biomaterial, 2010, 31(6):1403-1413.
15. WANG X, WENK E, ZHANG X, et al. Growth factor gradients via microsphere delivery in biopolymer scaffolds for osteochondral tissue engineering[J]. J Control Release, 2009, 134(2):81-90.
16. ZHAO J, ZHANG Z, WANG S, et al. Apatite-coated silk fibroin scaffolds to healing mandibular border defects in canines[J]. Bone, 2009, 45(3):517-527.
17. JIANG X, ZHAO J, WANG S, et al. Mandibular repair in rats with premineralized silk scaffolds and BMP-2-modified bMSCs[J]. Biomaterial, 2009, 30(27):4522-4532.
18. 黄国平, 陈克平. 家蚕丝素水解物治疗糖尿病的研究进展[J].安徽农业科学, 2010,38(25):13577-13579, 13581.
19. HYUN C K, KIM I Y, FROST S C. Soluble fibroin enhances insulin sensitivity and glucose metabolism in 3T3-L1 adipocytes[J]. J Nutr,2004, 124(12):3257-3263.
20. LEE H S, LEE H J, SUH H J. Silk protein hydrolysate increases glucose uptake through up-regulation of GLUT 4 and reduces the expression of leptin in 3T3-L1 fibroblast[J]. Nutr Res, 2011, 31(12):937-943.
21. PARK K J, SHIN E J, KIM S H, et al. Insulin sensitization of MAP kinase signaling by fibroin in insulin-resistant Hirc-B cells[J]. Pharmacol Res, 2005, 52(4):346-356.
22. PARK J H, NAM Y, PARK S Y, et al. Silk fibroin has a protective effect against high glucose induced apoptosis in HIT-T15 cells[J]. J Biochem Mol Toxicol, 2011, 25(4):238-243.
23. BYUN E B, SUNG N Y, KWON S K, et al. In vitro and in vivo studies on the cytotoxicity of irradiated silk fibroin against mouse melanoma tumor cell[J]. Radiation Physics and Chemistry, 2009, 78(7-8):492-431.
24. BYUN E B, SUNG N Y, KIM J H, et al. Enhancement of anti-tumor activity of gamma-irradiated silk fibroin via immunomodulatory effects[J]. Chem Biol Interact, 2010, 186(1):90-95.
25. GOBIN A S, RHEA R, NEWMAN R A, et al. Silk-fibroin-coated liposomes for long-term and targeted drug delivery[J]. Int J Nanomedicine, 2006, 1(1):81-87.
26. CHEEMA S K, GOBIN A S, RHEA R, et al. Silk fibroin mediated delivery of liposomal emodin to breast cancer cells[J]. Int J Pharm, 2007, 341(1-2):221-229.
27. HOWARD M A, POLO K, PUSIC A L, et al. Breast cancer local recurrence after mastectomy and TRAM flap reconstruction:incidence and treatment options[J]. Plast Reconstr Surg, 2006, 117(5):1381-1386.
28. GUPTA V, MUN G H, CHOI B, et al. Repair and reconstruction of a resected tumor defect using a composite of tissue flap-nanotherapeutic-silk fibroin and chitosan scaffold[J]. Ann Biomed Eng, 2011, 39(9):2374-2387.

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Application of Silk Fibroin in Biomedical Areas

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