Molecular Regulation of Skeletal Satellite Cell's Self-renewal_Journal of Biomedical Engineering

Authors：

XIONGHui ^1,2 , PUYabin ¹ , MAYuehui ¹ , HUQingyun ² ,  GUANWeijun ¹ , LIXiangchen ¹

1. Institute of Animal Science, Chinese Academy of Agricultural Science, Beijing 100194, China;
2. College of Basic Medicine, Jiamusi University, Jiamusi 154007, China;

Corresponding author：

GUANWeijun, Email: weijunguan301@gmail.com

Keywords：

skeletal satellite cell; self-renewal; molecular regulation

DOI：

10.7507/1001-5515.20140221

Video：

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Skeletal muscle possesses a remarkable ability for its regeneration and injured tissue repair. This ability depends on the activity and contributions of muscle satellite cells. Proliferating satellite cells, termed myogenic precursor cells or myoblasts, are activated and driven out of their quiescent state upon muscle injury. In this summary, we present a review to summarize the molecular regulation in skeletal satellite cells to light on the satellite cells' self-renewal mechanism.

Citation： XIONGHui, PUYabin, MAYuehui, HUQingyun, GUANWeijun, LIXiangchen. Molecular Regulation of Skeletal Satellite Cell's Self-renewal. Journal of Biomedical Engineering, 2014, 31(5): 1168-1171. doi: 10.7507/1001-5515.20140221 Copy

1.	XU Y, ZHOU Y, WANG N, et al. Integrating haplotypes and single genetic variability effects of the Pax7 gene on growth traits in two cattle breeds[J]. Genome, 2013, 56(1): 9-15.
2.	BORENSZTEIN M, MONNIER P, COURT F, et al. Myod and H19-Igf2 locus interactions are required for diaphragm formation in the mouse[J]. Development, 2013, 140(6): 1231-1239.
3.	ZAMMIT P S, GOLDING J P, NAGATA Y, et al. Muscle satellite cells adopt divergent fates: a mechanism for self-renewal?[J]. J Cell Biol, 2004, 166(3): 347-357.
4.	SACCO A, DOYONNAS R, KRAFT P, et al. Self-renewal and expansion of single transplanted muscle stem cells[J]. Nature, 2008, 456(7221): 502-506.
5.	BOLDRIN L, MUNTONI F, MORGAN J E. Are human and mouse satellite cells really the same?[J]. J Histochem Cytochem, 2010, 58(11): 941-955.
6.	DAY K, SHEFER G, SHEARER A, et al. The depletion of skeletal muscle satellite cells with age is concomitant with reduced capacity of single progenitors to produce reserve progeny[J]. Dev Biol, 2010, 340(2): 330-343.
7.	KUANG S, CHARGÉ S B, SEALE P, et al. Distinct roles for Pax7 and Pax3 in adult regenerative myogenesis[J]. J Cell Biol, 2006, 172(1): 103-113.
8.	KUANG S, KURODA K, LE GRAND F, et al. Asymmetric self-renewal and commitment of satellite stem cells in muscle[J]. Cell, 2007, 129(5): 999-1010.
9.	TEDESCO F S, DELLAVALLE A, DIAZ-MANERA J, et al. Repairing skeletal muscle: regenerative potential of skeletal muscle stem cells[J]. J Clin Invest, 2010, 120(1): 11-19.
10.	CBIRESSI S, RANDO T A. Heterogeneity in the muscle satellite cell population[J]. Semin Cell Dev Biol, 2010, 21(8): 845-854.
11.	JOE A W, YI L, NATARAJAN A, et al. Muscle injury activates resident fibro/adipogenic progenitors that facilitate myogenesis[J]. Nat Cell Biol, 2010, 12(2): 153-163.
12.	ONO Y, BOLDRIN L, KNOPP P, et al. Muscle satellite cells are a functionally heterogeneous population in both somite-derived and branchiomeric muscles[J]. Dev Biol, 2010, 337(1): 29-41.
13.	ONO Y, MASUDA S, NAM H S, et al. Slow-dividing satellite cells retain long-term self-renewal ability in adult muscle[J]. J Cell Sci, 2012, 125(Pt 5): 1309-1317.
14.	ASAKURA A, HIRAI H, KABLAR B, et al. Increased survival of muscle stem cells lacking the MyoD gene after transplantation into regenerating skeletal muscle[J]. Proc Natl Acad Sci U S A, 2007, 104(42): 16552-16557.
15.	SHAVLAKADZE T, MCGEACHIE J, GROUNDS M D. Delayed but excellent myogenic stem cell response of regenerating geriatric skeletal muscles in mice[J]. Biogerontology, 2010, 11(3): 363-376.
16.	HIRAI H, VERMA M, WATANABE S, et al. MyoD regulates apoptosis of myoblasts through microRNA-mediated down-regulation of Pax3[J]. J Cell Biol, 2010, 191(2): 347-365.
17.	LINDSTRÖM M, PEDROSA-DOMELLÖF F, THORNELL L E. Satellite cell heterogeneity with respect to expression of MyoD, myogenin, Dlk1 and c-Met in human skeletal muscle: application to a cohort of power lifters and sedentary men[J]. Histochem Cell Biol, 2010, 134(4): 371-385.
18.	LE GRAND F, GRIFONE R, MOURIKIS P, et al. Six1 regulates stem cell repair potential and self-renewal during skeletal muscle regeneration[J]. J Cell Biol, 2012, 198(5): 815-832.
19.	GILBERT P M, HAVENSTRITE K L, MAGNUSSON K E, et al. Substrate elasticity regulates skeletal muscle stem cell self-renewal in culture[J]. Science, 2010, 329(5995): 1078-1081.
20.	WHITE R B, BIÉRINX A S, GNOCCHI V F, et al. Dynamics of muscle fibre growth during postnatal mouse development[J]. BMC Dev Biol, 2010, 10: 21.
21.	TROY A, CADWALLADER A B, FEDOROV Y, et al. Coordination of satellite cell activation and self-renewal by Par-complex-dependent asymmetric activation of p38α/β MAPK[J]. Cell Stem Cell, 2012, 11(4): 541-553.
22.	CHEUNG T H, QUACH N L, CHARVILLE G W, et al. Maintenance of muscle stem-cell quiescence by microRNA-489[J]. Nature, 2012, 482(7386): 524-528.
23.	LAI E C. Notch signaling: control of cell communication and cell fate[J]. Development, 2004, 131(5): 965-973.
24.	MOURIKIS P, SAMBASIVAN R, CASTEL D, et al. A critical requirement for notch signaling in maintenance of the quiescent skeletal muscle stem cell state[J]. Stem Cells, 2012, 30(2): 243-252.
25.	BJORNSON C R, CHEUNG T H, LIU L, et al. Notch signaling is necessary to maintain quiescence in adult muscle stem cells[J]. Stem Cells, 2012, 30(2): 232-242.
26.	FUKADA S, YAMAGUCHI M, KOKUBO H, et al. Hesr1 and Hesr3 are essential to generate undifferentiated quiescent satellite cells and to maintain satellite cell numbers[J]. Development, 2011, 138(21): 4609-4619.
27.	BRÖHL D, VASYUTINA E, CZAJKOWSKI M T, et al. Colonization of the satellite cell niche by skeletal muscle progenitor cells depends on notch signals[J]. Dev Cell, 2012, 23(3): 469-481.
28.	LIU W, WEN Y, BI P, et al. Hypoxia promotes satellite cell self-renewal and enhances the efficiency of myoblast transplantation[J]. Development, 2012, 139(16): 2857-2865.
29.	MAJMUNDAR A J, SKULI N, MESQUITA R C, et al. O₂ regulates skeletal muscle progenitor differentiation through phosphatidylinositol 3-kinase/AKT signaling[J]. Mol Cell Biol, 2012, 32(1): 36-49.
30.	ROCHETEAU P, GAYRAUD-MOREL B, SIEGL-CACHEDENIER I, et al. A subpopulation of adult skeletal muscle stem cells retains all template DNA strands after cell division[J]. Cell, 2012, 148(1-2): 112-125.
31.	KAWABE Y, WANG Y X, MCKINNELL I W, et al. Carm1 regulates Pax7 transcriptional activity through MLL1/2 recruitment during asymmetric satellite stem cell divisions[J]. Cell Stem Cell, 2012, 11(3): 333-345.

1. XU Y, ZHOU Y, WANG N, et al. Integrating haplotypes and single genetic variability effects of the Pax7 gene on growth traits in two cattle breeds[J]. Genome, 2013, 56(1): 9-15.
2. BORENSZTEIN M, MONNIER P, COURT F, et al. Myod and H19-Igf2 locus interactions are required for diaphragm formation in the mouse[J]. Development, 2013, 140(6): 1231-1239.
3. ZAMMIT P S, GOLDING J P, NAGATA Y, et al. Muscle satellite cells adopt divergent fates: a mechanism for self-renewal?[J]. J Cell Biol, 2004, 166(3): 347-357.
4. SACCO A, DOYONNAS R, KRAFT P, et al. Self-renewal and expansion of single transplanted muscle stem cells[J]. Nature, 2008, 456(7221): 502-506.
5. BOLDRIN L, MUNTONI F, MORGAN J E. Are human and mouse satellite cells really the same?[J]. J Histochem Cytochem, 2010, 58(11): 941-955.
6. DAY K, SHEFER G, SHEARER A, et al. The depletion of skeletal muscle satellite cells with age is concomitant with reduced capacity of single progenitors to produce reserve progeny[J]. Dev Biol, 2010, 340(2): 330-343.
7. KUANG S, CHARGÉ S B, SEALE P, et al. Distinct roles for Pax7 and Pax3 in adult regenerative myogenesis[J]. J Cell Biol, 2006, 172(1): 103-113.
8. KUANG S, KURODA K, LE GRAND F, et al. Asymmetric self-renewal and commitment of satellite stem cells in muscle[J]. Cell, 2007, 129(5): 999-1010.
9. TEDESCO F S, DELLAVALLE A, DIAZ-MANERA J, et al. Repairing skeletal muscle: regenerative potential of skeletal muscle stem cells[J]. J Clin Invest, 2010, 120(1): 11-19.
10. CBIRESSI S, RANDO T A. Heterogeneity in the muscle satellite cell population[J]. Semin Cell Dev Biol, 2010, 21(8): 845-854.
11. JOE A W, YI L, NATARAJAN A, et al. Muscle injury activates resident fibro/adipogenic progenitors that facilitate myogenesis[J]. Nat Cell Biol, 2010, 12(2): 153-163.
12. ONO Y, BOLDRIN L, KNOPP P, et al. Muscle satellite cells are a functionally heterogeneous population in both somite-derived and branchiomeric muscles[J]. Dev Biol, 2010, 337(1): 29-41.
13. ONO Y, MASUDA S, NAM H S, et al. Slow-dividing satellite cells retain long-term self-renewal ability in adult muscle[J]. J Cell Sci, 2012, 125(Pt 5): 1309-1317.
14. ASAKURA A, HIRAI H, KABLAR B, et al. Increased survival of muscle stem cells lacking the MyoD gene after transplantation into regenerating skeletal muscle[J]. Proc Natl Acad Sci U S A, 2007, 104(42): 16552-16557.
15. SHAVLAKADZE T, MCGEACHIE J, GROUNDS M D. Delayed but excellent myogenic stem cell response of regenerating geriatric skeletal muscles in mice[J]. Biogerontology, 2010, 11(3): 363-376.
16. HIRAI H, VERMA M, WATANABE S, et al. MyoD regulates apoptosis of myoblasts through microRNA-mediated down-regulation of Pax3[J]. J Cell Biol, 2010, 191(2): 347-365.
17. LINDSTRÖM M, PEDROSA-DOMELLÖF F, THORNELL L E. Satellite cell heterogeneity with respect to expression of MyoD, myogenin, Dlk1 and c-Met in human skeletal muscle: application to a cohort of power lifters and sedentary men[J]. Histochem Cell Biol, 2010, 134(4): 371-385.
18. LE GRAND F, GRIFONE R, MOURIKIS P, et al. Six1 regulates stem cell repair potential and self-renewal during skeletal muscle regeneration[J]. J Cell Biol, 2012, 198(5): 815-832.
19. GILBERT P M, HAVENSTRITE K L, MAGNUSSON K E, et al. Substrate elasticity regulates skeletal muscle stem cell self-renewal in culture[J]. Science, 2010, 329(5995): 1078-1081.
20. WHITE R B, BIÉRINX A S, GNOCCHI V F, et al. Dynamics of muscle fibre growth during postnatal mouse development[J]. BMC Dev Biol, 2010, 10: 21.
21. TROY A, CADWALLADER A B, FEDOROV Y, et al. Coordination of satellite cell activation and self-renewal by Par-complex-dependent asymmetric activation of p38α/β MAPK[J]. Cell Stem Cell, 2012, 11(4): 541-553.
22. CHEUNG T H, QUACH N L, CHARVILLE G W, et al. Maintenance of muscle stem-cell quiescence by microRNA-489[J]. Nature, 2012, 482(7386): 524-528.
23. LAI E C. Notch signaling: control of cell communication and cell fate[J]. Development, 2004, 131(5): 965-973.
24. MOURIKIS P, SAMBASIVAN R, CASTEL D, et al. A critical requirement for notch signaling in maintenance of the quiescent skeletal muscle stem cell state[J]. Stem Cells, 2012, 30(2): 243-252.
25. BJORNSON C R, CHEUNG T H, LIU L, et al. Notch signaling is necessary to maintain quiescence in adult muscle stem cells[J]. Stem Cells, 2012, 30(2): 232-242.
26. FUKADA S, YAMAGUCHI M, KOKUBO H, et al. Hesr1 and Hesr3 are essential to generate undifferentiated quiescent satellite cells and to maintain satellite cell numbers[J]. Development, 2011, 138(21): 4609-4619.
27. BRÖHL D, VASYUTINA E, CZAJKOWSKI M T, et al. Colonization of the satellite cell niche by skeletal muscle progenitor cells depends on notch signals[J]. Dev Cell, 2012, 23(3): 469-481.
28. LIU W, WEN Y, BI P, et al. Hypoxia promotes satellite cell self-renewal and enhances the efficiency of myoblast transplantation[J]. Development, 2012, 139(16): 2857-2865.
29. MAJMUNDAR A J, SKULI N, MESQUITA R C, et al. O₂ regulates skeletal muscle progenitor differentiation through phosphatidylinositol 3-kinase/AKT signaling[J]. Mol Cell Biol, 2012, 32(1): 36-49.
30. ROCHETEAU P, GAYRAUD-MOREL B, SIEGL-CACHEDENIER I, et al. A subpopulation of adult skeletal muscle stem cells retains all template DNA strands after cell division[J]. Cell, 2012, 148(1-2): 112-125.
31. KAWABE Y, WANG Y X, MCKINNELL I W, et al. Carm1 regulates Pax7 transcriptional activity through MLL1/2 recruitment during asymmetric satellite stem cell divisions[J]. Cell Stem Cell, 2012, 11(3): 333-345.

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Molecular Regulation of Skeletal Satellite Cell's Self-renewal

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