Studying effects of 50 Hz sinusoidal electromagnetic fields (SEMFs) with different intensities on peak bone mass (PBM) of rats may provide a theoretical basis for application of electromagnetic clinical field. 30 female SD rats, 6 weeks of age, were randomly divided into three groups: the control group, 0.1 mT electromagnetic field group (EMFs) and 0.6 mT EMFs. The EMFs groups were treated for 3 h/day. After 8 weeks, we examined their bone mineral densities (BMD), measured their bone biomechanical properties, and made serum levels of osteocalcin (OC), tartrate-resistant acid phosphatase 5b (TRACP 5b), and histomorphometry. It was found that the BMD (P < 0.01), maximum mechanical load (P < 0.01) in the 0.1 mT group were significantly higher than those in the control group, and Yield strength (P < 0.05), the analyses of serum bone turnover markers and histomorphometric parameters were better than those in the control group (P < 0.05). However, the 0.6 mT group did not have significantly difference comparing with that in the control group. This study proved that 50 Hz 0.1 mT SEMFs can increased BMD, bone strength, and bone tissue microstructure. Therefore, 50 Hz 0.1 mT SEMFs can improve peak bone mass of rats.
Citation：
GAOYuhai, CHENGKui, GEBaofeng, ZHENPing, ZHOUJian, MAXiaoni, LIShaofeng, CHENKeming. Effects of 50 Hz Sinusoidal Electromagnetic Field with Different Intensities on Rat Peak Bone Mass. Journal of Biomedical Engineering, 2016, 32(1): 116-119. doi: 10.7507/1001-5515.20150021
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Copyright © the editorial department of Journal of Biomedical Engineering of West China Medical Publisher. All rights reserved
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- 1. LANE N E. Epidemiology, etiology, and diagnosis of osteoporosis[J]. American Journal of Obstetrics and Gynecology, 2006, 194(Suppl 2): S3-S11.
- 2. RACHNER T D, KHOSLA S, HOFBAUER L C. New horizons in osteoporosis [J]. Lancet, 2011, 377(9773): 1276-1287.
- 3. 安珍, 程静, 王文志, 等.峰值骨量与骨质疏松症[J].现代康复, 2001, 4:003.
- 4. MARDON J, MATHEY J, KATI-COULIBALY S, et al. Influence of lifelong soy isoflavones consumption on bone mass in the rat[J]. Experimental Biology and Medicine, 2008, 233(2): 229-237.
- 5. GAUTAM A K, BHARGAVAN B, TYAGI A M, et al. Differential effects of formononetin and cladrin on osteoblast function, peak bone mass achievement and bioavailability in rats[J]. The Journal of Nutritional Biochemistry, 2011, 22(4): 318-327.
- 6. PURICELLI E, DUTRA N B, PONZONI D. Histological evaluation of the influence of magnetic field application in autogenous bone grafts in rats[J]. Head Face Med, 2009, 5(1):1-6.
- 7. LIPIECA E, KOWALSKAA J, WIECHE AĆU A A, et al. Infrared spectroscopy in molecular study of the piezoelectric effect in pig's shin bone[J]. Acta Physica Polonica A, 2012, 121(2): 539-542.
- 8. 贾雪, 何成奇.脉冲电磁场治疗绝经后骨质疏松症的研究进展[J].华西医学, 2009, 24(1): 247-249.
- 9. 刘纪涛, 陶军.脉冲电磁场影响骨折愈合的研究进展[J].中国组织工程研究与临床康复, 2010, 14(4):689-692.
- 10. 周建, 李雪雁, 陈克明, 等.50 Hz正弦交变磁场对体外培养大鼠成骨细胞分化及BMP-2和collagen-Ⅰ基因表达的影响[J].中国医学物理学杂志, 2010, 27(5): 2173-2177.
- 11. PARK J A, HA S K, KANG T H, et al. Protective effect of apigenin on ovariectomy-induced bone loss in rats [J]. Life sciences, 2008, 82(25): 1217-1223.
- 12. TEO J, SI-HOE K M, KEH J E, et al. Relationship between CT intensity, micro-architecture and mechanical properties of porcine vertebral cancellous bone[J]. Clinical Biomechanics, 2006, 21(3): 235-244.
