Advances in Molecular Mechanisms of Tenascin-C in Promoting Tumor Metastasis_Journal of Biomedical Engineering

Authors：

NONGYunhong ^1,2 ,  BAILang ^1,2 , TANGHong ^1,2

1. Center of Infectious Diseases, West China Hospital, Sichuan University, Chengdu 610041, China;
2. Division of Infectious Diseases, State Key Laboratory of Biotherapy, Sichuan University, Chengdu 610041, China;

Corresponding author：

BAILang, Email: pangbailang@163.com

Keywords：

tenascin-C; tumor metastasis; tumor cell adhesion; tumor invasion; tumor angiogenesis; signal pathway

DOI：

10.7507/1001-5515.20150044

Video：

Export PDF Favorites Scan Get Citation

Abstract Full text Figures/Tables Video References Cited by

Tenascin-C (TNC) is an extracellular matrix glycoprotein, which is usually highly expressed in embryonic tissues and tumor tissues, but is not expressed or just lowly expressed in mature tissues. TNC is involved in various complex signaling pathways during tumor metastasis, especially through modulating FAK, RhoA, Wnt and Notch pathways by interacting with syndecan-4, integrinα5β1, matrix metalloproteinases (MMPs) and vascular endothelial growth factor (VEGF). As a result, TNC affects epithelial mesenchymal transition, tumor cell adhesion, proliferation and angiogenesis, which eventually enhances the invasion and metastasis ability of many tumors. Further studies have demonstrated that TNC could be used as prognosis or metastasis marker of patients with malignant tumor.

Citation： NONGYunhong, BAILang, TANGHong. Advances in Molecular Mechanisms of Tenascin-C in Promoting Tumor Metastasis. Journal of Biomedical Engineering, 2015, 32(1): 240-244. doi: 10.7507/1001-5515.20150044 Copy

1.	MIDWOOD K S, HUSSENET T, LANGLOIS B, et al. Advances in tenascin-C biology[J]. Cell Mol Life Sci, 2011, 68(19):3175-3199.
2.	CHIQUET-EHRISMANN R, TUCKER R P. Tenascins and the importance of adhesion modulation[J]. Cold Spring Harb Perspect Biol, 2011, 3(5): pii: a004960.
3.	MIDWOOD K S, OREND G. The role of tenascin-C in tissue injury and tumorigenesis[J]. J Cell Commun Signal, 2009, 3(3-4): 287-310.
4.	NAGAHARU K, ZHANG Xinhui, YOSHIDA T, et al. Tenascin C induces epithelial-mesenchymal transition-like change accompanied by SRC activation and focal adhesion kinase phosphorylation in human breast cancer cells[J]. Am J Pathol, 2011, 178(2): 754-763.
5.	CHONG H C, TAN C K, HUANG R L, et al. Matricellular proteins: a sticky affair with cancers[J]. J Oncol, 2012, 2012: Article ID 351089.
6.	QUIRICO-SANTOS T, FONSECA C O, LAGROTA-CANDIDO J. Brain sweet brain: importance of sugars for the cerebral microenvironment and tumor development[J]. Arq Neuropsiquiatr, 2010, 68(5): 799-803.
7.	ALLEN M D, VAZIRI R, GREEN M, et al. Clinical and functional significance ofα9β1 integrin expression in breast cancer: a novel cell-surface marker of the basal phenotype that promotes tumour cell invasion[J]. J Pathol, 2011, 223(5): 646-658.
8.	PAL'TSEVA E M, SAMOFALOVA O, GORBACHEVA IuV, et al. Molecular markers of colorectal adrenocarcinoma progression[J]. Arkh Patol, 2012, 74(2): 14-18.
9.	SAITO Y, IMAZEKI H, MIURA S, et al. A peptide derived from tenascin-C induces beta1 integrin activation through syndecan-4[J]. J Biol Chem, 2007, 282(48): 34929-34937.
10.	PARON I, BERCHTOLD S, VÖRÖS J, et al. Tenascin-C enhances pancreatic cancer cell growth and motility and affects cell adhesion through activation of the integrin pathway[J]. PLoS One, 2011, 6(6): e21684.
11.	XU Jielin, MAURER L M, HOFFMANN B R, et al. iso-DGR sequences do not mediate binding of fibronectin N-terminal modules to adherent fibronectin-null fibroblasts[J]. J Biol Chem, 2010, 285(12): 8563-8571.
12.	VARGA I, HUTÓCZKI G, SZEMCSÁK C D, et al. Brevican, neurocan, tenascin-C and versican are mainly responsible for the invasiveness of low-grade astrocytoma[J]. Pathol Oncol Res, 2012, 18(2): 413-420.
13.	SARKAR S, YONG V W. Reduction of protein kinase C delta attenuates tenascin-C stimulated glioma invasion in three-dimensional matrix[J]. Carcinogenesis, 2010, 31(2): 311-317.
14.	GUTTERY D S, HANCOX R A, MULLIGAN K T, et al. Association of invasion-promoting tenascin-C additional domains with breast cancers in young women[J]. Breast Cancer Res, 2010, 12(4): R57.
15.	GRAHOVAC J, BECKER D, WELLS A. Melanoma cell invasiveness is promoted at least in part by the epidermal growth factor-like repeats of tenascin-C[J]. J Invest Dermatol, 2013, 133(1): 210-220.
16.	尹传昌, 廖晓峰, 陈雯, 等.Tenascin-C在人原发性肝细胞癌浸润、转移和血管生成中的作用[J].华中科技大学学报:医学版, 2012, 41(3): 278-283.
17.	HAU P, KUNZ-SCHUGHART L A, R?MMELE P, et al. Tenascin-C protein is induced by transforming growth factor-beta1 but does not correlate with time to tumor progression in high-grade gliomas[J]. J Neurooncol, 2006, 77(1): 1-7.
18.	REINERTSEN T, HALGUNSET J, VISET T, et al. Gene expressional changes in prostate fibroblasts from cancerous tissue[J]. APMIS, 2012, 120(7): 558-571.
19.	KIM M Y, KIM O R, CHOI Y S, et al. Selection and characterization of tenascin C targeting peptide[J]. Mol Cells, 2012, 33(1): 71-77.
20.	ROLLE K, NOWAK S, WYSZKO E, et al. Promising human brain tumors therapy with interference RNA intervention (iRNAi)[J]. Cancer Biol Ther, 2010, 9(5): 396-406.
21.	O'CONNELL J T, SUGIMOTO H, COOKE V G, et al. VEGF-A and Tenascin-C produced by S100A4+ stromal cells are important for metastatic colonization[J]. Proc Natl Acad Sci U S A, 2011, 108(38): 16002-16007.
22.	BRELLIER F, CHIQUET-EHRISMANN R. How do tenascins influence the birth and life of a malignant cell?[J]. J Cell Mol Med, 2012, 16(1): 32-40.
23.	VAN OBBERGHEN-SCHILLING E, TUCKER R P, SAUPE F, et al. Fibronectin and tenascin-C: accomplices in vascular morphogenesis during development and tumor growth[J]. Int J Dev Biol, 2011, 55(4/5): 511-525.
24.	PEZZOLO A, PARODI F, MARIMPIETRI D, et al. Oct-4+/Tenascin C+ neuroblastoma cells serve as progenitors of tumor-derived endothelial cells[J]. Cell Res, 2011, 21(10): 1470-1486.
25.	HUANG Wentao, CHIQUET-EHRISMANN R, MOYANO J V, et al. Interference of tenascin-C with syndecan-4 binding to fibronectin blocks cell adhesion and stimulates tumor cell proliferation[J]. Cancer Res, 2001, 61(23): 8586-8594.
26.	RUIZ C, HUANG Wentao, HEGI M E, et al. Growth promoting signaling by tenascin-C [corrected][J]. Cancer Res, 2004, 64(20): 7377-7385.
27.	LANGE K, KAMMERER M, SAUPE F, et al. Combined lysophosphatidic acid/platelet-derived growth factor signaling triggers glioma cell migration in a tenascin-C microenvironment[J]. Cancer Res, 2008, 68(17): 6942-6952.
28.	OSKARSSON T, ACHARYYA S, ZHANG X H, et al. Breast cancer cells produce tenascin C as a metastatic niche component to colonize the lungs[J]. Nat Med, 2011, 17(7): 867-874.
29.	BEITER K, HIENDLMEYER E, BRABLETZ T, et al. beta-Catenin regulates the expression of tenascin-C in human colorectal tumors[J]. Oncogene, 2005, 24(55): 8200-8204.
30.	SIVASANKARAN B, DEGEN M, GHAFFARI A, et al. Tenascin-C is a novel RBPJκ-induced target gene for Notch signaling in gliomas[J]. Cancer Res, 2009, 69(2): 458-465.
31.	OHYAMA T, NAGATA Takashi, TSUDA K, et al. Structure of Musashi1 in a complex with target RNA: the role of aromatic stacking interactions[J]. Nucleic Acids Res, 2012, 40(7): 3218-3231.

1. MIDWOOD K S, HUSSENET T, LANGLOIS B, et al. Advances in tenascin-C biology[J]. Cell Mol Life Sci, 2011, 68(19):3175-3199.
2. CHIQUET-EHRISMANN R, TUCKER R P. Tenascins and the importance of adhesion modulation[J]. Cold Spring Harb Perspect Biol, 2011, 3(5): pii: a004960.
3. MIDWOOD K S, OREND G. The role of tenascin-C in tissue injury and tumorigenesis[J]. J Cell Commun Signal, 2009, 3(3-4): 287-310.
4. NAGAHARU K, ZHANG Xinhui, YOSHIDA T, et al. Tenascin C induces epithelial-mesenchymal transition-like change accompanied by SRC activation and focal adhesion kinase phosphorylation in human breast cancer cells[J]. Am J Pathol, 2011, 178(2): 754-763.
5. CHONG H C, TAN C K, HUANG R L, et al. Matricellular proteins: a sticky affair with cancers[J]. J Oncol, 2012, 2012: Article ID 351089.
6. QUIRICO-SANTOS T, FONSECA C O, LAGROTA-CANDIDO J. Brain sweet brain: importance of sugars for the cerebral microenvironment and tumor development[J]. Arq Neuropsiquiatr, 2010, 68(5): 799-803.
7. ALLEN M D, VAZIRI R, GREEN M, et al. Clinical and functional significance ofα9β1 integrin expression in breast cancer: a novel cell-surface marker of the basal phenotype that promotes tumour cell invasion[J]. J Pathol, 2011, 223(5): 646-658.
8. PAL'TSEVA E M, SAMOFALOVA O, GORBACHEVA IuV, et al. Molecular markers of colorectal adrenocarcinoma progression[J]. Arkh Patol, 2012, 74(2): 14-18.
9. SAITO Y, IMAZEKI H, MIURA S, et al. A peptide derived from tenascin-C induces beta1 integrin activation through syndecan-4[J]. J Biol Chem, 2007, 282(48): 34929-34937.
10. PARON I, BERCHTOLD S, VÖRÖS J, et al. Tenascin-C enhances pancreatic cancer cell growth and motility and affects cell adhesion through activation of the integrin pathway[J]. PLoS One, 2011, 6(6): e21684.
11. XU Jielin, MAURER L M, HOFFMANN B R, et al. iso-DGR sequences do not mediate binding of fibronectin N-terminal modules to adherent fibronectin-null fibroblasts[J]. J Biol Chem, 2010, 285(12): 8563-8571.
12. VARGA I, HUTÓCZKI G, SZEMCSÁK C D, et al. Brevican, neurocan, tenascin-C and versican are mainly responsible for the invasiveness of low-grade astrocytoma[J]. Pathol Oncol Res, 2012, 18(2): 413-420.
13. SARKAR S, YONG V W. Reduction of protein kinase C delta attenuates tenascin-C stimulated glioma invasion in three-dimensional matrix[J]. Carcinogenesis, 2010, 31(2): 311-317.
14. GUTTERY D S, HANCOX R A, MULLIGAN K T, et al. Association of invasion-promoting tenascin-C additional domains with breast cancers in young women[J]. Breast Cancer Res, 2010, 12(4): R57.
15. GRAHOVAC J, BECKER D, WELLS A. Melanoma cell invasiveness is promoted at least in part by the epidermal growth factor-like repeats of tenascin-C[J]. J Invest Dermatol, 2013, 133(1): 210-220.
16. 尹传昌, 廖晓峰, 陈雯, 等.Tenascin-C在人原发性肝细胞癌浸润、转移和血管生成中的作用[J].华中科技大学学报:医学版, 2012, 41(3): 278-283.
17. HAU P, KUNZ-SCHUGHART L A, R?MMELE P, et al. Tenascin-C protein is induced by transforming growth factor-beta1 but does not correlate with time to tumor progression in high-grade gliomas[J]. J Neurooncol, 2006, 77(1): 1-7.
18. REINERTSEN T, HALGUNSET J, VISET T, et al. Gene expressional changes in prostate fibroblasts from cancerous tissue[J]. APMIS, 2012, 120(7): 558-571.
19. KIM M Y, KIM O R, CHOI Y S, et al. Selection and characterization of tenascin C targeting peptide[J]. Mol Cells, 2012, 33(1): 71-77.
20. ROLLE K, NOWAK S, WYSZKO E, et al. Promising human brain tumors therapy with interference RNA intervention (iRNAi)[J]. Cancer Biol Ther, 2010, 9(5): 396-406.
21. O'CONNELL J T, SUGIMOTO H, COOKE V G, et al. VEGF-A and Tenascin-C produced by S100A4+ stromal cells are important for metastatic colonization[J]. Proc Natl Acad Sci U S A, 2011, 108(38): 16002-16007.
22. BRELLIER F, CHIQUET-EHRISMANN R. How do tenascins influence the birth and life of a malignant cell?[J]. J Cell Mol Med, 2012, 16(1): 32-40.
23. VAN OBBERGHEN-SCHILLING E, TUCKER R P, SAUPE F, et al. Fibronectin and tenascin-C: accomplices in vascular morphogenesis during development and tumor growth[J]. Int J Dev Biol, 2011, 55(4/5): 511-525.
24. PEZZOLO A, PARODI F, MARIMPIETRI D, et al. Oct-4+/Tenascin C+ neuroblastoma cells serve as progenitors of tumor-derived endothelial cells[J]. Cell Res, 2011, 21(10): 1470-1486.
25. HUANG Wentao, CHIQUET-EHRISMANN R, MOYANO J V, et al. Interference of tenascin-C with syndecan-4 binding to fibronectin blocks cell adhesion and stimulates tumor cell proliferation[J]. Cancer Res, 2001, 61(23): 8586-8594.
26. RUIZ C, HUANG Wentao, HEGI M E, et al. Growth promoting signaling by tenascin-C [corrected][J]. Cancer Res, 2004, 64(20): 7377-7385.
27. LANGE K, KAMMERER M, SAUPE F, et al. Combined lysophosphatidic acid/platelet-derived growth factor signaling triggers glioma cell migration in a tenascin-C microenvironment[J]. Cancer Res, 2008, 68(17): 6942-6952.
28. OSKARSSON T, ACHARYYA S, ZHANG X H, et al. Breast cancer cells produce tenascin C as a metastatic niche component to colonize the lungs[J]. Nat Med, 2011, 17(7): 867-874.
29. BEITER K, HIENDLMEYER E, BRABLETZ T, et al. beta-Catenin regulates the expression of tenascin-C in human colorectal tumors[J]. Oncogene, 2005, 24(55): 8200-8204.
30. SIVASANKARAN B, DEGEN M, GHAFFARI A, et al. Tenascin-C is a novel RBPJκ-induced target gene for Notch signaling in gliomas[J]. Cancer Res, 2009, 69(2): 458-465.
31. OHYAMA T, NAGATA Takashi, TSUDA K, et al. Structure of Musashi1 in a complex with target RNA: the role of aromatic stacking interactions[J]. Nucleic Acids Res, 2012, 40(7): 3218-3231.

Journal of Biomedical Engineering

Advances in Molecular Mechanisms of Tenascin-C in Promoting Tumor Metastasis

Abstract Full text Figures/Tables Video References Cited by

Previous Article

Next Article

Format

Content