The Progress of Magnetic Nanomaterials in Application of Biomedicine_Journal of Biomedical Engineering

Authors：

TENGAilan , MIDenghai

Department of Pediatrics, The Second Peoples'Hospital of Gansu Province, Lanzhou 730000, China;

Corresponding author：

Keywords：

magnetic nanometer material; nanometer; magnetic resonance

DOI：

10.7507/1001-5515.20140087

Video：

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Magnetic nanomaterials is widely used in medical diagnosis, drug delivery, biomedical and other fields due to their unique structure and excellent properties. The magnetic nanometer material in biomedical applications, such as biological separation and purification, application of controlled drug release and magnetic resonance imaging are reviewed in the present paper, and the development trend of magnetic nanomaterials is also forecasted.

Citation： TENGAilan, MIDenghai. The Progress of Magnetic Nanomaterials in Application of Biomedicine. Journal of Biomedical Engineering, 2014, 31(2): 472-476. doi: 10.7507/1001-5515.20140087 Copy

1.	QIAO R R,YANG C H,GAO M Y.Superparamagnetic iron oxide nanoparticles:from preparations to in vivo MRI applications[J].J Mater Chem,2009,19(35):6274-6293.
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5.	APOSTOLOVA I,WESSELINOWA J M.Composition dependence of the coercivity in magnetic nanoparticles suitable for magnetic hyperthermia[J].Phys Status Solidi B,2009,246(8):1925-1930.
6.	LI F R,YAN W H,GUO Y H,et al.Preparation of carboplatin-Fe@C-loaded chitosan nanoparticles and study on hyperthermia combined with pharmacotherapy for liver cancer[J].Int J Hyperthermia,2009,25(5):383-391.
7.	ZHANG F,WANG C C.Preparation of P (NIPAM-co-AA) microcontainers surface-anchored with magnetic nanoparticles[J].Langmuir,2009,25(14):8255-8262.
8.	BRAZEL C S.Magnetothermally-responsive nanomaterials:combining magnetic nanostructures and thermally-sensitive polymers for triggered drug release[J].Pharm Res,2009,26(3):644-656.
9.	ZHANG X J,JIANG W,LI F S,et al.Controllable preparation of magnetic polymer nanospheres with high saturation magnetization by miniemulsion polymerization[J].Mater Lett,2010,64(2):119-121.
10.	MURALIGANTH T,VADIVEL MURUGAN A,MANTHIRAM A.Facile synthesis of carbon-decorated single-crystalline Fe₃O₄ nanowires and their application as high performance anode in lithium ion batteries[J].Chem Commun (Camb),2009,47:7360-7362.
11.	RICQ L,LALLEMAND F,GIGANDET M P,et al.Influence of sodium saccharin on the electrodeposition and characterization of CoFe magnetic film[J].Surface and Coatings Technology,2001,138(2-3):278-283.
12.	FARAJI M,YAMINI Y,REZAEE M.Magnetic nanoparticles:synthesis,stabilization,functionalization,characterization,and applications[J].J Iran Chem Soc,2010,7(1):1-37.
13.	ZHOU J,MENG L,LU Q,et al.Superparamagnetic submicro-megranates:Fe₃O₄ nanoparticles coated with highly cross-linked organic/inorganic hybrids[J].Chem Commun (Camb),2009,42:6370-6372.
14.	LIANG Y Y,ZHANG L M,JIANG W,et al.Embedding magnetic nanoparticles into polysaccharide-based hydrogels for magnetically assisted bioseparation[J].Chem Phys Chem,2007,8(16):2367-2372.
15.	GUL H,LU W,XU P,et al.Magnetic carbon nanotube labelling for haematopoietic stem/progenitor cell tracking[J].Nanotechnology,2010,21(15):155101.
16.	GUO L,CUI X Z,LI Y S,et al.Hollow mesoporous carbon spheres with magnetic cores and their performance as separable bilirubin adsorbents[J].Chem Asian J,2009,4(9):1480-1485.
17.	KIM Y P,CHO K,LEE D,et al.Efficient enrichment and desalting of protein digests using magnetic mesocellular carbon foams in matrix-assisted laser desorption/ionization mass spectrometry[J].Rapid Commun Mass Spectrom,2007,21(21):3435-3442.
18.	LATHAM A H,WILLIAMS M E.Controlling transport and chemical functionality of magnetic nanoparticles[J].Acc Chem Res,2008,41(3):411-420.
19.	GAO J H,GU H W,XU B.Multifunctional magnetic nanoparticles:design,synthesis,and biomedical applications[J].Acc Chem Res,2009,42(8):1097-1107.
20.	CHEN H M,DENG C H,ZHANG X M.Synthesis of Fe₃O₄@SiO₂@PMMA core-shell-shell magnetic microspheres for highly efficient enrichment of peptides and proteins for MALDI-ToF MS analysis[J].Angew Chem Int Ed Engl,2010,49(3):607-611.
21.	CORCHERO J L,VILLAVERDE A.Biomedical applications of distally controlled magnetic nanoparticles[J].Trends Biotechnol,2009,27(8):468-476.
22.	GUO N,WU D C PAN X H,et al.Magnetic polymer microspheres with azidocarbonyl groups:synthesis,characterization and application in protein immobilization[J].J Appl Polym Sci,2009,112(4):2383-2390.
23.	PENG Z G,HIDAJAT K,UDDIN M S.Conformational change of adsorbed and desorbed bovine serum albumin on nano-sized magnetic particles[J].Colloid Surf B-Biointerfaces,2004,33(1):15-21.
24.	LIN J S,LIN Y S,KUO S T,et al.Purification of α-amylase from human saliva by superparamagnetic particles[J].J Sci Food Agric,2009,89(4):574-578.
25.	LIN J S,LIN Y S,KUO S T,et al.Purification of soybean amylase by superparamagnetic particles[J].Food Chem,2009,117(1):94-98.
26.	SOPACI S B,SIMŞEK I,TURAL B,et al.Carboligation reactions with benzaldehyde lyase immobilized on superparamagnetic solid support[J].Org Biomol Chem,2009,7(8):1658-1664.
27.	DENG Y H,DENG C H,QI D W,et al.Synthesis of core/shell colloidal magnetic zeolite microspheres for the immobilization of trypsin[J].Adv Mater,2009,21(13):1377-1382.
28.	JIN H,LIN J M,WANG X,et al.Magnetic particle-based chemiluminescence enzyme immunoassay for free thyroxine in human serum[J].J Pharm Biomed Anal,2009,50(5):891-896.
29.	LIN H Y,CHEN W Y,CHEN Y C.Iron oxide/tantalum oxide core-shell magnetic nanoparticle-based microwave-assisted extraction for phosphopeptide enrichment from complex samples for MALDI MS analysis[J].Anal Bioanal Chem,2009,394(8):2129-2136.
30.	KRÍZOVÁ J,SPANOVÁ A,RITTICH B,et al.Magnetic hydrophilic methacrylate-based polymer microspheres for genomic DNA isolation[J].J Chromatogr A,2005,1064(2):247-253.
31.	ELAISSARI A.Magnetic latex particles in nanobiotechnologies for biomedical diagnostic applications:state of the art[J].Macromol Symp,2009,281(1):14-19.
32.	ARKHIS A,ELAISSARI A,DELAIR T,et al.Capture of enveloped viruses using polymer tentacles containing magnetic latex particles[J].J Biomed Nanotechnol,2010,6(1):28-36.
33.	GAO J H,XU B.Applications of nanomaterials inside cells[J].Nanotoday,2009,4(1):37-51.
34.	XU Y,KARMAKAR A,WANG D Y,et al.Multifunctional Fe₃O₄ cored magnetic-quantum dot fluorescent nanocomposites for RF nanohyperthermia of cancer cells[J].J Phys Chem C,2010,114(11):5020-5026.
35.	WU C L,HE H,GAO H J,et al.Synthesis of Fe₃O₄@SiO2@polymer nanoparticles for controlled drug release[J].Sci China Chem,2010,53(3):514-518.
36.	XU R,SUN G Y,LI Q Y,et al.A dual-responsive superparamagnetic Fe₃O₄/Silica/PAH/PSS materia used for controlled release of chemmotherapeutic agent,keggin polyoxotungstate,PM-19[J].Solid State Sciences,2010,12(10):1720-1725.
37.	YANG F,LI Y,CHEN Z,et al.Superparamagnetic iron oxide nanoparticle-embedded encapsulated microbubbles as dual contrast agents of magnetic resonance and ultrasound imaging[J].Biomaterials,2009,30(23-24):3882-3890.
38.	TAN H,XUE J M,SHUTER B,et al.Synthesis of PEOlated Fe₃O₄@SiO₂ nanoparticles via bioinspired silification for magnetic resonance imaging[J].Adv Funct Mater,2010,20(5):722-731.
39.	YANG F,JIN C,YANG D,et al.Magnetic functionalised carbon nanotubes as drug vehicles for cancer lymph node metastasis treatment[J].Eur J Cancer,2011,47(12):1873-1882.

1. QIAO R R,YANG C H,GAO M Y.Superparamagnetic iron oxide nanoparticles:from preparations to in vivo MRI applications[J].J Mater Chem,2009,19(35):6274-6293.
2. HUSKA D,HUBALEK J,ADAM V,et al.Automated nucleic acids isolation using paramagnetic microparticles coupled with electrochemical detection[J].Talanta,2009,79(2):402-411.
3. KIM J,LEE J E,LEE S H,et al.Designed fabrication of a multifunctional polymer nanomedical platform for simultaneous cancer-targeted imaging and magnetically guided drug delivery[J].Adv Mater,2008,20(3):478-483.
4. JOSHI H M,LIN Y P,ASLAM M,et al.Effects of shape and size of cobalt ferrite nanostructures on their MRI contrast and thermal activation[J].J Phys Chem C Nanomater Interfaces,2009,113(41):17761-17767.
5. APOSTOLOVA I,WESSELINOWA J M.Composition dependence of the coercivity in magnetic nanoparticles suitable for magnetic hyperthermia[J].Phys Status Solidi B,2009,246(8):1925-1930.
6. LI F R,YAN W H,GUO Y H,et al.Preparation of carboplatin-Fe@C-loaded chitosan nanoparticles and study on hyperthermia combined with pharmacotherapy for liver cancer[J].Int J Hyperthermia,2009,25(5):383-391.
7. ZHANG F,WANG C C.Preparation of P (NIPAM-co-AA) microcontainers surface-anchored with magnetic nanoparticles[J].Langmuir,2009,25(14):8255-8262.
8. BRAZEL C S.Magnetothermally-responsive nanomaterials:combining magnetic nanostructures and thermally-sensitive polymers for triggered drug release[J].Pharm Res,2009,26(3):644-656.
9. ZHANG X J,JIANG W,LI F S,et al.Controllable preparation of magnetic polymer nanospheres with high saturation magnetization by miniemulsion polymerization[J].Mater Lett,2010,64(2):119-121.
10. MURALIGANTH T,VADIVEL MURUGAN A,MANTHIRAM A.Facile synthesis of carbon-decorated single-crystalline Fe₃O₄ nanowires and their application as high performance anode in lithium ion batteries[J].Chem Commun (Camb),2009,47:7360-7362.
11. RICQ L,LALLEMAND F,GIGANDET M P,et al.Influence of sodium saccharin on the electrodeposition and characterization of CoFe magnetic film[J].Surface and Coatings Technology,2001,138(2-3):278-283.
12. FARAJI M,YAMINI Y,REZAEE M.Magnetic nanoparticles:synthesis,stabilization,functionalization,characterization,and applications[J].J Iran Chem Soc,2010,7(1):1-37.
13. ZHOU J,MENG L,LU Q,et al.Superparamagnetic submicro-megranates:Fe₃O₄ nanoparticles coated with highly cross-linked organic/inorganic hybrids[J].Chem Commun (Camb),2009,42:6370-6372.
14. LIANG Y Y,ZHANG L M,JIANG W,et al.Embedding magnetic nanoparticles into polysaccharide-based hydrogels for magnetically assisted bioseparation[J].Chem Phys Chem,2007,8(16):2367-2372.
15. GUL H,LU W,XU P,et al.Magnetic carbon nanotube labelling for haematopoietic stem/progenitor cell tracking[J].Nanotechnology,2010,21(15):155101.
16. GUO L,CUI X Z,LI Y S,et al.Hollow mesoporous carbon spheres with magnetic cores and their performance as separable bilirubin adsorbents[J].Chem Asian J,2009,4(9):1480-1485.
17. KIM Y P,CHO K,LEE D,et al.Efficient enrichment and desalting of protein digests using magnetic mesocellular carbon foams in matrix-assisted laser desorption/ionization mass spectrometry[J].Rapid Commun Mass Spectrom,2007,21(21):3435-3442.
18. LATHAM A H,WILLIAMS M E.Controlling transport and chemical functionality of magnetic nanoparticles[J].Acc Chem Res,2008,41(3):411-420.
19. GAO J H,GU H W,XU B.Multifunctional magnetic nanoparticles:design,synthesis,and biomedical applications[J].Acc Chem Res,2009,42(8):1097-1107.
20. CHEN H M,DENG C H,ZHANG X M.Synthesis of Fe₃O₄@SiO₂@PMMA core-shell-shell magnetic microspheres for highly efficient enrichment of peptides and proteins for MALDI-ToF MS analysis[J].Angew Chem Int Ed Engl,2010,49(3):607-611.
21. CORCHERO J L,VILLAVERDE A.Biomedical applications of distally controlled magnetic nanoparticles[J].Trends Biotechnol,2009,27(8):468-476.
22. GUO N,WU D C PAN X H,et al.Magnetic polymer microspheres with azidocarbonyl groups:synthesis,characterization and application in protein immobilization[J].J Appl Polym Sci,2009,112(4):2383-2390.
23. PENG Z G,HIDAJAT K,UDDIN M S.Conformational change of adsorbed and desorbed bovine serum albumin on nano-sized magnetic particles[J].Colloid Surf B-Biointerfaces,2004,33(1):15-21.
24. LIN J S,LIN Y S,KUO S T,et al.Purification of α-amylase from human saliva by superparamagnetic particles[J].J Sci Food Agric,2009,89(4):574-578.
25. LIN J S,LIN Y S,KUO S T,et al.Purification of soybean amylase by superparamagnetic particles[J].Food Chem,2009,117(1):94-98.
26. SOPACI S B,SIMŞEK I,TURAL B,et al.Carboligation reactions with benzaldehyde lyase immobilized on superparamagnetic solid support[J].Org Biomol Chem,2009,7(8):1658-1664.
27. DENG Y H,DENG C H,QI D W,et al.Synthesis of core/shell colloidal magnetic zeolite microspheres for the immobilization of trypsin[J].Adv Mater,2009,21(13):1377-1382.
28. JIN H,LIN J M,WANG X,et al.Magnetic particle-based chemiluminescence enzyme immunoassay for free thyroxine in human serum[J].J Pharm Biomed Anal,2009,50(5):891-896.
29. LIN H Y,CHEN W Y,CHEN Y C.Iron oxide/tantalum oxide core-shell magnetic nanoparticle-based microwave-assisted extraction for phosphopeptide enrichment from complex samples for MALDI MS analysis[J].Anal Bioanal Chem,2009,394(8):2129-2136.
30. KRÍZOVÁ J,SPANOVÁ A,RITTICH B,et al.Magnetic hydrophilic methacrylate-based polymer microspheres for genomic DNA isolation[J].J Chromatogr A,2005,1064(2):247-253.
31. ELAISSARI A.Magnetic latex particles in nanobiotechnologies for biomedical diagnostic applications:state of the art[J].Macromol Symp,2009,281(1):14-19.
32. ARKHIS A,ELAISSARI A,DELAIR T,et al.Capture of enveloped viruses using polymer tentacles containing magnetic latex particles[J].J Biomed Nanotechnol,2010,6(1):28-36.
33. GAO J H,XU B.Applications of nanomaterials inside cells[J].Nanotoday,2009,4(1):37-51.
34. XU Y,KARMAKAR A,WANG D Y,et al.Multifunctional Fe₃O₄ cored magnetic-quantum dot fluorescent nanocomposites for RF nanohyperthermia of cancer cells[J].J Phys Chem C,2010,114(11):5020-5026.
35. WU C L,HE H,GAO H J,et al.Synthesis of Fe₃O₄@SiO2@polymer nanoparticles for controlled drug release[J].Sci China Chem,2010,53(3):514-518.
36. XU R,SUN G Y,LI Q Y,et al.A dual-responsive superparamagnetic Fe₃O₄/Silica/PAH/PSS materia used for controlled release of chemmotherapeutic agent,keggin polyoxotungstate,PM-19[J].Solid State Sciences,2010,12(10):1720-1725.
37. YANG F,LI Y,CHEN Z,et al.Superparamagnetic iron oxide nanoparticle-embedded encapsulated microbubbles as dual contrast agents of magnetic resonance and ultrasound imaging[J].Biomaterials,2009,30(23-24):3882-3890.
38. TAN H,XUE J M,SHUTER B,et al.Synthesis of PEOlated Fe₃O₄@SiO₂ nanoparticles via bioinspired silification for magnetic resonance imaging[J].Adv Funct Mater,2010,20(5):722-731.
39. YANG F,JIN C,YANG D,et al.Magnetic functionalised carbon nanotubes as drug vehicles for cancer lymph node metastasis treatment[J].Eur J Cancer,2011,47(12):1873-1882.

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